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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9ULV1 New Search
11PDB entries
19Biological assembly
22chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5BPB Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I Deposited 2015-05-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 42–179（138 aa） Fragment：UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；1.6 M tri-sodium citrate, pH 6.5
Resolution 2.20 Å R-free 0.223
5BPB Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I Deposited 2015-05-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 42–179（138 aa） Fragment：UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；1.6 M tri-sodium citrate, pH 6.5
Resolution 2.20 Å R-free 0.223
5BPB Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I Deposited 2015-05-27 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 42–179（138 aa） Fragment：UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；1.6 M tri-sodium citrate, pH 6.5
Resolution 2.20 Å R-free 0.223
5BPB Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I Deposited 2015-05-27 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 42–179（138 aa） Fragment：UNP residues 42-179
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；1.6 M tri-sodium citrate, pH 6.5
Resolution 2.20 Å R-free 0.223
5BPQ Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II Deposited 2015-05-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 42–179（138 aa） Fragment：cysteine-rich domain, UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M HEPES, pH 7.5, 0.1 M NaCl, 1.6 M ammonium sulfate
Resolution 2.40 Å R-free 0.243
5BPQ Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II Deposited 2015-05-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 42–179（138 aa） Fragment：cysteine-rich domain, UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M HEPES, pH 7.5, 0.1 M NaCl, 1.6 M ammonium sulfate
Resolution 2.40 Å R-free 0.243
5BPQ Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II Deposited 2015-05-28 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 42–179（138 aa） Fragment：cysteine-rich domain, UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M HEPES, pH 7.5, 0.1 M NaCl, 1.6 M ammonium sulfate
Resolution 2.40 Å R-free 0.243
5BPQ Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II Deposited 2015-05-28 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 42–179（138 aa） Fragment：cysteine-rich domain, UNP residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M HEPES, pH 7.5, 0.1 M NaCl, 1.6 M ammonium sulfate
Resolution 2.40 Å R-free 0.243
5BQC Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and sucrose octasulfate Deposited 2015-05-28 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 42–179（138 aa） Fragment：residues 42-179
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M Tris, pH 8.0, 0.15 M NaCl, 8% PEG8000
Resolution 3.00 Å R-free 0.268
5BQE Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 -Methylated form Deposited 2015-05-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 42–179（138 aa） Fragment：residues 42-179
Non-standard monomer：Yes (specific site not provided by mmCIF) PG0 2-(2-METHOXYETHOXY)ETHANOL × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M Bicine, pH 9.0, 10% PEG6000
Resolution 2.30 Å R-free 0.221
5CL1 Complex structure of Norrin with human Frizzled 4 Deposited 2015-07-16 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 38–160（123 aa） Fragment：UNP residues 38-160
Chain D 38–160（123 aa） Fragment：UNP residues 38-160
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；200 mM ammonium sulfate, 100 mM sodium cacodylate trihydrate (pH 6.5), 15% w/v polyethylene glycol 8,000
Resolution 3.80 Å R-free 0.310
5CM4 Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD) Deposited 2015-07-16 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 40–164（125 aa） Fragment：UNP residues 40-164
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；1.8 M ammonium sulfate, 0.1 M tri-Na citrate pH 5.6 and 0.2 M Na/K tartrate
Resolution 2.40 Å R-free 0.255
5CM4 Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD) Deposited 2015-07-16 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 40–164（125 aa） Fragment：UNP residues 40-164
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；1.8 M ammonium sulfate, 0.1 M tri-Na citrate pH 5.6 and 0.2 M Na/K tartrate
Resolution 2.40 Å R-free 0.255
5UWG The crystal structure of Fz4-CRD in complex with palmitoleic acid Deposited 2017-02-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 40–164（125 aa） Fragment：Cysteine Rich Domain (UNP residues 40-164)
Not recorded PAM PALMITOLEIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 3.5；293 K；0.1 M citric acid pH 3.5, 28% w/v polyethylene glycol 8,000
Resolution 2.56 Å R-free 0.267
5UWG The crystal structure of Fz4-CRD in complex with palmitoleic acid Deposited 2017-02-21 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 40–164（125 aa） Fragment：Cysteine Rich Domain (UNP residues 40-164)
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 3.5；293 K；0.1 M citric acid pH 3.5, 28% w/v polyethylene glycol 8,000
Resolution 2.56 Å R-free 0.267
6BD4 Crystal structure of human apo-Frizzled4 receptor Deposited 2017-10-21 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 178–419（242 aa）
Chain A 428–517（90 aa）
Mutation：M309L, C450I, C507F, S508Y Mutation：M309L, C450I, C507F, S508Y ZN ZINC ION × 1 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 OLA OLEIC ACID × 5 SO4 SULFATE ION × 3 UNX UNKNOWN LIGAND × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 6；293 K；100 mM sodium cacodylate trihydrate (pH 6.0), 80 mM Magnesium Sulfate, 30% PEG400, 1.5-2.5% v/v (+/-)-2-Methyl-2,4-pentanediol
Resolution 2.40 Å R-free 0.233
6NE1 Designed repeat protein in complex with Fz4 Deposited 2018-12-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 42–161（120 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；0.2 M ammonium chloride, pH 6.3 and 20% PEG3,350
Resolution 3.01 Å R-free 0.293
8WM9 Fzd4/DEP complex Deposited 2023-10-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–537（537 aa）
Chain B 1–537（537 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.53 Å
8WMA Fzd4/DEP complex (local refined) Deposited 2023-10-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–537（537 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.47 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.