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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q08209 New Search
21PDB entries
26Biological assembly
35chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1AUI HUMAN CALCINEURIN HETERODIMER Deposited 1997-08-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–521（521 aa）
Not recorded ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；PROTEIN WAS CRYSTALLIZED FROM 8% PEG 6000, 0.1M CACL2, 0.1M TES PH 7.5, 1 MM DTT.
Resolution 2.10 Å
1M63 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes Deposited 2002-07-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–372（372 aa） Fragment：RESIDUES 1-372
Chain E 1–372（372 aa） Fragment：RESIDUES 1-372
Not recorded ZN ZINC ION × 2 FE FE (III) ION × 2 CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；0.1 M NA CACODYLATE, 0.2 M MGCL2, 13% PEG8000, 2.5% ETHANOL, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 295K
Resolution 2.80 Å R-free 0.322
1MF8 Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin Deposited 2002-08-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 20–392（373 aa） Fragment：TRUNCATED FORM (RESIDUES 20-392)
Not recorded PO4 PHOSPHATE ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.6；12% PEG 4000, 5MM POTASSIUM PHOSPHATE, 75MM SODIUM CITRATE, 15% GLYCEROL, 5MM TRIS, PH 4.6, MICROBATCH, TEMPERATURE 292K
Resolution 3.10 Å R-free 0.300
2JOG Structure of the calcineurin-NFAT complex Deposited 2007-03-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 21–347（327 aa） Fragment：residues 21-347
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；298 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient
NMR sample composition 500uM [U-13C; U-15N; U-2H] calcineurin, 0.4-0.6 mM NFAT, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 300uM calcineurin, 0.3 mM [U-13C; U-15N; U-2H] NFAT, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 400uM [2H, FIMY-1H] calcineurin, 0.4 mM [ul-2H15N, Id1LdVg -1H13C] NFAT, 100% D2O | 100% D2O
Resolution not provided
2JZI Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin Deposited 2008-01-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 391–414（24 aa） Fragment：UNP residues 391-414, Calmodulin_binding_domain_of_Calcineurin
Not recorded CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 6.5；310 K
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] Calmodulin, 1 mM [U-99% 13C; U-99% 15N] Calmodulin binding domain of Calcineurin, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2P6B Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide Deposited 2007-03-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 1–380（380 aa） Fragment：Residues 1-381
Chain C 1–380（380 aa） Fragment：Residues 1-381
Not recorded ZN ZINC ION × 2 FE FE (III) ION × 2 PO4 PHOSPHATE ION × 2 CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；12% PEG 4000, 0.1M calcium chloride, 0.1M TES, 0.001M DTT, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.30 Å R-free 0.254
2R28 The complex Structure of Calmodulin Bound to a Calcineurin Peptide Deposited 2007-08-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 389–413（25 aa）
Chain D 389–413（25 aa）
Not recorded CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；20% PEG 3350, 0.2M ammonium phosphate, 0.1M citrite acid , pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 1.86 Å R-free 0.280
2W73 High-resolution structure of the complex between calmodulin and a peptide from calcineurin A Deposited 2008-12-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain K 395–411（17 aa） Fragment：CALMODULIN BINDING DOMAIN, RESIDUES 385-411
Chain L 395–411（17 aa） Fragment：CALMODULIN BINDING DOMAIN, RESIDUES 385-411
Not recorded CA CALCIUM ION × 11 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.45 Å R-free 0.217
2W73 High-resolution structure of the complex between calmodulin and a peptide from calcineurin A Deposited 2008-12-19 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain M 395–411（17 aa） Fragment：CALMODULIN BINDING DOMAIN, RESIDUES 385-411
Chain O 395–411（17 aa） Fragment：CALMODULIN BINDING DOMAIN, RESIDUES 385-411
Not recorded CA CALCIUM ION × 9 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.45 Å R-free 0.217
3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 14–370（357 aa） Fragment：UNP residues 14-370
Not recorded PO4 PHOSPHATE ION × 1 ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000 MgSO4 CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.228
3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 14–370（357 aa） Fragment：UNP residues 14-370
Not recorded PO4 PHOSPHATE ION × 1 ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000 MgSO4 CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.228
3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 Assembly 3 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 14–370（357 aa） Fragment：UNP residues 14-370
Chain C 14–370（357 aa） Fragment：UNP residues 14-370
Not recorded PO4 PHOSPHATE ION × 2 ZN ZINC ION × 2 FE FE (III) ION × 2 CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000 MgSO4 CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.228
