Current Protein Identity：P49773
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1AV5 PKCI-SUBSTRATE ANALOG Deposited 1997-09-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
Chain B
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | AP2 PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；GROWN FROM PEG8K PH6.5
|
Resolution 2.00 Å R-free 0.279 |
| 1KPA PKCI-1-ZINC Deposited 1996-01-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
Chain B
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å R-free 0.261 |
| 1KPB PKCI-1-APO Deposited 1996-01-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
Chain B
1–125（125 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å R-free 0.248 |
| 1KPC PKCI-1-APO+ZINC Deposited 1996-01-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
Chain B
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.309 |
| 1KPC PKCI-1-APO+ZINC Deposited 1996-01-06 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–125（125 aa）
Chain D
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.309 |
| 1KPE PKCI-TRANSITION STATE ANALOG Deposited 1997-09-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
Chain B
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ADW ADENOSINE-5'-DITUNGSTATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；GROWN FROM PEG8K PH6.5
THE PENTACOVALENT TRANSITION STATE ANALOG WAS PREPARED BY
SOAKING SODIUM TUNGSTATE AND ADENOSINE INTO THE CRYSTAL.
THE COMPOUNDS WERE FOUND TO BIND IN THE ACTIVE SITE OF
CHAIN B. THE ACTIVE SITE OF CHAIN A IS BLOCKED BY A
LATTICE CONTACT AND IS NOT AVAILABLE TO THE SUBSTRATE.
THREE NEW BONDS ARE FORMED UPON SOAKING THIS MIXTURE INTO
THE PKCI CRYSTALS: ONE BETWEEN THE NE OF HIS B 112 AND THE
ALPHA TUNGSTATE, ONE BETWEEN THE ALPHA AND BETA TUNGSTATE
IONS, AND ONE BETWEEN THE NUCLEOSIDE RIBOSE AND THE ALPHA
TUNGSTATE ION.
|
Resolution 1.80 Å R-free 0.223 |
| 1KPF PKCI-SUBSTRATE ANALOG Deposited 1997-09-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–125（125 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | AMP ADENOSINE MONOPHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；COCRYSTALLIZED WITH AMP FROM PEG8K PH6.5
|
Resolution 1.50 Å R-free 0.240 |
| 3TW2 High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group Deposited 2011-09-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；278 K；19% PEG 8000, 0.1M sodium cacodylate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 1.38 Å R-free 0.161 |
| 4EQE Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Lys-AMS Deposited 2012-04-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 KAA 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；25-28% PEG3350, 0.1 M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.52 Å R-free 0.162 |
| 4EQG Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Ala-AMS Deposited 2012-04-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | A5A '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；25-28% PEG3350, 0.1 M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.52 Å R-free 0.164 |
| 4EQH Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Trp-AMS Deposited 2012-04-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | WSA 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；25-28% PEG3350, 0.1 M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.67 Å R-free 0.173 |
| 4ZKL Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog) Deposited 2015-04-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Fragment：UNP residues 1-126
Chain B
1–126（126 aa）
Fragment：UNP residues 1-126
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 JB6 (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；281 K；19% w/v PEG4000, 0.1 M sodium cacodylate pH 5.5
|
Resolution 2.34 Å R-free 0.239 |
| 4ZKL Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog) Deposited 2015-04-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–126（126 aa）
Fragment：UNP residues 1-126
Chain D
1–126（126 aa）
Fragment：UNP residues 1-126
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；281 K；19% w/v PEG4000, 0.1 M sodium cacodylate pH 5.5
|
Resolution 2.34 Å R-free 0.239 |
| 4ZKV Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A at P21 space group Deposited 2015-04-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；281 K；18% PEG 4000, 0.1M sodium cacodylate pH 6.8
|
Resolution 1.92 Å R-free 0.287 |
| 4ZKV Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A at P21 space group Deposited 2015-04-30 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–126（126 aa）
Chain D
1–126（126 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；281 K；18% PEG 4000, 0.1M sodium cacodylate pH 6.8
|
Resolution 1.92 Å R-free 0.287 |
| 5ED3 crystal structure of human Hint1 complexing with AP5A Deposited 2015-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；PEG3350, HEPES
|
Resolution 1.31 Å R-free 0.155 |
| 5ED6 crystal structure of human Hint1 H114A mutant complexing with ATP Deposited 2015-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | AMP ADENOSINE MONOPHOSPHATE × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；PEG3350, HEPES
