查看完整 summary.json 原文
{
"code": "SASDVC5",
"status": "Published",
"type_of_curve": "SEC-SAS",
"angular_unit": "1/A",
"project": {
"title": "The sequence–structure–function relationship of intrinsic ERα disorder",
"publication": {
"title": "The sequence–structure–function relationship of intrinsic ERα disorder",
"author_list": "Du Z, Wang H, Luo S, Yun Z, Wu C, Yang W, Buck M, Zheng W, Hansen A, Kao H, Yang S",
"journal": "Nature",
"doi": "10.1038/s41586-024-08400-1",
"pmid": null,
"published_date": "2025 Jan 08"
},
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"submitted_date": "2024-07-23",
"released_date": "2024-12-13"
},
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"resolution": null
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"name": "National Synchrotron Light Source II (NSLS-II)",
"city": "Upton, NY",
"country": "USA",
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{
"long_name": "Estrogen receptor",
"short_name": "ER-NTD",
"sequence": "SNAMTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRY",
"organism": "Homo sapiens",
"uniprot_code": "P03372",
"uniprot_range_first": 1,
"uniprot_range_last": 184,
"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY\nEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF\nLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK\nETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC\nRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR\nSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW\nAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG\nMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD\nKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL\nLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV",
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"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
}
],
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"concentration_unit": null,
"comment": null,
"additive": null,
"concentration": null,
"pka": null,
"ph": 7.4,
"deuteration": null
},
"purity_method": null,
"name": "SEC-SAXS data of phosphorylated estrogen receptor alpha (pSer118), N-terminal domain (NTD) at pH 7.4",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
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},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": "Cleveland, USA",
"full_name": "Case Western Reserve University",
"webpage": "https://case.edu/"
}
],
"contributor_name": "Sichun",
"contributor_surname": "Yang",
"orcid": null
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2024-07-17",
"storage_temperature": 8.0,
"cell_temperature": 4.0,
"exposure_time": 2.0,
"number_of_frames": 360,
"wavelength": 0.08189,
"sample_detector_distance": 4.003,
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"description": null,
"experiment_description": "Synchrotron SAXS data from solutions of the phosphorylated N-terminal domain of estrogen receptor alpha (pSer118) in 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP, pH 7.4 were collected on the 16-ID (LiX) beam line at the National Synchrotron Light Source II (NSLS-II; Upton, NY, USA) using a Pilatus3 S 1M, Pilatus3 900 K detector at a sample-detector distance of 4.0 m and at a wavelength of λ = 0.08189 nm (I(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). In-line size-exclusion chromatography (SEC) SAS was employed. The SEC parameters were as follows: A 100.00 μl sample at 2 mg/ml was injected at a 0.35 ml/min flow rate onto a Cytiva Superdex 75 Increase 5/150 column at 4°C. 360 successive 2 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted.",
"tags": [],
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"guinier_point_last": 30,
"pddf_point_first": null,
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"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDVC5_datloglog_img.png",
"symmetry": null,
"last_modified": "2025-01-08T17:59:15.079200+01:00",
"bragg_peak": []
}查看完整 manifest.json 原文
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