当前蛋白身份:Q5F4S7
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差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 6RMV The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer 提交 2019-05-07 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致 |
链 C
592–606(15 aa)
|
未记录 | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP;pH 7.5;291.15 K;0.1 M HEPES sodium pH 7.5, 15% (w/v) polyethylene glycol 4,000, 7.5% (v/v) isopropanol
|
分辨率 1.94 Å R-free 0.224 |
| 8DDQ cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel 提交 2022-06-18 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
1–1344(1344 aa)
链 B
1–1344(1344 aa)
链 C
1–1344(1344 aa)
链 D
1–1344(1344 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 2.70 Å |
| 8DDR cryo-EM structure of TRPM3 ion channel in the absence of PIP2 提交 2022-06-18 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
2–1344(1343 aa)
链 B
2–1344(1343 aa)
链 C
2–1344(1343 aa)
链 D
2–1344(1343 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.20 Å |
| 8DDS cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state1 提交 2022-06-18 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
2–1371(1370 aa)
链 B
2–1371(1370 aa)
链 C
2–1371(1370 aa)
链 D
2–1371(1370 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.50 Å |
| 8DDT cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state2 提交 2022-06-18 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
1–1371(1371 aa)
链 B
1–1371(1371 aa)
链 C
1–1371(1371 aa)
链 D
1–1371(1371 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.10 Å |
| 8DDU cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3 提交 2022-06-19 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
1–1371(1371 aa)
链 B
1–1371(1371 aa)
链 C
1–1371(1371 aa)
链 D
1–1371(1371 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.00 Å |
| 8DDV Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4 提交 2022-06-19 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
2–1371(1370 aa)
链 B
2–1371(1370 aa)
链 C
2–1371(1370 aa)
链 D
2–1371(1370 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.20 Å |
| 8DDW cryo-EM structure of TRPM3 ion channel in complex with Gbg, tethered by ALFA-nanobody 提交 2022-06-19 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致 |
链 A
1–1371(1371 aa)
链 B
1–1371(1371 aa)
链 C
1–1371(1371 aa)
链 D
1–1371(1371 aa)
|
未记录 | 未记录非水小分子 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 4.70 Å |
| 8DDX cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody 提交 2022-06-19 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致 |
链 A
2–1371(1370 aa)
链 B
2–1371(1370 aa)
链 C
2–1371(1370 aa)
链 D
2–1371(1370 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.80 Å |
| 8ED7 cryo-EM structure of TRPM3 ion channel in apo state 提交 2022-09-03 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
1–1344(1344 aa)
链 B
1–1344(1344 aa)
链 C
1–1344(1344 aa)
链 D
1–1344(1344 aa)
|
未记录 | 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.70 Å |
| 8ED8 cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1 提交 2022-09-03 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
1–1344(1344 aa)
链 B
1–1344(1344 aa)
链 C
1–1344(1344 aa)
链 D
1–1344(1344 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.20 Å |
| 8ED9 cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2 提交 2022-09-03 | Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致 |
链 A
2–1344(1343 aa)
链 B
2–1344(1343 aa)
链 C
2–1344(1343 aa)
链 D
2–1344(1343 aa)
|
未记录 | 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8.5
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.40 Å |
| 9B28 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone 提交 2024-03-14 | Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致 |
链 A
1–1709(1709 aa)
链 B
1–1709(1709 aa)
链 C
1–1709(1709 aa)
链 D
1–1709(1709 aa)
|
未记录 | Y01 CHOLESTEROL HEMISUCCINATE × 8 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A1AIA primidone × 4 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.24 Å |
| 9B29 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate 提交 2024-03-14 | Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致 |
链 A
1–1709(1709 aa)
链 B
1–1709(1709 aa)
链 C
1–1709(1709 aa)
链 D
1–1709(1709 aa)
|
未记录 | 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 4 Y01 CHOLESTEROL HEMISUCCINATE × 8 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 4 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.13 Å |
| 9B2A Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216 提交 2024-03-14 | Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致 |
链 A
1–1709(1709 aa)
链 B
1–1709(1709 aa)
链 C
1–1709(1709 aa)
链 D
1–1709(1709 aa)
|
未记录 | A1AIB (2S)-2-(3,4-dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide × 4 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A8W Pregnenolone sulfate × 4 | ELECTRON MICROSCOPY |
cryo-EM缓冲液
pH 8
cryo-EM玻璃化条件
冷冻剂 ETHANE
|
分辨率 3.82 Å |