|
Resolution 1.52 Å R-free 0.164 |
| 5EMT Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-copper complex Deposited 2015-11-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | CU COPPER (II) ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；100 mM MES, 39% PEG 8000,
|
Resolution 1.50 Å R-free 0.165 |
| 5I2E Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine Deposited 2016-02-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | 67D 3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.1；293 K；100 mM MES, 35% PEG 8000
|
Resolution 1.60 Å R-free 0.199 |
| 5I2F Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) with bound sulfamide inhibitor Bio-AMS Deposited 2016-02-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 BS5 5'-deoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.9；293 K；100 mM MES, 33% PEG 8000
|
Resolution 1.25 Å R-free 0.175 |
| 5IPB Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Deposited 2016-03-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.7；293 K；100 mM MES, 33% PEG 8000
|
Resolution 1.55 Å R-free 0.193 |
| 5IPC Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside thiophosphoramidate substrate complex Deposited 2016-03-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 6CE 5'-S-[(S)-hydroxy{[2-(1H-indol-3-yl)ethyl]amino}phosphoryl]-5'-thioguanosine × 1 EDO 1,2-ETHANEDIOL × 3 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；100 mM MES, 37% PEG 8000
|
Resolution 1.30 Å R-free 0.170 |
| 5IPD Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) nucleoside thiophosphoramidate covalent intermediate complex Deposited 2016-03-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | 6CG 5'-S-phosphono-5'-thioguanosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.4；293 K；100 mM MES, 34% PEG 8000
|
Resolution 1.75 Å R-free 0.188 |
| 5IPE Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) nucleoside thiophosphoramidate catalytic product complex Deposited 2016-03-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | 6CG 5'-S-phosphono-5'-thioguanosine × 1 CL CHLORIDE ION × 1 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.1；293 K；100 mM MES, 39% PEG 8000
|
Resolution 1.45 Å R-free 0.181 |
| 5KLY Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant adenosine nucleoside phosphoramidate substrate complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 6UR [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]p hosphonamidic acid × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；293 K；100 mM MES, 32% PEG 8000
|
Resolution 1.30 Å R-free 0.171 |
| 5KLZ Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) AMP catalytic product complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 37% PEG 8000,
|
Resolution 1.50 Å R-free 0.184 |
| 5KM0 Human Histidine Triad Nucleotide Binding Protein 1 (hHint) IMP complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | IMP INOSINIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 34% PEG 8000
|
Resolution 1.53 Å R-free 0.223 |
| 5KM0 Human Histidine Triad Nucleotide Binding Protein 1 (hHint) IMP complex Deposited 2016-06-26 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–126（126 aa）
Chain D
1–126（126 aa）
|
Not recorded | IMP INOSINIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 34% PEG 8000
|
Resolution 1.53 Å R-free 0.223 |
| 5KM1 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) GMP catalytic product complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | 5GP GUANOSINE-5'-MONOPHOSPHATE × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；100 mM MES, 31% PEG 8000,
|
Resolution 1.65 Å R-free 0.180 |
| 5KM2 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) CMP catalytic product complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | C5P CYTIDINE-5'-MONOPHOSPHATE × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；100 mM MES, 38% PEG 8000,
|
Resolution 1.25 Å R-free 0.173 |
| 5KM3 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) UMP catalytic product complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | U5P URIDINE-5'-MONOPHOSPHATE × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；100 mM MES, 38% PEG 8000,
|
Resolution 1.20 Å R-free 0.181 |
| 5KM4 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-5-Iodo-UMP complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | IU 5-IODOURIDINE-5'-MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 34-39% PEG 8000,
|
Resolution 1.40 Å R-free 0.200 |
| 5KM6 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
|
Mutation：H112N | 6US [(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；100 mM MES, 32% PEG 8000
|
Resolution 1.60 Å R-free 0.191 |
| 5KMA Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Trp phosphoramidate substrate complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 777 [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-ethyl-phosphonamidic acid × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；293 K；100 mM MES, 32% PEG 8000
|
Resolution 1.55 Å R-free 0.186 |
