Current Protein Identity：Q15418
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2WNT Crystal Structure of the Human Ribosomal protein S6 kinase Deposited 2009-07-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
413–719（307 aa）
Fragment：RESIDUES 413-719
Chain B
413–719（307 aa）
Fragment：RESIDUES 413-719
|
Not recorded | NA SODIUM ION × 3 CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20% PEG 3350, 0.20M NA(FORM)
|
Resolution 2.40 Å R-free 0.240 |
| 2Z7Q Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP Deposited 2007-08-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
33–353（321 aa）
Fragment：Residues 33-353
|
Not recorded | MG MAGNESIUM ION × 1 ACP PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；12-16% PEG MME 2000, 150mM DL-malic acid, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.283 |
| 2Z7R Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine Deposited 2007-08-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
33–353（321 aa）
Fragment：Residues 33-353
|
Not recorded | STU STAUROSPORINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；12-16% PEG MME 2000, 150mM DL-malic acid, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.286 |
| 2Z7S Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A Deposited 2007-08-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
33–353（321 aa）
Fragment：Residues 33-353
|
Not recorded | P01 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；12-16% PEG MME 2000, 150mM DL-malic acid , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å |
| 3RNY Crystal structure of human RSK1 C-terminal kinase domain Deposited 2011-04-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
411–735（325 aa）
Fragment：UNP residues 411-735
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1 M HEPES pH 7.5, 17.1%(w/v) PEG 3350, 4%(v/v) acetonitrile or 18%(w/v)
PEG 3350, 100 mM ammonium formate, 4%(v/v) acetonitrile, vapor diffusion, sitting drop, temperature 290K
|
Resolution 2.70 Å R-free 0.238 |
| 3RNY Crystal structure of human RSK1 C-terminal kinase domain Deposited 2011-04-24 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
411–735（325 aa）
Fragment：UNP residues 411-735
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1 M HEPES pH 7.5, 17.1%(w/v) PEG 3350, 4%(v/v) acetonitrile or 18%(w/v)
PEG 3350, 100 mM ammonium formate, 4%(v/v) acetonitrile, vapor diffusion, sitting drop, temperature 290K
|
Resolution 2.70 Å R-free 0.238 |
| 3RNY Crystal structure of human RSK1 C-terminal kinase domain Deposited 2011-04-24 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
411–735（325 aa）
Fragment：UNP residues 411-735
Chain B
411–735（325 aa）
Fragment：UNP residues 411-735
|
Not recorded | NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1 M HEPES pH 7.5, 17.1%(w/v) PEG 3350, 4%(v/v) acetonitrile or 18%(w/v)
PEG 3350, 100 mM ammonium formate, 4%(v/v) acetonitrile, vapor diffusion, sitting drop, temperature 290K
|
Resolution 2.70 Å R-free 0.238 |
| 3TEI Crystal structure of human ERK2 complexed with a MAPK docking peptide Deposited 2011-08-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
712–735（24 aa）
Fragment：C-TERMINAL DOCKING PEPTIDE, RESIDUES 712-735
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；296 K；27-29% PEG 6000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 2.40 Å R-free 0.235 |
| 4H3P Crystal structure of human ERK2 complexed with a MAPK docking peptide Deposited 2012-09-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
712–735（24 aa）
Fragment：C-TERMINAL DOCKING PEPTIDE, UNP residues 712-735
|
Mutation：S719A, Q724A | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；25-30% PEG6000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 2.30 Å R-free 0.224 |
| 4H3P Crystal structure of human ERK2 complexed with a MAPK docking peptide Deposited 2012-09-14 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
712–735（24 aa）
Fragment：C-TERMINAL DOCKING PEPTIDE, UNP residues 712-735
|
Mutation：S719A, Q724A | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；25-30% PEG6000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 2.30 Å R-free 0.224 |
| 4NIF Heterodimeric structure of ERK2 and RSK1 Deposited 2013-11-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
411–735（325 aa）
Fragment：C-terminal kinase domain, UNP residues 411-735
Chain D
411–735（325 aa）
Fragment：C-terminal kinase domain, UNP residues 411-735
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 SO4 SULFATE ION × 3 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.25；296 K；0.1M MES, 15% PEG4000, 0.125M (NH4)2SO4, 2% Benzamidine, pH 6.25, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
Resolution 2.15 Å R-free 0.208 |
| 5CSF S100B-RSK1 crystal structure A Deposited 2015-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
683–735（53 aa）
Fragment：UNP residues 683-735
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1 M Hepes 7, 150 mM NaCl, 20% PEG6000
|
Resolution 2.40 Å R-free 0.291 |
| 5CSI S100B-RSK1 crystal structure A' Deposited 2015-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
689–735（47 aa）
Fragment：UNP residues 689-735
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1 M Hepes 7, 150 mM NaCl, 20% PEG6000
|
Resolution 2.13 Å R-free 0.250 |
