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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9UQM7 New Search
22PDB entries
29Biological assembly
76chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2VZ6 Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804 Deposited 2008-07-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 13–302（290 aa） Fragment：KINASE DOMAIN, RESIDUES 13-302
Not recorded FEF (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} × 1 PGO S-1,2-PROPANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；12% PEG6000, 0.1M TRIS PH8.5
Resolution 2.30 Å R-free 0.203
2VZ6 Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804 Deposited 2008-07-30 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 13–302（290 aa） Fragment：KINASE DOMAIN, RESIDUES 13-302
Not recorded FEF (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} × 1 PGO S-1,2-PROPANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；12% PEG6000, 0.1M TRIS PH8.5
Resolution 2.30 Å R-free 0.203
3SOA Full-length human CaMKII Deposited 2011-06-30 Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–474（474 aa）
Mutation：K42M, D135N, T306V DB8 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；288.15 K；1.2 M Ammonium Tartrate, 100 mM bistrispropane, pH 5.5, VAPOR DIFFUSION, temperature 288.15K
Resolution 3.55 Å R-free 0.327
5IG3 Crystal structure of the human CaMKII-alpha hub Deposited 2016-02-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 345–475（131 aa） Fragment：UNP residues 345-475
Chain B 345–475（131 aa） Fragment：UNP residues 345-475
Chain C 345–475（131 aa） Fragment：UNP residues 345-475
Chain D 345–475（131 aa） Fragment：UNP residues 345-475
Chain E 345–475（131 aa） Fragment：UNP residues 345-475
Chain F 345–475（131 aa） Fragment：UNP residues 345-475
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.3；295 K；35 % (v/v) MPD, 0.1 M HEPES pH 7.3
Resolution 2.75 Å R-free 0.268
6OF8 Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain Deposited 2019-03-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 345–475（131 aa）
Chain B 345–475（131 aa）
Chain C 345–475（131 aa）
Chain D 345–475（131 aa）
Chain E 345–475（131 aa）
Chain F 345–475（131 aa）
Chain G 345–475（131 aa）
Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M K POTASSIUM ION × 10 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；17 mg/mL mutant hub in 25 mM Tris, 150 mM KCl, 10% (v/v) glycerol, 2 mM DTT, 1 mM TCEP, pH 8.0 was mixed 1:1 with 235 mM K3Citrate, 15% (w/v) PEG 3350, pH 8.0
Resolution 2.10 Å R-free 0.258
6VZK Crystal structure of human CaMKII-alpha (CAMK2A)kinase domain Deposited 2020-02-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K HC4 4'-HYDROXYCINNAMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 6000, 50 mM HEPES, 3-Aminobenzene-sulfonic acid, 5-Sulfosalicylic acid dihydrate, p-Coumaric acid, PIPES, Terephthalic acid, Vanillic acid
Resolution 2.55 Å R-free 0.294
6W4O CaMKII alpha-30 Cryo-EM reconstruction Deposited 2020-03-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 13 PDB declaration: tridecameric（13） Consistent with protein count
Chain A 7–478（472 aa）
Chain B 7–478（472 aa）
Chain C 7–478（472 aa）
Chain D 7–478（472 aa）
Chain E 7–478（472 aa）
Chain F 7–478（472 aa）
Chain G 7–478（472 aa）
Chain I 7–478（472 aa）
Chain J 7–478（472 aa）
Chain K 7–478（472 aa）
Chain L 7–478（472 aa）
Chain M 7–478（472 aa）
Chain O 7–478（472 aa）
Mutation：K37M No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
6W4P CaMKII alpha-30 Cryo-EM reconstruction - Class B Deposited 2020-03-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 13 PDB declaration: tridecameric（13） Consistent with protein count
Chain A 7–478（472 aa）
Chain B 7–478（472 aa）
Chain C 7–478（472 aa）
Chain D 7–478（472 aa）
Chain E 7–478（472 aa）
Chain F 7–478（472 aa）
Chain G 7–478（472 aa）
Chain H 7–478（472 aa）
Chain I 7–478（472 aa）
Chain J 7–478（472 aa）
Chain K 7–478（472 aa）
Chain L 7–478（472 aa）
Chain M 7–478（472 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.60 Å
6X5G Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and LRRC7 inhibitory domain Deposited 2020-05-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K GOL GLYCEROL × 2 BCN BICINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；277 K；10% w/v PEG 20000, 2% v/v 1,4-Dioxane, 0.1 M Bicine
Resolution 1.85 Å R-free 0.227
6X5Q Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluA1 Deposited 2020-05-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；0.1 M Tris, 28% w/v PEG 4000
Resolution 2.14 Å R-free 0.235
7KL0 Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2020-10-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K UZD methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 6000, 19mM HECAMEG
Resolution 2.40 Å R-free 0.258
7KL0 Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2020-10-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K UZD methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 6000, 19mM HECAMEG
Resolution 2.40 Å R-free 0.258
7KL1 Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2020-10-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K EDO 1,2-ETHANEDIOL × 1 MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 6000, 19mM HECAMEG
Resolution 2.40 Å R-free 0.258
7KL1 Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2020-10-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K EDO 1,2-ETHANEDIOL × 2 MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 6000, 19mM HECAMEG
Resolution 2.40 Å R-free 0.258