| 5KMB Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Trp phosphoramidate substrate complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 6UT [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~ {S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]phosphonamidic acid × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 33% PEG 8000
|
Resolution 1.60 Å R-free 0.175 |
| 5KMC Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex Deposited 2016-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | 6UU [2-(1~{H}-indol-3-yl)ethylamino]phosphonic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；100 mM MES, 39% PEG 8000,
|
Resolution 1.35 Å R-free 0.174 |
| 5O8I Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, and refined to 1.27 A Deposited 2017-06-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；281 K；20% w/v PEG 3350, 0.1 M Bis-Tris Propane pH 8.5, 0.2 M Sodium/Potassium Phosphate
|
Resolution 1.27 Å R-free 0.133 |
| 5WA8 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex Deposited 2017-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 9ZA [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM MES, 38% PEG 8000
|
Resolution 1.30 Å R-free 0.170 |
| 5WA9 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex Deposited 2017-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H112N Mutation：H112N | 9ZD [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 mM MES, 36% PEG 8000
|
Resolution 1.15 Å R-free 0.152 |
| 5WAA Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) C84R mutant Deposited 2017-06-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：C84R Mutation：C84R | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；100 mM HEPES, 35% PEG 8000
|
Resolution 1.10 Å R-free 0.149 |
| 6B42 Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) 2'-deoxy-AMP complex at 1.13A resolution Deposited 2017-09-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
|
Not recorded | D5M 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；100 MM MES, 33% PEG 8000
|
Resolution 1.13 Å R-free 0.160 |
| 6G9Z Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, with visible extended fragment of N-terminus Deposited 2018-04-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | LMR (2S)-2-hydroxybutanedioic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；281 K；25% PEG 1500, 0.1 M MMT Buffer pH 7.0
|
Resolution 1.43 Å R-free 0.277 |
| 6J53 Crystal structure of human HINT1 complexing with ATP Deposited 2019-01-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；HEPES pH 7.5, PEG 3350
|
Resolution 1.52 Å R-free 0.169 |
| 6J58 Crystal structure of human HINT1 complexing with AP4A Deposited 2019-01-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；HEPES pH 7.5, PEG 3350
|
Resolution 1.52 Å R-free 0.170 |
| 6J5S Crystal structure of human HINT1 mutant complexing with AP5A Deposited 2019-01-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | AP5 BIS(ADENOSINE)-5'-PENTAPHOSPHATE × 1 ESA ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；HEPES pH 7.5, PEG 3350
|
Resolution 1.02 Å R-free 0.175 |
| 6J5Z Crystal structure of human HINT1 mutant complexing with AP3A Deposited 2019-01-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | ESA ETHANESULFONIC ACID × 1 ADN ADENOSINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；HEPES pH 7.5, PEG 3350
|
Resolution 1.30 Å R-free 0.170 |
| 6J5Z Crystal structure of human HINT1 mutant complexing with AP3A Deposited 2019-01-12 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–126（126 aa）
Chain D
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | ADN ADENOSINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；HEPES pH 7.5, PEG 3350
|
Resolution 1.30 Å R-free 0.170 |
| 6J64 Crystal structure of human HINT1 mutant complexing with AP4A Deposited 2019-01-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | TAU 2-AMINOETHANESULFONIC ACID × 1 B4P BIS(ADENOSINE)-5'-TETRAPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；HEPES pH 7.5, PEG3350
|
Resolution 0.95 Å R-free 0.175 |
| 6J65 Crystal structure of human HINT1 mutant complexing with AP4A II Deposited 2019-01-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | B4P BIS(ADENOSINE)-5'-TETRAPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；HEPES pH 7.5, PEG3 350
|
Resolution 1.42 Å R-free 0.206 |
| 6J65 Crystal structure of human HINT1 mutant complexing with AP4A II Deposited 2019-01-14 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1–126（126 aa）
Chain E
1–126（126 aa）
|
Mutation：H114A Mutation：H114A | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；HEPES pH 7.5, PEG3 350
|
Resolution 1.42 Å R-free 0.206 |
| 6N3V Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Ethyl]Carbamoyl Guanosine Deposited 2018-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | KB7 5'-O-(ethylcarbamoyl)guanosine × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.3；293 K；100 mM MES, 35% PEG 8000
|
Resolution 1.45 Å R-free 0.174 |
| 6N3W Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[3-Phenyl-1-Ethyl]Carbamoyl Guanosine Deposited 2018-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | KBJ 5'-O-[(2-phenylethyl)carbamoyl]guanosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.3；293 K；100 mM MES, 35% PEG 8000
