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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q00604 New Search
12PDB entries
16Biological assembly
30chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4MY2 Crystal Structure of Norrin in fusion with Maltose Binding Protein Deposited 2013-09-27 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–104（104 aa） Fragment：Maltose binding protein (UNP residues 26-392), Norrin (UNP residues 30-133) fusion protein
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；15% PEG 3350, 0.1 M sodium acetate, pH 4.6, 0.2 M ammonium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.40 Å R-free 0.237
5BPU Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I Deposited 2015-05-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 25–133（109 aa） Fragment：residues 25-133
Chain B 25–133（109 aa） Fragment：residues 25-133
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M sodium acetate, pH 5.0, 5% PGA-LM, 30% PEG550MME
Resolution 2.40 Å R-free 0.263
5BPU Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I Deposited 2015-05-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 25–133（109 aa） Fragment：residues 25-133
Chain D 25–133（109 aa） Fragment：residues 25-133
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M sodium acetate, pH 5.0, 5% PGA-LM, 30% PEG550MME
Resolution 2.40 Å R-free 0.263
5BPU Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I Deposited 2015-05-28 Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 25–133（109 aa） Fragment：residues 25-133
Chain F 25–133（109 aa） Fragment：residues 25-133
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M sodium acetate, pH 5.0, 5% PGA-LM, 30% PEG550MME
Resolution 2.40 Å R-free 0.263
5BQ8 Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II Deposited 2015-05-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 25–133（109 aa） Fragment：UNP residues 25-133
Chain B 25–133（109 aa） Fragment：UNP residues 25-133
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 sodium acetate, pH 5.0, 5% PGA-LM, 4% PEG2000MME, 24% PEG550MME
Resolution 2.00 Å R-free 0.248
5BQ8 Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II Deposited 2015-05-28 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 25–133（109 aa） Fragment：UNP residues 25-133
Chain D 25–133（109 aa） Fragment：UNP residues 25-133
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 sodium acetate, pH 5.0, 5% PGA-LM, 4% PEG2000MME, 24% PEG550MME
Resolution 2.00 Å R-free 0.248
5BQB Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III Deposited 2015-05-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 25–133（109 aa） Fragment：residues 25-133
Chain B 25–133（109 aa） Fragment：residues 25-133
Not recorded CIT CITRIC ACID × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1M citrate, pH 5.0, 30% PEG6000
Resolution 2.30 Å R-free 0.251
5BQB Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III Deposited 2015-05-28 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 25–133（109 aa） Fragment：residues 25-133
Chain D 25–133（109 aa） Fragment：residues 25-133
Not recorded CIT CITRIC ACID × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1M citrate, pH 5.0, 30% PEG6000
Resolution 2.30 Å R-free 0.251
5BQC Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and sucrose octasulfate Deposited 2015-05-28 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 25–133（109 aa） Fragment：residues 25-133
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M Tris, pH 8.0, 0.15 M NaCl, 8% PEG8000
Resolution 3.00 Å R-free 0.268
5BQE Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 -Methylated form Deposited 2015-05-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 25–133（109 aa） Fragment：residues 25-133
Chain B 25–133（109 aa） Fragment：residues 25-133
Non-standard monomer：Yes (specific site not provided by mmCIF) PG0 2-(2-METHOXYETHOXY)ETHANOL × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M Bicine, pH 9.0, 10% PEG6000
Resolution 2.30 Å R-free 0.221
5CL1 Complex structure of Norrin with human Frizzled 4 Deposited 2015-07-16 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 31–133（103 aa） Fragment：UNP Q00604 residues 31-133
Chain B 31–133（103 aa） Fragment：UNP Q00604 residues 31-133
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；200 mM ammonium sulfate, 100 mM sodium cacodylate trihydrate (pH 6.5), 15% w/v polyethylene glycol 8,000
Resolution 3.80 Å R-free 0.310
8WVX Cryo-EM structure of LGR4 in complex with Norrin(dimer) Deposited 2023-10-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 31–133（103 aa）
Chain D 31–133（103 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen PROPANE
Resolution 3.32 Å
8WVY Cryo-EM structure of LGR4 in complex with Norrin Deposited 2023-10-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 31–133（103 aa）
Chain F 31–133（103 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen PROPANE
Resolution 3.29 Å
9KHH Structure of the complex of LGR4 with Norrin (2:2) Deposited 2024-11-10 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain E 25–133（109 aa）
Chain F 25–133（109 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.65 Å
9MAN Structure of Norrin in complex with human Tspan12 large extracellular loop (Tspan12 LEL) Deposited 2025-03-14 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 25–133（109 aa）
Chain B 25–133（109 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.78 Å
9UOK Structure of the complex of LGR4_ECD with Norrin Deposited 2025-04-25 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain E 25–133（109 aa）
Chain F 25–133（109 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.05 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.