← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P34896 New Search
8PDB entries
10Biological assembly
21chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BJ4 RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN) Deposited 1998-07-02 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 11–480（470 aa）
Not recorded PLP PYRIDOXAL-5'-PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2 M SODIUM ACETATE, PH 6.5
Resolution 2.65 Å R-free 0.226
6FL5 Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution Deposited 2018-01-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 11–481（471 aa）
Chain D 11–481（471 aa）
Chain G 11–481（471 aa）
Chain J 11–481（471 aa）
Mutation：H135N, R137A, E168N Mutation：H135N, R137A, E168N Mutation：H135N, R137A, E168N Mutation：H135N, R137A, E168N PLP PYRIDOXAL-5'-PHOSPHATE × 4 CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；2 microL of 80microM protein solution in: 20 mM Hepes pH7.2, 250 mM NaCl 5% glycerol + 2 microL of reservoir:0.1 M Na Cacodilate pH6.5 - 1M Na citrate
Resolution 3.60 Å R-free 0.277
6M5W Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid Deposited 2020-03-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–483（483 aa）
Not recorded PLP PYRIDOXAL-5'-PHOSPHATE × 4 DXC (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID × 4 GLY GLYCINE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium chloride, 0.05 M HEPES pH 7.5, and 35% (v/v) pentaerythritol propoxylate (5/4 PO/OH)
Resolution 3.10 Å R-free 0.233
7RJL Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with SHMT Deposited 2021-07-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 270–275（6 aa） Fragment：UNP residues 270-275
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 6 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；35% v/v Tacsimate
Resolution 1.50 Å R-free 0.185
7RJL Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with SHMT Deposited 2021-07-21 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 270–275（6 aa） Fragment：UNP residues 270-275
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；35% v/v Tacsimate
Resolution 1.50 Å R-free 0.185
7RJP Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with SHMT Deposited 2021-07-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 270–275（6 aa） Fragment：UNP residues 270-275
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 1 NA SODIUM ION × 8 CL CHLORIDE ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；25% w/v PEG3350, 0.2 M ammonium acetate, 0.1 M Bis-Tris
Resolution 1.25 Å R-free 0.174
8A11 Cryo-EM structure of the Human SHMT1-RNA complex Deposited 2022-05-30 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–483（483 aa）
Chain B 1–483（483 aa）
Chain C 1–483（483 aa）
Chain D 1–483（483 aa）
Mutation：Chain B has not PLP bond to the active site Mutation：Chain B has not PLP bond to the active site Mutation：Chain B has not PLP bond to the active site Mutation：Chain B has not PLP bond to the active site PLP PYRIDOXAL-5'-PHOSPHATE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blotted for 4 seconds before plunging
Resolution 3.52 Å
8R7H Cryo-EM structure of Human SHMT1 Deposited 2023-11-24 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–483（483 aa）
Chain B 1–483（483 aa）
Chain C 1–483（483 aa）
Chain D 1–483（483 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blotted for 4 seconds before plunging
Resolution 3.29 Å
8XND Crystal structure of serine hydroxymethyltransferase 1 Deposited 2023-12-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 11–480（470 aa）
Chain D 11–480（470 aa）
Not recorded PLP PYRIDOXAL-5'-PHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Sodium HEPES pH 7.5,30 %(v/v) PEG 300
Resolution 3.45 Å R-free 0.192
8XND Crystal structure of serine hydroxymethyltransferase 1 Deposited 2023-12-29 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 11–480（470 aa）
Chain C 11–480（470 aa）
Not recorded PLP PYRIDOXAL-5'-PHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Sodium HEPES pH 7.5,30 %(v/v) PEG 300
Resolution 3.45 Å R-free 0.192

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.