当前蛋白身份:Q6TQR6 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
3PHU OTU Domain of Crimean Congo Hemorrhagic Fever Virus 提交 2010-11-04 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–217(217 aa) 片段:UNP residues 1-217
非标准单体:是(mmCIF未提供具体位点) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;3.9M NaFormate, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.20 Å R-free 0.231
3PHU OTU Domain of Crimean Congo Hemorrhagic Fever Virus 提交 2010-11-04 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–217(217 aa) 片段:UNP residues 1-217
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;3.9M NaFormate, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.20 Å R-free 0.231
3PHW OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin 提交 2010-11-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–183(183 aa) 片段:UNP residues 1-183
未记录 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;0.27 M sodium phosphate dihydrogen, 1.53 M di-potassium phosphate hydrogen, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.00 Å R-free 0.278
3PHW OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin 提交 2010-11-04 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–183(183 aa) 片段:UNP residues 1-183
未记录 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;0.27 M sodium phosphate dihydrogen, 1.53 M di-potassium phosphate hydrogen, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.00 Å R-free 0.278
3PHW OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin 提交 2010-11-04 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 1–183(183 aa) 片段:UNP residues 1-183
未记录 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;0.27 M sodium phosphate dihydrogen, 1.53 M di-potassium phosphate hydrogen, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.00 Å R-free 0.278
3PHW OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin 提交 2010-11-04 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 1–183(183 aa) 片段:UNP residues 1-183
未记录 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;0.27 M sodium phosphate dihydrogen, 1.53 M di-potassium phosphate hydrogen, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.00 Å R-free 0.278
3PHX OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with ISG15 提交 2010-11-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–183(183 aa) 片段:UNP residues 1-183
未记录 ZN ZINC ION × 12 ACY ACETIC ACID × 2 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;10% PEG8K, 0.2M zinc acetate, 0.1M MES sodium salt, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 1.60 Å R-free 0.192
3PHX OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with ISG15 提交 2010-11-04 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–183(183 aa) 片段:UNP residues 1-183
未记录 ZN ZINC ION × 12 ACY ACETIC ACID × 2 NEH ETHANAMINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;10% PEG8K, 0.2M zinc acetate, 0.1M MES sodium salt, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 1.60 Å R-free 0.192
3PRM Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin 提交 2010-11-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–170(170 aa)
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;298 K;22-26% PEG 8000, 0.1 M Na cacodylate, 0.2 M Mg acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.267
3PRM Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin 提交 2010-11-30 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–170(170 aa)
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;298 K;22-26% PEG 8000, 0.1 M Na cacodylate, 0.2 M Mg acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.267
3PRP Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin 提交 2010-11-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–170(170 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;298 K;22-28% PEG 8000, 100 mM Na cacodylate pH 6.5, 100-250 mM Mg acetate, and 2% n-Octyl- -D-glucoside, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 1.70 Å R-free 0.212
3PRP Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin 提交 2010-11-30 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–170(170 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;298 K;22-28% PEG 8000, 100 mM Na cacodylate pH 6.5, 100-250 mM Mg acetate, and 2% n-Octyl- -D-glucoside, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 1.70 Å R-free 0.212
3ZNH Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl. 提交 2013-02-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–183(183 aa) 片段:OTU DOMAIN, RESIDUES 1-183
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;20-30% PEG 8000, 100 MM NA CACODYLATE PH 6.5, 100 MM MG ACETATE, AND 2% N-OCTYL-BETA-D-GLUCOSIDE.
分辨率 2.30 Å R-free 0.275
5V5G OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4 提交 2017-03-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–183(183 aa)
非标准单体:是(mmCIF未提供具体位点) EDO 1,2-ETHANEDIOL × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;293 K;25% (w/v) PEG3350, 0.1 M Tris pH 7.0, 0.2 M sodium chloride and Silver Bullet formulation #G1 (0.16% (w/v) each of 5-Sulfosalicylic acid dehydrate, dodecanedioic acid, hippuric acid, mellitic acid, oxalacetic acid, suberic acid and 0.02 M HEPES sodium pH 6.8)
分辨率 2.10 Å R-free 0.229
5V5G OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4 提交 2017-03-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–183(183 aa)
非标准单体:是(mmCIF未提供具体位点) EDO 1,2-ETHANEDIOL × 1 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;293 K;25% (w/v) PEG3350, 0.1 M Tris pH 7.0, 0.2 M sodium chloride and Silver Bullet formulation #G1 (0.16% (w/v) each of 5-Sulfosalicylic acid dehydrate, dodecanedioic acid, hippuric acid, mellitic acid, oxalacetic acid, suberic acid and 0.02 M HEPES sodium pH 6.8)
分辨率 2.10 Å R-free 0.229
5V5H OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.2 提交 2017-03-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–169(169 aa)
非标准单体:是(mmCIF未提供具体位点) NA SODIUM ION × 1 ZN ZINC ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;277 K;30% (w/v) PEG 4000, 0.2 M CaCl2 and 0.1 M HEPES pH 7.5
分辨率 1.50 Å R-free 0.178
5V5I OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.1 提交 2017-03-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–169(169 aa)
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;277 K;30% (w/v) PEG6000, 1.0M lithium chloride and 0.1M sodium acetate
分辨率 2.20 Å R-free 0.273
5V5I OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.1 提交 2017-03-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–169(169 aa)
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;277 K;30% (w/v) PEG6000, 1.0M lithium chloride and 0.1M sodium acetate
分辨率 2.20 Å R-free 0.273
9XD4 Crimean-Congo hemorrhagic fever virus RNA polymerase 提交 2025-10-27 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–3945(3945 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.79 Å
9XD5 Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 5' vRNA 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:dimeric(2) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.72 Å
9XD6 Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 3' vRNA 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:dimeric(2) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.74 Å
9XE6 Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 10-bp RNA product and incorporated 2FC 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 2KH 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine × 1 MN MANGANESE (II) ION × 4 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.09 Å
9XE7 Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 10-bp RNA product and incorporated cytidine 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 2KH 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine × 1 MN MANGANESE (II) ION × 4 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.02 Å
9XE9 Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 15-bp RNA product 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 MN MANGANESE (II) ION × 4 2KH 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.81 Å
9XEC Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 9-bp RNA product 提交 2025-10-27 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 MN MANGANESE (II) ION × 4 2KH 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.98 Å
9YBM 2.62A cryo-EM structure of RNA-directed RNA polymerase L of Crimean-Congo hemorrhagic fever virus (Apo state) 提交 2025-09-17 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–3945(3945 aa)
未记录 ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.62 Å
9YBN 2.53A cryo-EM structure of RNA-directed RNA polymerase L of Crimean-Congo hemorrhagic fever virus (RNA bound) 提交 2025-09-17 Assembly 1 蛋白–RNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 A 1–3945(3945 aa)
未记录 ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.53 Å