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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P42224 New Search
10PDB entries
17Biological assembly
22chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BF5 TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX Deposited 1998-05-27 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 136–683（548 aa） Fragment：RESIDUES 136-710
Mutation：PHOSPHORYLATED TYR 701 Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；pH 5.00, VAPOR DIFFUSION, HANGING DROP, temperature 277.00K
Resolution 2.90 Å R-free 0.293
1YVL Structure of Unphosphorylated STAT1 Deposited 2005-02-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–683（683 aa） Fragment：residues 1-683
Not recorded AU GOLD ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；HEPES, PEG 400, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.00 Å R-free 0.281
1YVL Structure of Unphosphorylated STAT1 Deposited 2005-02-16 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–683（683 aa） Fragment：residues 1-683
Not recorded AU GOLD ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；HEPES, PEG 400, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.00 Å R-free 0.281
1YVL Structure of Unphosphorylated STAT1 Deposited 2005-02-16 Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–683（683 aa） Fragment：residues 1-683
Chain B 1–683（683 aa） Fragment：residues 1-683
Not recorded AU GOLD ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；HEPES, PEG 400, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.00 Å R-free 0.281
1YVL Structure of Unphosphorylated STAT1 Deposited 2005-02-16 Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–683（683 aa） Fragment：residues 1-683
Chain B 1–683（683 aa） Fragment：residues 1-683
Not recorded AU GOLD ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；HEPES, PEG 400, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.00 Å R-free 0.281
2KA6 NMR structure of the CBP-TAZ2/STAT1-TAD complex Deposited 2008-10-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 710–750（41 aa） Fragment：UNP residues 710 to 750
Not recorded ZN ZINC ION × 3 SOLUTION NMR
NMR measurement conditions pH 6.8；290 K；Ionic strength (raw mmCIF value) 0.05；Pressure ambient
NMR sample composition 1 mM [U-100% 15N] TAZ2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3WWT Crystal Structure of the Y3:STAT1ND complex Deposited 2014-06-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–126（126 aa） Fragment：N-terminal domain, UNP residues 1-126
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；298 K；30% PEG400, 0.2M CaCl2, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.00 Å R-free 0.237
7NUF Vaccinia virus protein 018 in complex with STAT1 Deposited 2021-03-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 132–684（553 aa）
Mutation：Delta183-190, H182A, E393A, E394A SO4 SULFATE ION × 1 ACE ACETYL GROUP × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；300:300 nl drop of protein:condition Protein: 10 mg/ml STAT1:peptide complex in 20 mM Tris pH8.0, 300 mM NaCl, 1 mM EDTA, 5 mM TCEP Condition: 16% PEG 3350 (w/v), 175 mM KCl, 125 mM NH4SO4,
Resolution 2.00 Å R-free 0.256
8D3F Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST Deposited 2022-06-01 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 132–713（582 aa） Fragment：STAT1-binding region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Bis-Tris pH 6.3-6.0, 3 M sodium chloride and 50 mM sodium citrate tribasic
Resolution 2.97 Å R-free 0.288
8YYU A tetrameric STAT1-DNA complex Deposited 2024-04-04 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: dodecameric（12） Consistent with all polymers
Chain A 1–750（750 aa）
Chain D 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.84 Å
8YYU A tetrameric STAT1-DNA complex Deposited 2024-04-04 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: hexameric（6） Consistent with all polymers
Chain A 1–750（750 aa）
Chain D 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.84 Å
8YYU A tetrameric STAT1-DNA complex Deposited 2024-04-04 Assembly 3 Protein–DNA Homooligomer；Protein × 2 PDB declaration: hexameric（6） Consistent with all polymers
Chain A 1–750（750 aa）
Chain D 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.84 Å
8YYV A dimeric STAT1-DNA complex Deposited 2024-04-04 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: hexameric（6） Consistent with all polymers
Chain A 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
8YYV A dimeric STAT1-DNA complex Deposited 2024-04-04 Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
8YYV A dimeric STAT1-DNA complex Deposited 2024-04-04 Assembly 3 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–750（750 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
9IFX Beta-hairpin macrocyclic peptide in complex with STAT1 Deposited 2025-02-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 132–684（553 aa）
Not recorded OXE ORTHO-XYLENE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Crystallisation condition: 4% v/v TacsimateTM pH 5.0 12% w/v Polyethylene glycol 3,350 Protein:peptide complex: 5 mg /ml 20 mM Tris pH 8.0, 300 mM NaCl
Resolution 3.64 Å R-free 0.271
9IGA Beta-hairpin macrocyclic peptide in complex with STAT1 Deposited 2025-02-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 132–684（553 aa）
Mutation：132-684,delta183-190,H182A,E393A,E394A OXE ORTHO-XYLENE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Crystallisation conditions: 0.1 M Bis-Tris 5.5 0.2 M Ammonium acetate 25 % w/v PEG 3350 Protein:peptide complex: 5 mg ml 20 mM Tris pH 8.0, 300 mM NaCl
Resolution 2.80 Å R-free 0.313

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.