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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P30988 New Search
32PDB entries
35Biological assembly
35chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5II0 Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue Deposited 2016-03-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 25–144（120 aa） Fragment：ectodomain UNP residues 25-144
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.1 M Hepes, pH 7.5, 4.3 M sodium chloride, 2 M urea
Resolution 2.10 Å R-free 0.205
5II0 Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue Deposited 2016-03-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 25–144（120 aa） Fragment：ectodomain UNP residues 25-144
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.1 M Hepes, pH 7.5, 4.3 M sodium chloride, 2 M urea
Resolution 2.10 Å R-free 0.205
5II0 Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue Deposited 2016-03-01 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 25–144（120 aa） Fragment：ectodomain UNP residues 25-144
Not recorded URE UREA × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.1 M Hepes, pH 7.5, 4.3 M sodium chloride, 2 M urea
Resolution 2.10 Å R-free 0.205
5UZ7 Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex Deposited 2017-02-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
6NIY A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex Deposited 2019-01-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 19–508（490 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.34 Å
6PFO Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32) Deposited 2019-06-21 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 56–159（104 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；293 K；34% Pentaerythritol ethoxylate (15/4 EO/OH), 0.05M Bis-Tris, 0.1M Ammonium sulfate
Resolution 1.78 Å R-free 0.214
6PFO Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32) Deposited 2019-06-21 Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 56–159（104 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；293 K；34% Pentaerythritol ethoxylate (15/4 EO/OH), 0.05M Bis-Tris, 0.1M Ammonium sulfate
Resolution 1.78 Å R-free 0.214
6PGQ Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (22-32) Deposited 2019-06-24 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 57–159（103 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.7；293 K；1.94M Ammonium sulfate, 0.1M Sodium acetate, 15% Ethylene glycol
Resolution 2.85 Å R-free 0.225
7TYF Human Amylin1 Receptor in complex with Gs and rat amylin peptide Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PLM PALMITIC ACID × 9 Y01 CHOLESTEROL HEMISUCCINATE × 2 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 PTY PHOSPHATIDYLETHANOLAMINE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
7TYH Human Amylin2 Receptor in complex with Gs and human calcitonin peptide Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7TYI Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded PLM PALMITIC ACID × 10 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7TYL Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7TYN Calcitonin Receptor in complex with Gs and salmon calcitonin peptide Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 PLM PALMITIC ACID × 13 Y01 CHOLESTEROL HEMISUCCINATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
7TYO Calcitonin receptor in complex with Gs and human calcitonin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
7TYW Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded PLM PALMITIC ACID × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7TYX Human Amylin2 Receptor in complex with Gs and rat amylin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded PLM PALMITIC ACID × 8 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.55 Å
7TYY Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PLM PALMITIC ACID × 5 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7TZF Human Amylin3 Receptor in complex with Gs and rat amylin peptide Deposited 2022-02-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 PLM PALMITIC ACID × 11 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
8F0J Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45 Deposited 2022-11-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded D6M N-hexadecanoyl-L-glutamic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PTY PHOSPHATIDYLETHANOLAMINE × 3 PLM PALMITIC ACID × 8 Y01 CHOLESTEROL HEMISUCCINATE × 2 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.00 Å
8F0K Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 Deposited 2022-11-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 PLM PALMITIC ACID × 8 Y01 CHOLESTEROL HEMISUCCINATE × 2 PTY PHOSPHATIDYLETHANOLAMINE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.90 Å
8F2A Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation) Deposited 2022-11-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
8F2B Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45 Deposited 2022-11-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded D6M N-hexadecanoyl-L-glutamic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PLM PALMITIC ACID × 8 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.00 Å
9AUC Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide Deposited 2024-02-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded PLM PALMITIC ACID × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
9BLB Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation Deposited 2024-04-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9BLC Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation Deposited 2024-04-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9BLW Human amylin1 Receptor in complex with Gs and Cagrilintide backbone (non-acylated) Deposited 2024-05-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9BP3 Human Amylin1 Receptor in complex with Gs and cagrilintide Deposited 2024-05-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded A1B90 icosanedioic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9BQ3 Human Amylin2 Receptor in Complex with Gs and Cagrilintide Deposited 2024-05-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded A1B90 icosanedioic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9BTW Human Amylin3 Receptor in complex with Gs and cagrilintide Deposited 2024-05-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9BUB Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation Deposited 2024-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded A1B90 icosanedioic acid × 1 P42 (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
9BUC Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation (repeat) Deposited 2024-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded A1B90 icosanedioic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9BUD Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation Deposited 2024-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded A1B90 icosanedioic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9BUE Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation (repeat) Deposited 2024-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
9UWM A combined cryo_EM structure of Cagrilintide-CTR-Gs complex Deposited 2025-05-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.04
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9UWQ A combined Cryo_EM structure of Cagrilintide-AMY1R-Gs complex Deposited 2025-05-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 25–474（450 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.04
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.