Current Protein Identity：P35247
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1B08 LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT) Deposited 1998-11-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
218–375（158 aa）
Fragment：TRIMERIC FRAGMENT CONSISTING OF LECTIN DOMAINS AND ALPHA-HELICAL COILED-COIL
Chain B
218–375（158 aa）
Fragment：TRIMERIC FRAGMENT CONSISTING OF LECTIN DOMAINS AND ALPHA-HELICAL COILED-COIL
Chain C
218–375（158 aa）
Fragment：TRIMERIC FRAGMENT CONSISTING OF LECTIN DOMAINS AND ALPHA-HELICAL COILED-COIL
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；AN EQUAL AMOUNT OF PROTEIN SOLUTION (8 MG/ML PROTEIN IN 10 MM TRIS 140 MM NACL
1MM CACL2 0.02% (W/V) NAN3 PH 7.5) AND PRECIPITANT BUFFER (10-20% (W/V) PEG
20000 IN 100 MM TRIS PH 6-8) WERE MIXED AND VAPOR EQUILIBRATED AGAINST THE
LATTER., pH 7.00
|
Resolution 2.30 Å R-free 0.271 |
| 1M7L Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D Deposited 2002-07-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
220–257（38 aa）
Fragment：Trimeric Coiled-Coil Domain
Chain B
220–257（38 aa）
Fragment：Trimeric Coiled-Coil Domain
Chain C
220–257（38 aa）
Fragment：Trimeric Coiled-Coil Domain
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.4；303 K
NMR sample composition
90% H2O/10% D2O
|
Resolution not provided |
| 1PW9 High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D Deposited 2003-07-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：Residues 179-355
Chain B
199–375（177 aa）
Fragment：Residues 179-355
Chain C
199–375（177 aa）
Fragment：Residues 179-355
|
Not recorded | CA CALCIUM ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；298 K；PEG 4000, Tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
|
Resolution 1.60 Å R-free 0.249 |
| 1PWB High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D with maltose Deposited 2003-07-01 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：recombinant fragment
Chain B
199–375（177 aa）
Fragment：recombinant fragment
Chain C
199–375（177 aa）
Fragment：recombinant fragment
|
Not recorded | CA CALCIUM ION × 9 GLC alpha-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；PEG 10000, Tris, maltose, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.228 |
| 2GGU crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with maltotriose Deposited 2006-03-24 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：trimeric neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：trimeric neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：trimeric neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；12% PEG 8000, 150mM NaCl, 10mM CaCl2, 100mM HEPES , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.90 Å R-free 0.248 |
| 2GGX Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein D in complex with p-nitrophenyl maltoside Deposited 2006-03-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：Trimeric neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：Trimeric neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：Trimeric neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 NPJ 4-NITROPHENYL 4-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GALACTOPYRANOSIDE × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；12% PEG 8000, 150mM NaCl, 10mM CaCl2, 100mM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.90 Å R-free 0.238 |
| 2ORJ crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with N-acetyl mannosamine Deposited 2007-02-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：head and neck domain
Chain B
223–375（153 aa）
Fragment：head and neck domain
Chain C
223–375（153 aa）
Fragment：head and neck domain
|
Not recorded | CA CALCIUM ION × 9 BM3 2-acetamido-2-deoxy-alpha-D-mannopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150mM NaCl, 10mM CaCl2, 12% PEG 8000, 100mM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.205 |
| 2ORK crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with inositol-1-phosphate Deposited 2007-02-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：head and neck domain
Chain B
223–375（153 aa）
Fragment：head and neck domain
Chain C
223–375（153 aa）
Fragment：head and neck domain
|
Not recorded | CA CALCIUM ION × 9 IPD D-MYO-INOSITOL-1-PHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150mM NaCl, 10mM CaCl2, 12% PEG 8000, 100mM HEPES , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.89 Å R-free 0.226 |
| 2OS9 crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with myoinositol Deposited 2007-02-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：head and neck domain
Chain B
223–375（153 aa）
Fragment：head and neck domain
Chain C
223–375（153 aa）
Fragment：head and neck domain
|
Not recorded | CA CALCIUM ION × 9 INS 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150mM NaCl, 10mM CaCl2, 12% PEG 8000, 100mM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.70 Å R-free 0.223 |
| 2RIA Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with D-glycero-D-manno-heptose Deposited 2007-10-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 289 D-glycero-alpha-D-manno-heptopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；12% PEG 8000, 150MM NACL, 10MM CACL2, 100MM HEPES, PH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.237 |
| 2RIB Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptose Deposited 2007-10-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 GMH L-glycero-alpha-D-manno-heptopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；12% PEG 8000, 150MM NACL, 10MM CACL2, 100MM HEPES , PH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.204 |
