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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q12809 New Search
21PDB entries
27Biological assembly
104chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BYW STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN-ERG POTASSIUM CHANNEL Deposited 1998-10-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 26–135（110 aa） Fragment：N-TERMINAL DOMAIN
Mutation：R73C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；PROTEIN SOLUTION AT 10MG/ML IN 10MM DTT, 5 MM N-OCTYL-GLUCO MIXED WITH EQUAL VOLUME OF 100 MM HEPES PH 7.0, 0.8-1.0 M SODIUM AND POTASSIUM TARTRAT
Resolution 2.60 Å R-free 0.286
1UJL Solution Structure of the HERG K+ channel S5-P extracellular linker Deposited 2003-08-05 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 570–611（42 aa） Fragment：RESIDUES 1-42
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 3.3；303 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 1.4mM S5-P peptide | 100mM SDS, 90% H2O, 10% D2O
Resolution not provided
2L1M Solution structure of the eag domain of the hERG (Kv11.1) K+ channel Deposited 2010-07-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–135（135 aa） Fragment：UNP residues 1-135
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure ambient
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] protein, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.4 mM [U-100% 15N] protein, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2L4R NMR solution structure of the N-terminal PAS domain of hERG Deposited 2010-10-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–135（135 aa） Fragment：UNP RESIDUES 1-135
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 150；Pressure AMBIENT
NMR sample composition 0.5-1 mM [U-99% 13C; U-99% 15N] entity-1, 5 mM DTT-2, 1 mM EDTA-3, 150 mM sodium chloride-4, 20 mM sodium phosphate-5, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2LE7 Solution nmr structure of the S4S5 linker of herg potassium channel Deposited 2011-06-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 532–551（20 aa） Fragment：residues 532-551
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.6；300 K；Pressure AMBIENT
NMR sample composition 100mM DPC-1, 90%(v/v) H2O-2, 10%(v/v) [U-2H] D2O-3, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2N7G Structure of the cyclic nucleotide-binding homology domain of the hERG channel Deposited 2015-09-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 734–864（131 aa） Fragment：UNP residues 734-869
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.2；298 K；Ionic strength (raw mmCIF value) 170；Pressure ambient
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] the cyclic nucleotide-binding homology domain of the hERG channel-1, 20 mM sodium phosphate-2, 150 mM sodium chloride-3, 1 mM DTT-4, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
4HP9 Crystal structure of the N-terminal truncated PAS domain from the hERG potassium channel Deposited 2012-10-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 10–135（126 aa） Fragment：PAS domain of KCNH channel, UNP residues 10-135
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；30% PEG-MME2000, 0.1M potasiumm thiocyanate, 1.0% benzamidine-HCl, vapor diffusion, sitting drop, temperature 298K
Resolution 2.12 Å R-free 0.238
4HQA Crystal structure of PAS domain from the human ERG (hERG) potassium channel Deposited 2012-10-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–135（135 aa） Fragment：PAS domain of KCNH channel, UNP residues 1-135
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；1.0M sodium/potassium tartrate, 0.1M Hepes, pH 7.0, vapor diffusion, sitting drop, temperature 298K
Resolution 1.96 Å R-free 0.239
5VA1 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.70 Å
5VA1 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.70 Å
5VA1 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.70 Å
5VA2 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 351–870（520 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.80 Å
5VA2 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 351–870（520 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.80 Å
5VA2 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 351–870（520 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 3.80 Å
5VA3 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Mutation：S631A Mutation：S631A Mutation：S631A No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 4.00 Å
5VA3 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Mutation：S631A Mutation：S631A Mutation：S631A No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 4.00 Å
5VA3 Cryo-EM structure of the human ether-a-go-go related K+ channel Deposited 2017-03-24 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–140（140 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 381–870（490 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Chain A 1006–1159（154 aa） Fragment：UNP residues 1-140,381-870,1006-1159
Mutation：S631A Mutation：S631A Mutation：S631A No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4, adjusted with NaOH
cryo-EM vitrification conditions Cryogen ETHANE；one blot: 3 second blot time, 0 blot force
Resolution 4.00 Å
6SYG Crystal structure of the Cyclic Nucleotide-Binding Homology Domain of the human KCNH2 channel Deposited 2019-09-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 734–864（131 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；20% w/v PEG 3350, 2% v/v Tacsimate, 0.1M Bis-Tris, pH 6.8
Resolution 1.50 Å R-free 0.184
8IO4 Herg1a-herg1b open state Deposited 2023-03-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1159（1159 aa）
Chain B 1–1159（1159 aa）
Chain C 1–1159（1159 aa）
Chain D 1–1159（1159 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8ZYN Cryo-EM Structure of inhibitor-free hERG Channel Deposited 2024-06-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa）
Chain A 351–870（520 aa）
Chain A 1006–1159（154 aa）
Chain B 1–140（140 aa）
Chain B 351–870（520 aa）
Chain B 1006–1159（154 aa）
Chain C 1–140（140 aa）
Chain C 351–870（520 aa）
Chain C 1006–1159（154 aa）
Chain D 1–140（140 aa）
Chain D 351–870（520 aa）
Chain D 1006–1159（154 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å
8ZYO Cryo-EM Structure of astemizole-bound hERG Channel Deposited 2024-06-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa）
Chain A 351–870（520 aa）
Chain A 1006–1159（154 aa）
Chain B 1–140（140 aa）
Chain B 351–870（520 aa）
Chain B 1006–1159（154 aa）
Chain C 1–140（140 aa）
Chain C 351–870（520 aa）
Chain C 1006–1159（154 aa）
Chain D 1–140（140 aa）
Chain D 351–870（520 aa）
Chain D 1006–1159（154 aa）
Not recorded XB7 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.29 Å
8ZYP Cryo-EM Structure of E-4031-bound hERG Channel Deposited 2024-06-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa）
Chain A 351–870（520 aa）
Chain A 1006–1159（154 aa）
Chain B 1–140（140 aa）
Chain B 351–870（520 aa）
Chain B 1006–1159（154 aa）
Chain C 1–140（140 aa）
Chain C 351–870（520 aa）
Chain C 1006–1159（154 aa）
Chain D 1–140（140 aa）
Chain D 351–870（520 aa）
Chain D 1006–1159（154 aa）
Not recorded A1L2J ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.19 Å
8ZYQ Cryo-EM Structure of pimozide-bound hERG Channel Deposited 2024-06-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–140（140 aa）
Chain A 351–870（520 aa）
Chain A 1006–1159（154 aa）
Chain B 1–140（140 aa）
Chain B 351–870（520 aa）
Chain B 1006–1159（154 aa）
Chain C 1–140（140 aa）
Chain C 351–870（520 aa）
Chain C 1006–1159（154 aa）
Chain D 1–140（140 aa）
Chain D 351–870（520 aa）
Chain D 1006–1159（154 aa）
Not recorded 1II 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
9CHP Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ Deposited 2024-07-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1159（1159 aa）
Chain B 1–1159（1159 aa）
Chain C 1–1159（1159 aa）
Chain D 1–1159（1159 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9CHQ Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+ Deposited 2024-07-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1159（1159 aa）
Chain B 1–1159（1159 aa）
Chain C 1–1159（1159 aa）
Chain D 1–1159（1159 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9CHR Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry Deposited 2024-07-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1159（1159 aa）
Chain B 1–1159（1159 aa）
Chain C 1–1159（1159 aa）
Chain D 1–1159（1159 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9CHS Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+ without symmetry Deposited 2024-07-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1159（1159 aa）
Chain B 1–1159（1159 aa）
Chain C 1–1159（1159 aa）
Chain D 1–1159（1159 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.