7KL2 Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2020-10-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.15 M DL-Malic acid pH 7, 20% PEG 3350
Resolution 2.56 Å R-free 0.293
7REC Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC Deposited 2021-07-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain B 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain C 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain D 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain E 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain F 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Chain G 345–475（131 aa） Fragment：hub (UNP residues 345-475)
Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M Mutation：T354N, E355Q, T412N, I414M, I464H, F467M 7ZV 5-hydroxydiclofenac × 12 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.1；298 K；100 nL protein + compound in 25 mM Tris, 150 mM potassium chloride, 2 mM DTT, 1 mM TCEP, 10% v/v glycerol, pH 8.0, 10% DMSO + 100 nL well solution (200 mM potassium acetate, 20% w/v PEG3350, pH 8.1), equilibrated against 45 uL well solution
Resolution 2.20 Å R-free 0.244
7UIQ Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 Deposited 2022-03-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M HEPES, 16% PEG 6000, 0.1% v/v Triton X-114
Resolution 3.11 Å R-free 0.309
7UIQ Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 Deposited 2022-03-29 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M HEPES, 16% PEG 6000, 0.1% v/v Triton X-114
Resolution 3.11 Å R-free 0.309
7UIR Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP Deposited 2022-03-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M HEPES, 16% PEG 6000, 0.1% v/v Triton X-114
Resolution 3.10 Å R-free 0.274
7UIR Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP Deposited 2022-03-29 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K ATP ADENOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M HEPES, 16% PEG 6000, 0.1% v/v Triton X-114
Resolution 3.10 Å R-free 0.274
7UIS Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Deposited 2022-03-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M Bis-tris propane pH 6.5, 0.2 M Sodium chloride, 25% PEG 3350
Resolution 2.58 Å R-free 0.268
7UJP Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B Deposited 2022-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1 M Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, 0.1 M Ammonium sulfate, 25% PEG 3350, 19mM Methyl 6-O-(N-heptylcarbamoyl)-alpha-D-glucopyranoside
Resolution 2.56 Å R-free 0.281
7UJP Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B Deposited 2022-03-31 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1 M Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, 0.1 M Ammonium sulfate, 25% PEG 3350, 19mM Methyl 6-O-(N-heptylcarbamoyl)-alpha-D-glucopyranoside
Resolution 2.56 Å R-free 0.281
7UJQ Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B Deposited 2022-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K UZD methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1 M Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, 0.1 M Ammonium sulfate, 25% PEG 3350, 19mM Methyl 6-O-(N-heptylcarbamoyl)-alpha-D-glucopyranoside
Resolution 2.25 Å R-free 0.271
7UJQ Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B Deposited 2022-03-31 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–274（268 aa）
Mutation：D135N, Q223K UZD methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1 M Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, 0.1 M Ammonium sulfate, 25% PEG 3350, 19mM Methyl 6-O-(N-heptylcarbamoyl)-alpha-D-glucopyranoside
Resolution 2.25 Å R-free 0.271
7UJR Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B Deposited 2022-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：Q223K EDO 1,2-ETHANEDIOL × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 3350, 5% Ethanol
Resolution 1.95 Å R-free 0.252
7UJS Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B in complex with ADP Deposited 2022-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：Q223K ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.1 M Ammonium sulfate, 20% PEG 3350
Resolution 2.75 Å R-free 0.262
7UJT Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) in complex with ATP Deposited 2022-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–274（268 aa）
Mutation：D135N, Q223K ATP ADENOSINE-5'-TRIPHOSPHATE × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M 1,3-bis(tris(hydroxymethyl)methylamino)propane, 0.2 M Sodium chloride, 25% PEG 3350
Resolution 2.10 Å R-free 0.246
9EOY Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to PIPA Deposited 2024-03-15 Assembly 1 Protein homooligomer Homooligomer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 345–475（131 aa）
Chain B 345–475（131 aa）
Chain C 345–475（131 aa）
Chain D 345–475（131 aa）
Chain E 345–475（131 aa）
Chain F 345–475（131 aa）
Chain G 345–475（131 aa）
Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M Mutation：T354N, E355Q, T412N, I414M, I464H, and F467M ACT ACETATE ION × 12 A1H6K 2-[6-(4-chlorophenyl)imidazo[1,2-b]pyridazin-2-yl]ethanoic acid × 4 PG4 TETRAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；500 nL protein + 2.65 mM compound in 25 mM Tris, 150 mM KCl, 10 mM imidazole, 1 mM DTT, 10% glycerol, pH 8.5, 10% DMSO + 1000 nL well solution (11% w/v PEG3350, 300 mM potassium acetate, pH 8.0), equilibrated against 50 uL well solution.
Resolution 2.10 Å R-free 0.251

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.