| 5CSJ S100B-RSK1 crystal structure B Deposited 2015-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
696–735（40 aa）
Fragment：UNP residues 696-735
|
Not recorded | CA CALCIUM ION × 4 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1 M Hepes 7, 150 mM NaCl, 20% PEG6000
|
Resolution 2.70 Å R-free 0.276 |
| 5CSN S100B-RSK1 crystal structure C Deposited 2015-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
683–720（38 aa）
Fragment：UNP residues 683-720
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1 M Hepes 7, 150 mM NaCl, 20% PEG6000
|
Resolution 2.95 Å R-free 0.279 |
| 5N7D MAGI-1 complexed with a RSK1 peptide Deposited 2017-02-20 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
697–744（48 aa）
|
Not recorded | GOL GLYCEROL × 3 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；296 K；8% PEG 400, 100 mM acetate buffer
|
Resolution 2.30 Å R-free 0.227 |
| 5N7F MAGI-1 complexed with a pRSK1 peptide Deposited 2017-02-20 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
688–735（48 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 3 CA CALCIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
|
Resolution 2.30 Å R-free 0.240 |
| 5N7G MAGI-1 complexed with a synthetic pRSK1 peptide Deposited 2017-02-20 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
729–735（7 aa）
Fragment：UNP residues 88-94
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 3 CA CALCIUM ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
|
Resolution 2.95 Å R-free 0.264 |
| 5V61 Phospho-ERK2 bound to bivalent inhibitor SBP2 Deposited 2017-03-15 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain I
713–729（17 aa）
Fragment：UNP Q15418 residues 713-729, UNP P04608 residues 730-738
|
Not recorded | GOL GLYCEROL × 3 FRZ 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE × 1 90A 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.1 M Bis-Tris pH 6.5, 45% v/v polypropylene glycol P400
|
Resolution 2.20 Å R-free 0.212 |
| 5V62 Phospho-ERK2 bound to bivalent inhibitor SBP3 Deposited 2017-03-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain I
713–729（17 aa）
Fragment：UNP residues 713-729
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 5 FRZ 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE × 1 AKS N-(hex-5-yn-1-yl)hexanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；0.1 M Tris-Bicine pH 8.5, 0.02 M each of 1,6-Hexanediol, 1-Butanol, 1,2-Propanediol, 2-Propanol, 1,4-Butanediol, 1,3-Propanediol, 20% v/v PEG550MME, 10% w/v PEG20,000
|
Resolution 1.90 Å R-free 0.203 |
| 7P74 The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2021-07-19 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
725–735（11 aa）
|
Mutation：N-terminal biotin-ttds label Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 4 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100mM ammonium sulfate, 100mM sodium formate, 25% PEG smear broad
|
Resolution 1.90 Å R-free 0.211 |
| 7PC8 The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ-binding motif of RSK1 Deposited 2021-08-03 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
726–735（10 aa）
|
Not recorded | CA CALCIUM ION × 5 GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.15 M Lithium sulfate, 0.05 M Magnesium chloride hexahydrate ,0.1 M HEPES 7.8, 20 % v/v PEG Smear High
|
Resolution 2.50 Å R-free 0.232 |
| 7PC8 The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ-binding motif of RSK1 Deposited 2021-08-03 | Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
726–735（10 aa）
|
Not recorded | CA CALCIUM ION × 4 GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.15 M Lithium sulfate, 0.05 M Magnesium chloride hexahydrate ,0.1 M HEPES 7.8, 20 % v/v PEG Smear High
|
Resolution 2.50 Å R-free 0.232 |
| 7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
725–735（11 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 5 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
|
Resolution 2.44 Å R-free 0.230 |
| 7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 | Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
725–735（11 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 4 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
|
Resolution 2.44 Å R-free 0.230 |
| 7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 | Assembly 3 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
725–735（11 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 5 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
|
Resolution 2.44 Å R-free 0.230 |
| 8WF4 The Crystal Structure of RSK1 from Biortus. Deposited 2023-09-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
411–735（325 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1M Hepes pH7.0, 15% PEG 20000
|
Resolution 2.65 Å R-free 0.309 |
| 8WF4 The Crystal Structure of RSK1 from Biortus. Deposited 2023-09-19 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
411–735（325 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1M Hepes pH7.0, 15% PEG 20000
|
Resolution 2.65 Å R-free 0.309 |
| 8XOV The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. Deposited 2024-01-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
33–353（321 aa）
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1M MgAC2, 0.1M Nacacodylate pH6.5, 15% PEG 6000
|
Resolution 2.55 Å R-free 0.252 |