当前蛋白身份:Q5F4S7 重新检索
本组结构的主要差异维度
构建体不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
6RMV The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer 提交 2019-05-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 592–606(15 aa)
未记录 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;291.15 K;0.1 M HEPES sodium pH 7.5, 15% (w/v) polyethylene glycol 4,000, 7.5% (v/v) isopropanol
分辨率 1.94 Å R-free 0.224
8DDQ cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel 提交 2022-06-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–1344(1344 aa)
链 B 1–1344(1344 aa)
链 C 1–1344(1344 aa)
链 D 1–1344(1344 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.70 Å
8DDR cryo-EM structure of TRPM3 ion channel in the absence of PIP2 提交 2022-06-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 2–1344(1343 aa)
链 B 2–1344(1343 aa)
链 C 2–1344(1343 aa)
链 D 2–1344(1343 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
8DDS cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state1 提交 2022-06-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 2–1371(1370 aa)
链 B 2–1371(1370 aa)
链 C 2–1371(1370 aa)
链 D 2–1371(1370 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.50 Å
8DDT cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state2 提交 2022-06-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–1371(1371 aa)
链 B 1–1371(1371 aa)
链 C 1–1371(1371 aa)
链 D 1–1371(1371 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
8DDU cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3 提交 2022-06-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–1371(1371 aa)
链 B 1–1371(1371 aa)
链 C 1–1371(1371 aa)
链 D 1–1371(1371 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
8DDV Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4 提交 2022-06-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 2–1371(1370 aa)
链 B 2–1371(1370 aa)
链 C 2–1371(1370 aa)
链 D 2–1371(1370 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
8DDW cryo-EM structure of TRPM3 ion channel in complex with Gbg, tethered by ALFA-nanobody 提交 2022-06-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致
链 A 1–1371(1371 aa)
链 B 1–1371(1371 aa)
链 C 1–1371(1371 aa)
链 D 1–1371(1371 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.70 Å
8DDX cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody 提交 2022-06-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致
链 A 2–1371(1370 aa)
链 B 2–1371(1370 aa)
链 C 2–1371(1370 aa)
链 D 2–1371(1370 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
8ED7 cryo-EM structure of TRPM3 ion channel in apo state 提交 2022-09-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–1344(1344 aa)
链 B 1–1344(1344 aa)
链 C 1–1344(1344 aa)
链 D 1–1344(1344 aa)
未记录 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.70 Å
8ED8 cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1 提交 2022-09-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–1344(1344 aa)
链 B 1–1344(1344 aa)
链 C 1–1344(1344 aa)
链 D 1–1344(1344 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
8ED9 cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2 提交 2022-09-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 2–1344(1343 aa)
链 B 2–1344(1343 aa)
链 C 2–1344(1343 aa)
链 D 2–1344(1343 aa)
未记录 3PH 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE × 4 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
9B28 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone 提交 2024-03-14 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–1709(1709 aa)
链 B 1–1709(1709 aa)
链 C 1–1709(1709 aa)
链 D 1–1709(1709 aa)
未记录 Y01 CHOLESTEROL HEMISUCCINATE × 8 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A1AIA primidone × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.24 Å
9B29 Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate 提交 2024-03-14 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–1709(1709 aa)
链 B 1–1709(1709 aa)
链 C 1–1709(1709 aa)
链 D 1–1709(1709 aa)
未记录 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 4 Y01 CHOLESTEROL HEMISUCCINATE × 8 PX2 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.13 Å
9B2A Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216 提交 2024-03-14 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–1709(1709 aa)
链 B 1–1709(1709 aa)
链 C 1–1709(1709 aa)
链 D 1–1709(1709 aa)
未记录 A1AIB (2S)-2-(3,4-dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide × 4 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 4 A8W Pregnenolone sulfate × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.82 Å