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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q5F4S7 New Search
15PDB entries
15Biological assembly
57chain/assembly records
Main Difference Dimensions in This Set
Different construct Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6RMV The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer Deposited 2019-05-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 592–606（15 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291.15 K；0.1 M HEPES sodium pH 7.5, 15% (w/v) polyethylene glycol 4,000, 7.5% (v/v) isopropanol
Resolution 1.94 Å R-free 0.224
8DDQ cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel Deposited 2022-06-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–1344（1344 aa）
Chain B 1–1344（1344 aa）
Chain C 1–1344（1344 aa）
Chain D 1–1344（1344 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8DDR cryo-EM structure of TRPM3 ion channel in the absence of PIP2 Deposited 2022-06-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–1344（1343 aa）
Chain B 2–1344（1343 aa）
Chain C 2–1344（1343 aa）
Chain D 2–1344（1343 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8DDS cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state1 Deposited 2022-06-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–1371（1370 aa）
Chain B 2–1371（1370 aa）
Chain C 2–1371（1370 aa）
Chain D 2–1371（1370 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8DDT cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state2 Deposited 2022-06-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–1371（1371 aa）
Chain B 1–1371（1371 aa）
Chain C 1–1371（1371 aa）
Chain D 1–1371（1371 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8DDU cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3 Deposited 2022-06-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–1371（1371 aa）
Chain B 1–1371（1371 aa）
Chain C 1–1371（1371 aa）
Chain D 1–1371（1371 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8DDV Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4 Deposited 2022-06-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–1371（1370 aa）
Chain B 2–1371（1370 aa）
Chain C 2–1371（1370 aa）
Chain D 2–1371（1370 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8DDW cryo-EM structure of TRPM3 ion channel in complex with Gbg, tethered by ALFA-nanobody Deposited 2022-06-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain A 1–1371（1371 aa）
Chain B 1–1371（1371 aa）
Chain C 1–1371（1371 aa）
Chain D 1–1371（1371 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.70 Å
8DDX cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody Deposited 2022-06-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain A 2–1371（1370 aa）
Chain B 2–1371（1370 aa）
Chain C 2–1371（1370 aa）
Chain D 2–1371（1370 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8ED7 cryo-EM structure of TRPM3 ion channel in apo state Deposited 2022-09-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–1344（1344 aa）
Chain B 1–1344（1344 aa）
Chain C 1–1344（1344 aa）
Chain D 1–1344（1344 aa）
Not recorded 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8ED8 cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1 Deposited 2022-09-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–1344（1344 aa）
Chain B 1–1344（1344 aa）
Chain C 1–1344（1344 aa）
Chain D 1–1344（1344 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8ED9 cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2 Deposited 2022-09-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–1344（1343 aa）
Chain B 2–1344（1343 aa）
Chain C 2–1344（1343 aa）
Chain D 2–1344（1343 aa）
Not recorded 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9B28 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone Deposited 2024-03-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1709（1709 aa）
Chain B 1–1709（1709 aa）
Chain C 1–1709（1709 aa）
Chain D 1–1709（1709 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 8 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A1AIA primidone × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.24 Å
9B29 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate Deposited 2024-03-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1709（1709 aa）
Chain B 1–1709（1709 aa）
Chain C 1–1709（1709 aa）
Chain D 1–1709（1709 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 4 Y01 CHOLESTEROL HEMISUCCINATE × 8 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
9B2A Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216 Deposited 2024-03-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1709（1709 aa）
Chain B 1–1709（1709 aa）
Chain C 1–1709（1709 aa）
Chain D 1–1709（1709 aa）
Not recorded A1AIB (2S)-2-(3,4-dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide × 4 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A8W Pregnenolone sulfate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.82 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.