SAXSdb — 10gh

▼

1. Structure Basics

entry_id	10gh
deposition_date	2026-01-19
title	Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5
keywords	Receptor tyrosine kinase, ROS1 extracellular bent-over conformation, Inhibitory Fab-RX5, TRANSFERASE-IMMUNE SYSTEM complex; TRANSFERASE/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	55.81 Å
rg_electron	56.57 Å
i0	390157000.00
molecular_weight	165170.0 kDa
excluded_volume	207080 Å³
envelope_volume	298560 Å³
shell_volume	50590 Å³
envelope_diameter	236.1 Å
shell_rg	47.13 Å
envelope_rg	57.86 Å
shape_rg	56.55 Å
total_rg	56.28 Å
total_atoms	11659
n_residues	1474
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	212.3 Å
rg_real	56.86 Å
rg_real_error	3.67 Å
i0_real	3.9010e+08
i0_real_error	9.3590e+06
rg_reciprocal	54.92 Å
i0_reciprocal	389000000.0000
total_estimate	0.6778
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	37.9 Å
skewness	0.694
kurtosis	-0.174
angular_range	— – 0.1400 Å⁻¹
current_alpha	0.0000
highest_alpha	21460000.0000
n_real_points	29
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.321; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.204; Smooth: 0.640

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (5)

Entity 1 polymer

description	Proto-oncogene tyrosine-protein kinase ROS
formula_weight	112553.8 kDa
ec_number	2.7.10.1
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	11659

STVLSSCLTSCVTNLGRQLDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGSYEEEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAP

Source

organism	Mus musculus
common_name	house mouse
ncbi_taxonomy_id	10090
host_organism	Homo sapiens

Entity 2 polymer

description	Fab-RX5 light chain
formula_weight	25079.7 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

SMASDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYYAYSLFTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGSDYKDDDDK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 3 polymer

description	Fab-RX5 heavy chain
formula_weight	25503.3 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

EISEVQLVESGGGLVQPGGSLRLSCAASGFNLSSSSMHWVRQAPGKGLEWVAYIYPYSSSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSYWGYYGLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTSRHHHHHH

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 4 branched

description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	424.4 kDa
src_method	man
entity_count	3

Entity 5 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	5

▶

6. Citations (1)

▶

length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	triclinic

resolution	3.06 Å
resolution_method	—
num_particles	166992

fit	/app/data/saxs_computation/0g/10gh/10gh.fit
pddf	/app/data/pr_computation/0g/10gh/10gh.pr.out
profile	/app/data/saxs_computation/0g/10gh/10gh.dat

Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 branched

Entity 5 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)