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1b6c

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

FK506-BINDING PROTEIN

Homo sapiens

UniProt P62942

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 TGF-B SUPERFAMILY RECEPTOR TYPE I × 1 （P36897） SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 TGF-B SUPERFAMILY RECEPTOR TYPE I × 1 （P36897） SULFATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 TGF-B SUPERFAMILY RECEPTOR TYPE I × 1 （P36897） SULFATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 TGF-B SUPERFAMILY RECEPTOR TYPE I × 1 （P36897） SULFATE ION × 1 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 8 TGF-B SUPERFAMILY RECEPTOR TYPE I × 4 （P36897） SULFATE ION × 4 water × 8 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1f40 1fkb 1fkg 1fkh

79 assemblies; showing the first 12

Homodimer
1a7x 1bkf 1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1eym 1fkd

22 assemblies; showing the first 12

Homotetramer
1fkd 1fkj 1qpf 2fke

4 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1b6c 1b6c 1b6c 1b6c 1b6c 1bl4 1fap 1nsg 1tco 21kr 21ks 21kt

67 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FKB1A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–107； UniProt 1–107 Author chain C； PDBConstruct 1–107； UniProt 1–107 Author chain E； PDBConstruct 1–107； UniProt 1–107 Author chain G； PDBConstruct 1–107； UniProt 1–107

TGF-B SUPERFAMILY RECEPTOR TYPE I

Homo sapiens

UniProt P36897

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 FK506-BINDING PROTEIN × 1 （P62942） SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 FK506-BINDING PROTEIN × 1 （P62942） SULFATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 FK506-BINDING PROTEIN × 1 （P62942） SULFATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 FK506-BINDING PROTEIN × 1 （P62942） SULFATE ION × 1 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 8 FK506-BINDING PROTEIN × 4 （P62942） SULFATE ION × 4 water × 8 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1py5 1rw8 1vjy 2l5s 2wot 2wou 2x7o 2x7o 2x7o 2x7o 2x7o 3faa

50 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
1ias

1 assemblies

Heteromeric or nucleic-acid complex
1b6c 1b6c 1b6c 1b6c 1b6c 2pjy 3kfd 3kfd 3kfd 6mac 9b9f 9b9f

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TGFR1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–342； UniProt 162–503 Author chain D； PDBConstruct 1–342； UniProt 162–503 Author chain F； PDBConstruct 1–342； UniProt 162–503 Author chain H； PDBConstruct 1–342； UniProt 162–503

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1b6c
Deposition date deposition_date1999-01-13
Structure title titleCRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12
Keywords keywordsCOMPLEX (ISOMERASE-PROTEIN KINASE), RECEPTOR SERINE/THREONINE KINASE, COMPLEX (ISOMERASE-PROTEIN KINASE) complex; COMPLEX (ISOMERASE/PROTEIN KINASE)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1b6c__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1b6c__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1b6c__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.07 Å
Rg (electron density)24.31 Å
Total Rg25.12 Å
Atom count3438
Residues433
Excluded volume61143 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1b6c__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1b6c__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1b6c__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1b6c__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 1b6c__assembly_5__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 20 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1b6ca_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.26 — FKBP-like
Superfamily Superfamily superfamilyd.26.1 — FKBP-like
Family Family familyd.26.1.1 — FKBP immunophilin/proline isomerase
Domain ID domain_idd1b6cb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd1b6cc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.26 — FKBP-like
Superfamily Superfamily superfamilyd.26.1 — FKBP-like
Family Family familyd.26.1.1 — FKBP immunophilin/proline isomerase
Domain ID domain_idd1b6cd_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd1b6ce_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.26 — FKBP-like
Superfamily Superfamily superfamilyd.26.1 — FKBP-like
Family Family familyd.26.1.1 — FKBP immunophilin/proline isomerase
Domain ID domain_idd1b6cf_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd1b6cg_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.26 — FKBP-like
Superfamily Superfamily superfamilyd.26.1 — FKBP-like
Family Family familyd.26.1.1 — FKBP immunophilin/proline isomerase
Domain ID domain_idd1b6ch_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (12 domains)

Domain ID domain_id1b6cA00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
Domain ID domain_id1b6cB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1b6cB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id1b6cC00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
Domain ID domain_id1b6cD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1b6cD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id1b6cE00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
Domain ID domain_id1b6cF01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1b6cF02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id1b6cG00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
Domain ID domain_id1b6cH01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1b6cH02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
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7. Citations (1)