| 2RIC Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptopyranosyl-(1-3)-L-glycero-D-manno-heptopyranose Deposited 2007-10-10 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 GMH L-glycero-alpha-D-manno-heptopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；12% PEG 8000, 150MM NACL, 10MM CACL2, 100MM HEPES , PH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.230 |
| 2RID Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with Allyl 7-O-carbamoyl-L-glycero-D-manno-heptopyranoside Deposited 2007-10-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 291 prop-2-en-1-yl 7-O-carbamoyl-L-glycero-alpha-D-manno-heptopyranoside × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；12% PEG 8000, 150MM NACL, 10MM CACL2, 100MM HEPES, PH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.232 |
| 2RIE Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with 2-deoxy-L-glycero-D-manno-heptose Deposited 2007-10-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain B
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
Chain C
223–375（153 aa）
Fragment：neck and carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 293 2-deoxy-beta-L-galacto-heptopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；12% PEG 8000, 150MM NACL, 10MM CACL2, 100MM HEPES, PH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.60 Å R-free 0.212 |
| 3DBZ human surfactant protein D Deposited 2008-06-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：Head and Neck Domain, UNP residues 223-375
Chain B
223–375（153 aa）
Fragment：Head and Neck Domain, UNP residues 223-375
Chain C
223–375（153 aa）
Fragment：Head and Neck Domain, UNP residues 223-375
|
Not recorded | CA CALCIUM ION × 9 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150MM NACL, 10MM CACL2, 12% PEG8000, 100MM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.202 |
| 3G81 Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha methyl mannoside Deposited 2009-02-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：UNP residues 223-375
Chain B
223–375（153 aa）
Fragment：UNP residues 223-375
Chain C
223–375（153 aa）
Fragment：UNP residues 223-375
|
Not recorded | CA CALCIUM ION × 9 MMA methyl alpha-D-mannopyranoside × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150MM NACL, 10MM CACL2, 12% PEG 8000, 100MM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.200 |
| 3G83 Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose. Deposited 2009-02-11 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：UNP residues 223-375
Chain B
223–375（153 aa）
Fragment：UNP residues 223-375
Chain C
223–375（153 aa）
Fragment：UNP residues 223-375
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150MM NACL, 10MM CACL2, 12% PEG 8000, 100MM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 1.90 Å R-free 0.215 |
| 3G84 Crystal structure of the trimeric neck and carbohydrate recognition domain of R343V mutant of human surfactant protein D in complex with alpha 1,2 dimannose. Deposited 2009-02-11 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
223–375（153 aa）
Fragment：UNP residues 223-375
Chain B
223–375（153 aa）
Fragment：UNP residues 223-375
Chain C
223–375（153 aa）
Fragment：UNP residues 223-375
|
Mutation：R343V Mutation：R343V Mutation：R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；150MM NACL, 10MM CACL2, 12% PEG 8000, 100MM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.30 Å R-free 0.191 |
| 3IKN Crystal structure of galactose bound trimeric human lung surfactant protein D Deposited 2009-08-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：UNP residues 199-375
Chain B
199–375（177 aa）
Fragment：UNP residues 199-375
Chain C
199–375（177 aa）
Fragment：UNP residues 199-375
|
Mutation：P180S Mutation：P180S Mutation：P180S | CA CALCIUM ION × 10 GAL beta-D-galactopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG 4000, tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.60 Å R-free 0.215 |
| 3IKP Crystal structure of inositol phosphate bound trimeric human lung surfactant protein D Deposited 2009-08-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：UNP residues 199-375
Chain B
199–375（177 aa）
Fragment：UNP residues 199-375
Chain C
199–375（177 aa）
Fragment：UNP residues 199-375
|
Mutation：P180S Mutation：P180S Mutation：P180S | CA CALCIUM ION × 10 IPD D-MYO-INOSITOL-1-PHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG 4000, tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.75 Å R-free 0.213 |
| 3IKQ Crystal structure of alpha 1-2 mannobiose bound trimeric human lung surfactant protein D Deposited 2009-08-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：UNP residues 199-375
Chain B
199–375（177 aa）
Fragment：UNP residues 199-375
Chain C
199–375（177 aa）
Fragment：UNP residues 199-375
|
Mutation：P180S Mutation：P180S Mutation：P180S | CA CALCIUM ION × 10 MAN alpha-D-mannopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG 4000, tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.25 Å R-free 0.239 |
| 3IKR Crystal structure of alpha 1-4 mannobiose bound trimeric human lung surfactant protein D Deposited 2009-08-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
199–375（177 aa）
Fragment：UNP residues 199-375
Chain B
199–375（177 aa）
Fragment：UNP residues 199-375
Chain C
199–375（177 aa）
Fragment：UNP residues 199-375
|
Mutation：P180S Mutation：P180S Mutation：P180S | CA CALCIUM ION × 10 MAN alpha-D-mannopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG 4000, tris, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.65 Å R-free 0.212 |