4F0Z Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L Deposited 2012-05-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa） Fragment：Calcineurin A Subunit
Not recorded GOL GLYCEROL × 8 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；295 K；0.16 M ammonium citrate dibasic, 20% (w/v) PEG3350, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 1.70 Å R-free 0.178
4Q5U Structure of calmodulin bound to its recognition site from calcineurin Deposited 2014-04-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 391–414（24 aa） Fragment：calmodulin-binding domain (UNP residues 391-414)
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3:1 10 mg/ml protein to mother liquor (24% PEG1000, 20% glycerol), final volume 200 nL, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 1.95 Å R-free 0.248
5C1V CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN Deposited 2015-06-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–346（345 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 2-347
Mutation：YES FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；0.1 M HEPES, 25% PEG 3350, PH 7.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
Resolution 3.35 Å R-free 0.249
5C1V CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN Deposited 2015-06-15 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 2–346（345 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 2-347
Mutation：YES FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；0.1 M HEPES, 25% PEG 3350, PH 7.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
Resolution 3.35 Å R-free 0.249
5SVE Structure of Calcineurin in complex with NFATc1 LxVP peptide Deposited 2016-08-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Not recorded FE FE (III) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1 M HEPES pH 7.0 15% Peg 4000
Resolution 2.60 Å R-free 0.239
6NUC Structure of Calcineurin in complex with NHE1 peptide Deposited 2019-01-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Not recorded FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9.5；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
Resolution 1.90 Å R-free 0.194
6NUF Structure of Calcineurin in complex with NHE1 peptide Deposited 2019-01-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Not recorded FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PGE TRIETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
Resolution 1.90 Å R-free 0.209
6NUU Structure of Calcineurin mutant in complex with NHE1 peptide Deposited 2019-02-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Mutation：H155A, Y159A FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9.5；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
Resolution 2.30 Å R-free 0.243
6UUQ Structure of Calcineurin bound to RCAN1 Deposited 2019-10-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 26–339（314 aa）
Not recorded PO4 PHOSPHATE ION × 2 ZN ZINC ION × 1 FE FE (III) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；0.1 M Sodium cacodylate, 12% Peg 8000, 0.1 M Calcium acetate
Resolution 1.85 Å R-free 0.205
9B9G Structure of the PI4KA complex bound to Calcineurin Deposited 2024-04-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain I 2–391（390 aa）
Chain I 162–391（230 aa）
Chain K 2–391（390 aa）
Chain K 162–391（230 aa）
Mutation：L236P,D238N Mutation：L236P,D238N Mutation：L236P,D238N Mutation：L236P,D238N CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；Freshly prepared gel filtration buffer, filtered through 0.22um filter and degassed
cryo-EM vitrification conditions Cryogen ETHANE；Blot force -5, blot time 1 s
Resolution 3.50 Å
9NXE Crystal Structure of Calcineurin Clinical Variant E282K Deposited 2025-03-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Mutation：E282K PEG DI(HYDROXYETHYL)ETHER × 1 FE FE (III) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；290 K；0.1 M CAPS pH 9, 0.2 M MgCl2 and 24% PEG 600
Resolution 2.09 Å R-free 0.243
9NXF Crystal structure of CN:Tak1 complex Deposited 2025-03-25 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Mutation：D90A FE FE (III) ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；200 mM Sodium citrate tribasic pH 8.4, 22% PEG 3350, 3% ethanol. Microseeding
Resolution 3.13 Å R-free 0.295
9NXF Crystal structure of CN:Tak1 complex Deposited 2025-03-25 Assembly 2 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 1–370（370 aa）
Mutation：D90A FE FE (III) ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CA CALCIUM ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；200 mM Sodium citrate tribasic pH 8.4, 22% PEG 3350, 3% ethanol. Microseeding
Resolution 3.13 Å R-free 0.295
9NXN Crystal structure of CN:RII alpha Deposited 2025-03-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–370（370 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；289 K；0.1 M sodium citrate pH 5.0, 0.1 M Magnesium chloride hexahydrate, 15% PEG 4000
Resolution 2.10 Å R-free 0.250

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.