Current Protein Identity：P83303
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1MB6 Three dimensional solution structure of huwentoxin-IV by 2D 1H-NMR Deposited 2002-08-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–35（35 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；300 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition
5MM HUWENTOXIN-IV MMOL/L PHOSPHATE BUFFER; 90%H2O, 10%D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M4X Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Deposited 2013-02-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–87（35 aa）
Fragment：unp residues 53-87
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；25 K；Pressure ambient
NMR sample composition
2 mM HWTX-IV, 20 mM sodium phosphate, 150 uM sodium azide, 100 uM EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M4Z Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Deposited 2013-02-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–87（35 aa）
Fragment：unp residues 53-87
|
Mutation：A82W | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；298 K；Pressure ambient
NMR sample composition
2 mM entity, 20 mM sodium phosphate, 150 uM sodium azide, 100 uM [U-2H] EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M50 Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Deposited 2013-02-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–87（35 aa）
Fragment：unp residues 53-87
|
Mutation：A82K | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；298 K；Pressure ambient
NMR sample composition
2 mM entity, 20 mM sodium phosphate, 150 uM sodium azide, 100 uM [U-99% 2H] EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5T3M Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7 Deposited 2016-08-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
53–87（35 aa）
Fragment：residues 53-87
|
Mutation：E1G,E4G,Y33W | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition
400 uM [U-99% 13C; U-99% 15N] [m3]-HwTx-IV, 20 mM sodium acetate, 5 % [U-100% 2H] D2O, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 5TLR Solution NMR structure of gHwTx-IV Deposited 2016-10-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
54–87（34 aa）
Fragment：UNP residues 54-87
|
Mutation：E56G, Y58W, F85W Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4；298 K；Pressure ambient
NMR measurement conditions
pH 4；298 K；Pressure ambient
NMR measurement conditions
pH 4；283 K；Pressure ambient
NMR sample composition
90 % H2O, 10 % D2O, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
100 % D2O, 100% D2O | 100% D2O
|
Resolution not provided |
| 6W6O NaChBac-Nav1.7VSDII chimera and HWTX-IV complex Deposited 2020-03-17 | Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain C
53–87（35 aa）
Fragment：UNP residues 53-87
Chain E
53–87（35 aa）
Fragment：UNP residues 53-87
Chain G
53–87（35 aa）
Fragment：UNP residues 53-87
Chain I
53–87（35 aa）
Fragment：UNP residues 53-87
|
Not recorded | POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 12 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 10
cryo-EM vitrification conditions
Cryogen ETHANE；Blotted for 5 seconds before plunging
|
Resolution 3.20 Å |
| 7K48 Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV Deposited 2020-09-15 | Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain E
53–87（35 aa）
Chain F
53–87（35 aa）
Chain G
53–87（35 aa）
Chain H
53–87（35 aa）
|
Mutation：E1G, E4G, Y33W Mutation：E1G, E4G, Y33W Mutation：E1G, E4G, Y33W Mutation：E1G, E4G, Y33W | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Blot for 2.5-4.0 seconds before plunging
|
Resolution 3.60 Å |