| 4E52 Crystal structure of Haemophilus Eagan 4A polysaccharide bound human lung surfactant protein D Deposited 2012-03-13 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；PEG 4000, Tris, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.210 |
| 4M17 Crystal Structure of Surfactant Protein-D D325A/R343V mutant Deposited 2013-08-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain B
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain C
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.10 Å R-free 0.188 |
| 4M17 Crystal Structure of Surfactant Protein-D D325A/R343V mutant Deposited 2013-08-02 | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain E
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain F
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.10 Å R-free 0.188 |
| 4M17 Crystal Structure of Surfactant Protein-D D325A/R343V mutant Deposited 2013-08-02 | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain G
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain H
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain I
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.10 Å R-free 0.188 |
| 4M17 Crystal Structure of Surfactant Protein-D D325A/R343V mutant Deposited 2013-08-02 | Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain J
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain K
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain L
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.10 Å R-free 0.188 |
| 4M18 Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man) Deposited 2013-08-02 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain B
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain C
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.20 Å R-free 0.222 |
| 4M18 Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man) Deposited 2013-08-02 | Assembly 2 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain E
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain F
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.20 Å R-free 0.222 |
| 4M18 Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man) Deposited 2013-08-02 | Assembly 3 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain G
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain H
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain I
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.20 Å R-free 0.222 |
| 4M18 Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man) Deposited 2013-08-02 | Assembly 4 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain J
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain K
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
Chain L
229–375（147 aa）
Fragment：neck and carbohydrate recognition domain (UNP residues 229-375)
|
Mutation：D325A/R343V Mutation：D325A/R343V Mutation：D325A/R343V | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；Purified D325A+R343V (12-15 mg/mL in 20 mM HEPES, pH 7.5, 150 mM sodium chloride, 10 mM calcium acetate) + reservoir solution (0.1 M HEPES, pH 7.5, 0.25 M sodium chloride, 20-22% w/v PEG3350), VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.20 Å R-free 0.222 |
| 5OXR Crystal structure of human lung surfactant protein D trimeric fragment with bound ligand Salmonella enterica Minnesota R7 oligosaccharide Deposited 2017-09-07 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1M Tris pH 7.0, 16% PEG 10000
|
Resolution 1.75 Å R-free 0.196 |
| 5OXS Crystal structure of human lung surfactant protein D trimeric fragment with bound ligand Salmonella enterica Minnesota R5 oligosaccharide Deposited 2017-09-07 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；0.1M Tris pH 8.0, 16% PEG 6000
|
Resolution 1.65 Å R-free 0.187 |
| 9QVU Crystal structure of human lung surfactant protein D trimeric fragment with bound synthetic HepI-(1,5)-KdoI ligand Deposited 2025-04-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 GMH L-glycero-alpha-D-manno-heptopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；16% PEG 4000 and 0.1 M Tris pH 8.0
|
Resolution 1.75 Å R-free 0.206 |
| 9QW2 Crystal structure of human lung surfactant protein D trimeric fragment with bound synthetic HepII-HepI-PhosI ligand Deposited 2025-04-14 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；16% PEG 4000 and 0.1 M Tris pH 8.0
|
Resolution 1.92 Å R-free 0.212 |
| 9QW3 Crystal structure of human lung surfactant protein D trimeric fragment with bound synthetic HepIII-HepII-HepI ligand Deposited 2025-04-14 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 A1JBO ~{N}-[4-[2-[(2~{S},3~{S},4~{S},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxyethyl]phenyl]-2,2,2-tris(fluoranyl)ethanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；16% PEG 4000 and 0.1 M Tris pH 8.0
|
Resolution 1.63 Å R-free 0.199 |
| 9QW4 Crystal structure of human lung surfactant protein D trimeric fragment with bound synthetic PhosII-HepII-HepI ligand Deposited 2025-04-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain B
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
Chain C
201–375（175 aa）
Fragment：Trimeric neck + carbohydrate recognition domain
|
Not recorded | CA CALCIUM ION × 9 A1JBS [(2~{R},3~{S},4~{R},5~{S},6~{S})-2-[(1~{S})-1,2-bis(oxidanyl)ethyl]-6-[(2~{R},3~{R},4~{S},5~{S},6~{S})-2-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,5-bis(oxidanyl)-6-[2-[4-[2,2,2-tris(fluoranyl)ethanoylamino]phenyl]ethoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxan-3-yl] dihydrogen phosphate × 1 GMH L-glycero-alpha-D-manno-heptopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；16% PEG 4000 and 0.1 M Tris pH 8.0
|
Resolution 1.85 Å R-free 0.201 |