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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P21796 New Search
12PDB entries
13Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2JK4 Structure of the human voltage-dependent anion channel Deposited 2008-08-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–283（282 aa） Fragment：RESIDUES 2-283
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 0.2 M MAGNESIUM CHLORIDE HEXAHYDRATE, 0.1 M HEPES SODIUM PH 7.5, 30% V/V POLYETHYLENE GLYCOL 400
Resolution 4.10 Å R-free 0.387
2K4T Solution structure of human VDAC-1 in LDAO micelles Deposited 2008-06-17 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–283（283 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 25；Pressure AMBIENT
NMR sample composition 1 mM [U-13C; U-15N; U-2H] VDAC-1, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
5JDP E73V mutant of the human voltage-dependent anion channel Deposited 2016-04-17 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–283（282 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；310 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition 0.8 mM U- 2H, 15N_sample E73V mutant of the Voltage-dependent anion channel 1, 2 % [U-2H] LDAO, 20 mM [U-2H] TRIS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
5XDN Crystal structure of human voltage-dependent anion channel 1 (hVDAC1) in P22121 space group Deposited 2017-03-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–283（283 aa）
Chain B 1–283（283 aa）
Not recorded D12 DODECANE × 2 HEX HEXANE × 4 OCT N-OCTANE × 1 D10 DECANE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；36% PEG300, 0.1 M MES (pH 6.5), 0.1 M NaCl
Resolution 3.15 Å R-free 0.300
5XDO Crystal structure of human voltage-dependent anion channel 1 (hVDAC1) in C222 space group Deposited 2017-03-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–283（283 aa）
Chain B 1–283（283 aa）
Not recorded SPD SPERMIDINE × 2 OCT N-OCTANE × 4 LNK PENTANE × 2 HEX HEXANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；45% PEG300, 0.1 M HEPES (pH 7.0), 0.15 M NaCl, 11 mM spermidine
Resolution 3.10 Å R-free 0.298
6G6U The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 2.7 Angstrom resolution Deposited 2018-04-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–283（283 aa）
Chain B 1–283（283 aa）
Not recorded MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 3 NO3 NITRATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；25.5% precipitant mix 4 [25% (v/v) MPD, 25% (w/v) PEG 1000, 25% (w/v) PEG 3350], 0.06 M NH4NO3, 0.1 buffer system 1 [imidazole and MES adjusted to pH 6.5]
Resolution 2.74 Å R-free 0.287
6G73 The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 3.3 Angstrom resolution Deposited 2018-04-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–283（283 aa）
Chain D 1–283（283 aa）
Not recorded MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；292.2 K；25.5% Precipitant mix 4 [precipitant mix 4 consists of 25% (v/v) MPD, 25% (w/v) PEG1000, 25% (w/v) PEG3350], 0.06M NaNO3, 0.08M K2HPO4, 0.1M Buffer System2 [HEPES and MOPS adjusted to pH 7.5]
Resolution 3.27 Å R-free 0.298
6G73 The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 3.3 Angstrom resolution Deposited 2018-04-04 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–283（283 aa）
Chain B 1–283（283 aa）
Not recorded MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；292.2 K；25.5% Precipitant mix 4 [precipitant mix 4 consists of 25% (v/v) MPD, 25% (w/v) PEG1000, 25% (w/v) PEG3350], 0.06M NaNO3, 0.08M K2HPO4, 0.1M Buffer System2 [HEPES and MOPS adjusted to pH 7.5]
Resolution 3.27 Å R-free 0.298
6TIQ Refined solution NMR structure of hVDAC-1 in detergent micelles Deposited 2019-11-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–283（283 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；303.15 K；Ionic strength (raw mmCIF value) 225；Pressure 1
NMR sample composition 0.6 mM U-99%-2H,13C,15N hVDAC-1, 3 % no LDAO, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.6 mM [ U -99%- 2 H, 13 C, 15 N; 99%- 1 H delta -IL; 99%- 1 H gamma -V] hVDAC-1, 3 % [U-99% 2H] LDAO, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.6 mM [ U -99%- 2 H, 15 N; 99%- 1 H delta , 13 C delta -IL; 99%- 1 H gamma , 13 C gamma -V] hVDAC-1, 3 % [U-99% 2H] LDAO, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6TIR NOE based model of hVDAC-1 bound to beta-NADH in detergent micelles Deposited 2019-11-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–283（283 aa）
Not recorded NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 SOLUTION NMR
NMR measurement conditions pH 6.5；303.15 K；Ionic strength (raw mmCIF value) 25；Pressure 1
NMR sample composition 0.5 mM [U-99%-2H, 15N; 99%-1Hdelta-IL; 99%-1Hgamma-V] human VDAC-1, 45 mM beta-NADH, 150 mM [U-99% 2H] LDAO, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5 mM [U-99%-2H, 15N; 99%-1H,13C-delta-IL; 99%-1H,13Cgamma-V] human VDAC-1, 45 mM beta-NADH, 150 mM [U-99% 2H] LDAO, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5 mM U-99%-2H,15N,13C human VDAC-1, 150 mM [U-99% 2H] LDAO, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
7QI2 Magic-angle spinning NMR structure of the human voltage-dependent anion channel 1 (E73V/C127A/C232S) in DMPC lipid bilayers Deposited 2021-12-14 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–283（283 aa）
Mutation：E73V/C127A/C232S No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 6.5；285 K；Ionic strength (raw mmCIF value) 0.21；Pressure 1
NMR sample composition 66 % w/w [U-13C; U-15N; U-2H] u[2H,13C,15N]-hVDAC1(E73V/C127A/C232S), 33 % w/w DMPC, 10 mM MES, 150 mM sodium chloride, 20 mM MgCl2, 100% H2O | 100% H2O
NMR sample composition 66 % w/w [U-13C; U-15N]-alpha PET u[2H,13C,15N]-hVDAC1(E73V/C127A/C232S), 33 % w/w DMPC, 10 mM MES, 150 mM sodium chloride, 20 mM MgCl2, 100% H2O | 100% H2O
Resolution not provided
8J0O cryo-EM structure of human EMC and VDAC Deposited 2023-04-11 Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain K 1–283（283 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.32 Å
9PFZ Architecture of human Voltage Dependent Anion Channel 1 in nanodiscs Deposited 2025-07-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–283（283 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；25 mM NaPi, 100 mM NaCl, pH 7.0
cryo-EM vitrification conditions Cryogen ETHANE；3.0 uL sample, blot time 3sec, Blotforce 1, Blot total 1,
Resolution 5.40 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.