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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q16630 New Search
14PDB entries
25Biological assembly
56chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3P5T CFIm25-CFIm68 complex Deposited 2010-10-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain L 80–161（82 aa） Fragment：UNP residues 80-161
Chain M 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；283 K；16% PEG 3350, 5% dioxane, 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 283K
Resolution 2.70 Å R-free 0.265
3P5T CFIm25-CFIm68 complex Deposited 2010-10-11 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain N 80–161（82 aa） Fragment：UNP residues 80-161
Chain O 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；283 K；16% PEG 3350, 5% dioxane, 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 283K
Resolution 2.70 Å R-free 0.265
3P5T CFIm25-CFIm68 complex Deposited 2010-10-11 Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain P 80–161（82 aa） Fragment：UNP residues 80-161
Chain Q 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；283 K；16% PEG 3350, 5% dioxane, 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 283K
Resolution 2.70 Å R-free 0.265
3P6Y CF Im25-CF Im68-UGUAA complex Deposited 2010-10-11 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 80–161（82 aa） Fragment：UNP residues 80-161
Chain D 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；283 K；15% PEG 3350, 9% dioxane and 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 283K
Resolution 2.90 Å R-free 0.275
3P6Y CF Im25-CF Im68-UGUAA complex Deposited 2010-10-11 Assembly 2 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain G 80–161（82 aa） Fragment：UNP residues 80-161
Chain H 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；283 K；15% PEG 3350, 9% dioxane and 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 283K
Resolution 2.90 Å R-free 0.275
3P6Y CF Im25-CF Im68-UGUAA complex Deposited 2010-10-11 Assembly 3 Protein–RNA Heteromer；Protein × 4 PDB declaration: pentameric（5） Consistent with all polymers
Chain K 80–161（82 aa） Fragment：UNP residues 80-161
Chain L 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；283 K；15% PEG 3350, 9% dioxane and 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 283K
Resolution 2.90 Å R-free 0.275
3P6Y CF Im25-CF Im68-UGUAA complex Deposited 2010-10-11 Assembly 4 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain O 80–161（82 aa） Fragment：UNP residues 80-161
Chain P 80–161（82 aa） Fragment：UNP residues 80-161
Mutation：C159S Mutation：C159S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；283 K；15% PEG 3350, 9% dioxane and 0.1M sodium citrate, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 283K
Resolution 2.90 Å R-free 0.275
3Q2S Crystal Structure of CFIm68 RRM/CFIm25 complex Deposited 2010-12-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 13–235（223 aa） Fragment：RRM domain, residues 13-235
Chain D 13–235（223 aa） Fragment：RRM domain, residues 13-235
Mutation：C159V Mutation：C159V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；20% PEG 3350, 0.2M Magnesium Formate, 0.05M HEPES pH 7.0, vapor diffusion, hanging drop, temperature 298K
Resolution 2.90 Å R-free 0.278
3Q2T Crystal Structure of CFIm68 RRM/CFIm25/RNA complex Deposited 2010-12-20 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 13–235（223 aa） Fragment：RRM domain, residues 13-235
Chain D 13–235（223 aa） Fragment：RRM domain, residues 13-235
Mutation：C159V Mutation：C159V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；20% PEG 3350, 0.2M Magnesium Formate, 0.05M HEPES pH 7.0, vapor diffusion, hanging drop, temperature 298K
Resolution 3.06 Å R-free 0.286
4B4N CPSF6 defines a conserved capsid interface that modulates HIV-1 replication Deposited 2012-07-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 313–327（15 aa） Fragment：RESIDUES 313-327
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；290 K；17 DEGREES (SITTING DROPS).PROTEIN/ PEPTIDE SOLUTION (0.37 MM HIV-1 CAN AND 4 MM CPSF6313-327 IN 20 MM HEPES PH 7, 50 MM NACL, 1 MM DTT) WAS MIXED WITH RESERVOIR SOLUTION (20% W/V PEG 3350, 0.2 M POTASSIUM PHOSPHATE DIBASIC) IN A 1:1 MIX.
