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1a22

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

Method: X-RAY DIFFRACTION D_max: 78.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1a22
deposition_date	1998-01-15
title	HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
keywords	COMPLEX (HORMONE-RECEPTOR), PITUITARY, HORMONE, COMPLEX (HORMONE-RECEPTOR) complex; COMPLEX (HORMONE/RECEPTOR)
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	23.47 Å
rg_electron	22.88 Å
i0	31097300.00
molecular_weight	43191.0 kDa
excluded_volume	54133 Å³
envelope_volume	64325 Å³
shell_volume	23897 Å³
envelope_diameter	80.3 Å
shell_rg	29.25 Å
envelope_rg	23.41 Å
shape_rg	22.87 Å
total_rg	23.69 Å
total_atoms	3044
n_residues	372
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	78.1 Å
rg_real	23.46 Å
rg_real_error	0.57 Å
i0_real	3.1100e+07
i0_real_error	4.7550e+05
rg_reciprocal	23.46 Å
i0_reciprocal	31100000.0000
total_estimate	0.8107
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	27.6 Å
skewness	0.345
kurtosis	-0.300
angular_range	— – 0.3400 Å⁻¹
current_alpha	0.0000
highest_alpha	11020000.0000
n_real_points	66
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.850; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.985; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	GROWTH HORMONE
formula_weight	22252.1 kDa
mutation	G120R
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3113

FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEERIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 polymer

description	GROWTH HORMONE RECEPTOR
formula_weight	27409.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

FSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	69

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6. Citations (2)

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length_a	67.700 Å
length_b	67.700 Å
length_c	228.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 43 21 2
int_tables_number	96
crystal_system	—

resolution	2.600 Å
resolution_low	7.000 Å
r_factor	0.1870
r_work	0.1870
r_free	—

fit	/app/data/saxs_computation/a2/1a22/1a22.fit
pddf	/app/data/pr_computation/a2/1a22/1a22.pr.out
profile	/app/data/saxs_computation/a2/1a22/1a22.dat

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 water

6. Citations (2)

7. Files & Curves (10)

Files (7)

Curves (3)