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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9BYX4 New Search
9PDB entries
10Biological assembly
19chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2RQB Solution structure of MDA5 CTD Deposited 2009-03-17 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 896–1025（130 aa） Fragment：UNP residues 896-1025
Not recorded ZN ZINC ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.25；Pressure ambient
NMR sample composition 1mM [U-100% 13C; U-100% 15N] MDA5, 20mM Bis-Tris-2, 250mM sodium chloride-3, 10mM DTT-4, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3B6E Crystal structure of human DECH-box RNA Helicase MDA5 (Melanoma differentiation-associated protein 5), DECH-domain Deposited 2007-10-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 277–490（214 aa） Fragment：DECH domain: Residues 277-490
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；298 K；1.2M Sodium citrate, 0.1M Tris-HCl, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.60 Å R-free 0.204
3GA3 Crystal structure of the C-terminal domain of human MDA5 Deposited 2009-02-16 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 893–1017（125 aa） Fragment：C-terminal domain, residues 893-1017
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 8.5；277 K；0.1 M Tris, 14 to 18% ethanol, pH 8.5, EVAPORATION, temperature 277K
Resolution 1.45 Å R-free 0.204
4GL2 Structural Basis for dsRNA duplex backbone recognition by MDA5 Deposited 2012-08-13 Assembly 1 Protein–RNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 306–1017（712 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.56 Å R-free 0.320
4GL2 Structural Basis for dsRNA duplex backbone recognition by MDA5 Deposited 2012-08-13 Assembly 2 Protein–RNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain B 306–1017（712 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.56 Å R-free 0.320
7DNI MDA5 CARDs-MAVS CARD polyUb complex Deposited 2020-12-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain A 1–208（208 aa）
Chain B 1–208（208 aa）
Chain C 1–208（208 aa）
Chain D 1–208（208 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
Resolution 3.20 Å
7DNJ K63-polyUb MDA5CARDs complex Deposited 2020-12-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–208（208 aa）
Chain B 1–208（208 aa）
Chain C 1–208（208 aa）
Chain D 1–208（208 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen OTHER
Resolution 3.30 Å
7JL0 Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer) Deposited 2020-07-29 Assembly 1 Protein–RNA Heteromer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 287–1025（739 aa） Fragment：UNP residues 287-1025
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
7JL2 Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer) Deposited 2020-07-29 Assembly 1 Protein–RNA Heteromer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain A 287–1025（739 aa） Fragment：UNP residues 287-1025
Chain C 287–1025（739 aa） Fragment：UNP residues 287-1025
Chain E 287–1025（739 aa） Fragment：UNP residues 287-1025
Not recorded ZN ZINC ION × 3 ADP ADENOSINE-5'-DIPHOSPHATE × 3 ALF TETRAFLUOROALUMINATE ION × 3 MG MAGNESIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
9LOV LGP2:MDA5:dsRNA filament Deposited 2025-01-23 Assembly 1 Protein–RNA Heteromer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain B 287–1025（739 aa）
Chain C 287–1025（739 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 3 ZN ZINC ION × 3 MG MAGNESIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.