Resolution 1.81 Å R-free 0.273
4U0A Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form Deposited 2014-07-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: Dodecameric（12） Consistent with protein count
Chain B 276–290（15 aa） Fragment：UNP residues 313-327
Not recorded CL CHLORIDE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；0.6M sodium potassium tartrate tetrahydrate, 0.1M TRIS
Resolution 2.05 Å R-free 0.253
4U0B Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form Deposited 2014-07-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: Dodecameric（12） Consistent with protein count
Chain M 276–290（15 aa） Fragment：UNP residues 276-290
Chain N 276–290（15 aa） Fragment：UNP residues 276-290
Chain O 276–290（15 aa） Fragment：UNP residues 276-290
Chain P 276–290（15 aa） Fragment：UNP residues 276-290
Chain Q 276–290（15 aa） Fragment：UNP residues 276-290
Chain R 276–290（15 aa） Fragment：UNP residues 276-290
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；20% v/v PEG 300, 10% v/v glycerol, 5% w/v PEG 8K, 0.1 M TRIS
Resolution 2.80 Å R-free 0.262
4U0B Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form Deposited 2014-07-11 Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: Dodecameric（12） Consistent with protein count
Chain S 276–290（15 aa） Fragment：UNP residues 276-290
Chain T 276–290（15 aa） Fragment：UNP residues 276-290
Chain U 276–290（15 aa） Fragment：UNP residues 276-290
Chain V 276–290（15 aa） Fragment：UNP residues 276-290
Chain W 276–290（15 aa） Fragment：UNP residues 276-290
Chain X 276–290（15 aa） Fragment：UNP residues 276-290
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；20% v/v PEG 300, 10% v/v glycerol, 5% w/v PEG 8K, 0.1 M TRIS
Resolution 2.80 Å R-free 0.262
4WYM Structural basis of HIV-1 capsid recognition by CPSF6 Deposited 2014-11-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain M 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain N 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain O 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain P 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain Q 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain R 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M sodium formate, ammonium acetate, tri-sodium citrate, sodium/potassium tartrate, sodium oxamate; 0.1 M sodium HEPES, MOPS; 30% glycerol, PEG 4000
Resolution 2.60 Å R-free 0.259
4WYM Structural basis of HIV-1 capsid recognition by CPSF6 Deposited 2014-11-17 Assembly 2 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain S 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain T 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain U 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain V 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Chain W 313–327（15 aa） Fragment：UNP RESIDUES 313-327
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M sodium formate, ammonium acetate, tri-sodium citrate, sodium/potassium tartrate, sodium oxamate; 0.1 M sodium HEPES, MOPS; 30% glycerol, PEG 4000
Resolution 2.60 Å R-free 0.259
6AY9 Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide Deposited 2017-09-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 276–287（12 aa） Fragment：UNP residues 276-287
Not recorded IOD IODIDE ION × 36 CL CHLORIDE ION × 24 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；PEG3350, NaI, Sodium cacodylate, Glycerol
Resolution 2.50 Å R-free 0.273
6GX9 Crystal structure of the TNPO3 - CPSF6 RSLD complex Deposited 2018-06-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 408–477（70 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 2 BCN BICINE × 1 BEN BENZAMIDINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；12.8% PEG MME 500, 6.4% PEG 20,000, 4% 1,6-hexandiol, 1.5% benzamidine, 75 mM NaCl, 40 mM MgCl2, 6 mM DTT, 80 mM Tris-bicine, pH 8.0
Resolution 2.70 Å R-free 0.248
6GX9 Crystal structure of the TNPO3 - CPSF6 RSLD complex Deposited 2018-06-26 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 408–477（70 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 2 BCN BICINE × 1 BEN BENZAMIDINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；12.8% PEG MME 500, 6.4% PEG 20,000, 4% 1,6-hexandiol, 1.5% benzamidine, 75 mM NaCl, 40 mM MgCl2, 6 mM DTT, 80 mM Tris-bicine, pH 8.0
Resolution 2.70 Å R-free 0.248
7ZUD Crystal structure of HIV-1 capsid IP6-CPSF6 complex Deposited 2022-05-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain M 276–288（13 aa）
Not recorded IHP INOSITOL HEXAKISPHOSPHATE × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.3M Calcium chloride dihydrate, 0.3 M Magnesium chloride hexahydrate, 0.1 M Tris hydrochloride pH 8.5, 0.1 M Bicine, 20% PEG 4000
Resolution 2.93 Å R-free 0.336
8CL1 HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to CPSF6 peptide. Deposited 2023-02-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 276–290（15 aa） Fragment：UNP residues 313-327
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.1
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.35 Å
8EJL Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide Deposited 2022-09-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric（30） Consistent with protein count
Chain Y 313–327（15 aa） Fragment：UNP residues 313-327
Chain Z 313–327（15 aa） Fragment：UNP residues 313-327
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE；Manual plunge-freezing
Resolution 3.90 Å
8EJL Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide Deposited 2022-09-17 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain Y 313–327（15 aa） Fragment：UNP residues 313-327
Chain Z 313–327（15 aa） Fragment：UNP residues 313-327
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE；Manual plunge-freezing
Resolution 3.90 Å
8EJL Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide Deposited 2022-09-17 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain Y 313–327（15 aa） Fragment：UNP residues 313-327
Chain Z 313–327（15 aa） Fragment：UNP residues 313-327
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE；Manual plunge-freezing
Resolution 3.90 Å
9CNV HIV-2 CA hexamer bound with CPSF6 peptide; assembled via liposome templating Deposited 2024-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 313–327（15 aa）
Mutation：Delta(1-312) and Delta(328-358) IHP INOSITOL HEXAKISPHOSPHATE × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；The mixed buffer of storage buffer for the protein and lipid components with IP6 supplemented.
cryo-EM vitrification conditions Cryogen ETHANE；Grids were dual-side blotted with blot force 0 for 5.5 sec before plunge freezing in liquid ethane.
Resolution 3.16 Å
9CNV HIV-2 CA hexamer bound with CPSF6 peptide; assembled via liposome templating Deposited 2024-07-15 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 313–327（15 aa）
Mutation：Delta(1-312) and Delta(328-358) IHP INOSITOL HEXAKISPHOSPHATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；The mixed buffer of storage buffer for the protein and lipid components with IP6 supplemented.
cryo-EM vitrification conditions Cryogen ETHANE；Grids were dual-side blotted with blot force 0 for 5.5 sec before plunge freezing in liquid ethane.
Resolution 3.16 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.