Current Protein Identity：P49916
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 10YE DNA Ligase IIIa bound to nucleosome containing a nick at SHL0 Deposited 2026-02-12 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 12-meric（12） Consistent with all polymers |
Chain L
474–681（208 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 10YF DNA Ligase IIIa bound to nucleosome containing a nick at SHL-2 (composite) Deposited 2026-02-12 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 12-meric（12） Consistent with all polymers |
Chain L
474–681（208 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution not provided |
| 10YG DNA Ligase IIIa bound to a nucleosome containing a nick at SHL-4 (composite) Deposited 2026-02-12 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 12-meric（12） Consistent with all polymers |
Chain L
474–681（208 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution not provided |
| 10YH DNA Ligase IIIa bound to a nucleosome containing a nick at SHL-6 (composite) Deposited 2026-02-12 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 12-meric（12） Consistent with all polymers |
Chain L
474–681（208 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 10YI XRCC1-DNA Ligase IIIa complex bound to a nucleosome containing a nick at SHL-6 (composite) Deposited 2026-02-12 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 12-meric（12） Consistent with all polymers |
Chain L
474–681（208 aa）
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 1IMO NMR STRUCTURE OF HUMAN DNA LIGASE IIIALPHA BRCT DOMAIN Deposited 2001-05-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
835–922（88 aa）
Fragment：BRCT DOMAIN
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.6；288 K；Ionic strength (raw mmCIF value) 0.4-1.0 mM；Pressure ambient
NMR sample composition
50 mM NaH2PO4, 150 mM NaCl, 25 mM d10-DTTT | 90-95% H2O and 10-5% D2O
|
Resolution not provided |
| 1IN1 NMR STRUCTURE OF HUMAN DNA LIGASE IIIALPHA BRCT DOMAIN Deposited 2001-05-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
835–922（88 aa）
Fragment：BRCT DOMAIN
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.6；288 K；Ionic strength (raw mmCIF value) 0.4-1.0 mM；Pressure ambient
NMR sample composition
50 mM NaH2PO4, 150 mM NaCl, 25 mM d10-DTT | 90-95% H2O and 10-5% D2O
|
Resolution not provided |
| 1UW0 Solution structure of the zinc-finger domain from DNA ligase IIIa Deposited 2004-01-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–117（117 aa）
Fragment：ZINC-FINGER DOMAIN, RESIDUES 1-117
|
Not recorded | ZN ZINC ION × 1 | SOLUTION NMR |
NMR measurement conditions
pH 6.8；300 K；Pressure 1
|
Resolution not provided |
| 3L2P Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States Deposited 2009-12-15 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
257–833（577 aa）
Fragment：UNP residues 257-833
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.6；295 K；1.8 M ammonium sulfate, 0.1M sodium acetate pH 5.6, VAPOR DIFFUSION, temperature 295K
|
Resolution 3.00 Å R-free 0.271 |
| 3PC7 X-ray crystal structure of the DNA ligase III-alpha BRCT domain. Deposited 2010-10-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
924–1009（86 aa）
Fragment：unp residues 924-1009
|
Mutation：C842S, C921S Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；25 % polyethylene glycol 3350, 0.1 M BisTris, 0.25 M ammonium acetate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.198 |
| 3PC7 X-ray crystal structure of the DNA ligase III-alpha BRCT domain. Deposited 2010-10-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
924–1009（86 aa）
Fragment：unp residues 924-1009
|
Mutation：C842S, C921S Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；25 % polyethylene glycol 3350, 0.1 M BisTris, 0.25 M ammonium acetate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.198 |
| 3PC8 X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains. Deposited 2010-10-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
924–1008（85 aa）
Fragment：unp residues 924-1008
Chain D
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Mutation：C842S, C921S Mutation：C842S, C921S | MG MAGNESIUM ION × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30% PEG 4000, 0.1M Tris, and 0.2 M MgCl2 , pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.31 Å R-free 0.246 |
| 3PC8 X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains. Deposited 2010-10-21 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Mutation：C842S, C921S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30% PEG 4000, 0.1M Tris, and 0.2 M MgCl2 , pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.31 Å R-free 0.246 |
| 3PC8 X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains. Deposited 2010-10-21 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Mutation：C842S, C921S | MG MAGNESIUM ION × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30% PEG 4000, 0.1M Tris, and 0.2 M MgCl2 , pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.31 Å R-free 0.246 |
| 3QVG XRCC1 bound to DNA ligase Deposited 2011-02-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
924–1008（85 aa）
Fragment：unp residues 924-1008
Chain C
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30 % PEG4000, 0.1 M Tris, 0.2 M NaAcetate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.26 Å R-free 0.270 |
| 3QVG XRCC1 bound to DNA ligase Deposited 2011-02-25 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30 % PEG4000, 0.1 M Tris, 0.2 M NaAcetate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.26 Å R-free 0.270 |
| 3QVG XRCC1 bound to DNA ligase Deposited 2011-02-25 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
924–1008（85 aa）
Fragment：unp residues 924-1008
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；30 % PEG4000, 0.1 M Tris, 0.2 M NaAcetate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.26 Å R-free 0.270 |
| 6WH1 Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains Deposited 2020-04-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
932–1009（78 aa）
Fragment：BRCT domain
|
Mutation：C922S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；8-10% isopropanol and 0.1M Bis-Tris pH 5.5
|
Resolution 2.40 Å R-free 0.272 |