|
Resolution 1.75 Å R-free 0.190 |
| 6N3X Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Benzyl]Carbamoyl Guanosine Deposited 2018-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | KBD 5'-O-(benzylcarbamoyl)guanosine × 1 EDO 1,2-ETHANEDIOL × 2 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.3；293 K；100 mM MES, 35% PEG 8000
|
Resolution 1.10 Å R-free 0.173 |
| 6N3Y Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Guanosine Deposited 2018-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | HHJ 5'-O-{[2-(1H-indol-3-yl)ethyl]carbamoyl}guanosine × 1 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.3；293 K；100 mM MES, 35% PEG 8000
|
Resolution 1.80 Å R-free 0.247 |
| 6YQM Human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with dGMP and refined to 1.02 A Deposited 2020-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain AAA
1–126（126 aa）
Chain BBB
1–126（126 aa）
|
Not recorded | DGP 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE × 1 PEG DI(HYDROXYETHYL)ETHER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.7；281 K；16 % (w/v) PEG 4000, 0.1 M sodium cacodylate
|
Resolution 1.02 Å R-free 0.136 |
| 7Q2U The crystal structure of the HINT1 Q62A mutant. Deposited 2021-10-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain AAA
1–126（126 aa）
Chain BBB
1–126（126 aa）
|
Mutation：Q62A Mutation：Q62A | P6G HEXAETHYLENE GLYCOL × 1 CAC CACODYLATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；281 K；16% (w/v) PEG3350, 0.2 M sodium citrate, 0.1 M sodium cacodylate pH 7.0
|
Resolution 2.27 Å R-free 0.220 |
| 7Q2U The crystal structure of the HINT1 Q62A mutant. Deposited 2021-10-26 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain CCC
1–126（126 aa）
Chain DDD
1–126（126 aa）
|
Mutation：Q62A Mutation：Q62A | CAC CACODYLATE ION × 1 PG4 TETRAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；281 K；16% (w/v) PEG3350, 0.2 M sodium citrate, 0.1 M sodium cacodylate pH 7.0
|
Resolution 2.27 Å R-free 0.220 |
| 8P8P Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Ethenoadenosine Deposited 2023-06-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | X7I [(2~{R},3~{S},4~{R},5~{R})-5-imidazo[2,1-f]purin-3-yl-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[2-(1~{H}-indol-3-yl)ethyl]carbamate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；10% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 1.90 Å R-free 0.190 |
| 8PA6 Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine Deposited 2023-06-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | XKB 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；12% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 1.58 Å R-free 0.191 |
| 8PA9 Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine Deposited 2023-06-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | XKF 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；12% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 1.50 Å R-free 0.179 |
| 8PAF Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine Deposited 2023-06-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | XKK 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；14% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 2.10 Å R-free 0.187 |
| 8PAI Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine Deposited 2023-06-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | XKO 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；10% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 1.80 Å R-free 0.191 |
| 8PWK human HINT1 in complex with compound AT8003 Deposited 2023-07-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | I0H [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；30-50% PEG 2K MME
0,1M Sodium cacodylate
|
Resolution 2.10 Å R-free 0.239 |
| 8WZD The Crystal Structure of PKCi from Biortus Deposited 2023-11-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1M Na2tartrate, 0.1M Hepes pH7.0, 20% SOKALAN PA25 CL
|
Resolution 2.05 Å R-free 0.217 |
| 9GYP Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with KV24 Deposited 2024-10-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | A1IQU ~{N}-oxidanyl-4-(5~{H}-pyrrolo[1,2-a]quinoxalin-4-yl)benzamide × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；10% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 1.80 Å R-free 0.191 |
| 9GYQ Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with KV30 Deposited 2024-10-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | A1IQV ~{N}-oxidanyl-4-phenanthridin-6-yl-benzamide × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；281 K；10% w/v PEG4000, 0.1 M sodium cacodylate pH 6.0
|
Resolution 2.00 Å R-free 0.188 |
| 9QRO HINT1 complexed with GS-441524-MP Deposited 2025-04-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.58 Å R-free 0.212 |
| 9QTC HINT1 complexed with GS-441524 Deposited 2025-04-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–126（126 aa）
Chain B
1–126（126 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.30 Å R-free 0.188 |