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1b6c

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

Method: X-RAY DIFFRACTION D_max: 144.9 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1b6c
deposition_date	1999-01-13
title	CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12
keywords	COMPLEX (ISOMERASE-PROTEIN KINASE), RECEPTOR SERINE/THREONINE KINASE, COMPLEX (ISOMERASE-PROTEIN KINASE) complex; COMPLEX (ISOMERASE/PROTEIN KINASE)
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	45.94 Å
rg_electron	45.43 Å
i0	572217000.00
molecular_weight	195750.0 kDa
excluded_volume	244570 Å³
envelope_volume	339680 Å³
shell_volume	63229 Å³
envelope_diameter	152.0 Å
shell_rg	49.52 Å
envelope_rg	44.16 Å
shape_rg	45.39 Å
total_rg	45.74 Å
total_atoms	13752
n_residues	1732
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	144.9 Å
rg_real	45.77 Å
rg_real_error	1.56 Å
i0_real	5.7220e+08
i0_real_error	9.9090e+06
rg_reciprocal	45.94 Å
i0_reciprocal	572300000.0000
total_estimate	0.9059
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	1
r_peak_primary	59.7 Å
skewness	0.066
kurtosis	-0.741
angular_range	— – 0.1700 Å⁻¹
current_alpha	0.0000
highest_alpha	34910000.0000
n_real_points	35
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.951; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.920

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	FK506-BINDING PROTEIN
formula_weight	11836.5 kDa
ec_number	5.2.1.8
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,C,E,G
atom_count	13840

GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 polymer

description	TGF-B SUPERFAMILY RECEPTOR TYPE I
formula_weight	38920.6 kDa
ec_number	2.7.1.37
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	B,D,F,H

EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	4

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	88

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6. Citations (1)

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length_a	75.580 Å
length_b	81.060 Å
length_c	90.530 Å
angle_alpha	86.23 °
angle_beta	81.86 °
angle_gamma	63.92 °
z_pdb	4

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.600 Å
resolution_low	30.000 Å
r_factor	0.2490
r_work	0.2490
r_free	0.2690

fit	/app/data/saxs_computation/b6/1b6c/1b6c.fit
pddf	/app/data/pr_computation/b6/1b6c/1b6c.pr.out
profile	/app/data/saxs_computation/b6/1b6c/1b6c.dat

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)