Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein heterocomplex | Heteromer | Protein 3 | ERYTHROPOIETIN RECEPTOR × 2 （P19235） water × 3 | Consistent with protein count |
| UniProt name | EPO_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–166； UniProt 28–193 |
Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein heterocomplex | Heteromer | Protein 3 | ERYTHROPOIETIN × 1 （P01588） water × 3 | Consistent with protein count |
| UniProt name | EPOR_HUMAN |
| Isoform | — |
| PDB entities | 2 |
| Chains and sequence ranges | Author chain B； PDBConstruct 8–227； UniProt 31–250 Author chain C； PDBConstruct 8–227； UniProt 31–250 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 1eer |
| Deposition date deposition_date | 1998-07-24 |
| Structure title title | CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS |
| Keywords keywords | ;ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR, SIGNAL TRANSDUCTION, HEMATOPOIETIC CYTOKINE, CYTOKINE RECEPTOR CLASS 1, COMPLEX (CYTOKINE-RECEPTOR), COMPLEX (CYTOKINE-RECEPTOR) complex ;; COMPLEX (CYTOKINE/RECEPTOR) |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 29.45 Å |
| Rg (electron density) | 28.43 Å |
| Total Rg | 29.06 Å |
| Atom count | 4619 |
| Residues | 592 |
| Excluded volume | 82041 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | d1eera_ |
| Class class | a — All alpha proteins |
| Fold Fold fold | a.26 — 4-helical cytokines |
| Superfamily Superfamily superfamily | a.26.1 — 4-helical cytokines |
| Family Family family | a.26.1.2 — Short-chain cytokines |
| Domain ID domain_id | d1eerb1 |
| Class class | b — All beta proteins |
| Fold Fold fold | b.1 — Immunoglobulin-like beta-sandwich |
| Superfamily Superfamily superfamily | b.1.2 — Fibronectin type III |
| Family Family family | b.1.2.1 — Fibronectin type III |
| Domain ID domain_id | d1eerb2 |
| Class class | b — All beta proteins |
| Fold Fold fold | b.1 — Immunoglobulin-like beta-sandwich |
| Superfamily Superfamily superfamily | b.1.2 — Fibronectin type III |
| Family Family family | b.1.2.1 — Fibronectin type III |
| Domain ID domain_id | d1eerc1 |
| Class class | b — All beta proteins |
| Fold Fold fold | b.1 — Immunoglobulin-like beta-sandwich |
| Superfamily Superfamily superfamily | b.1.2 — Fibronectin type III |
| Family Family family | b.1.2.1 — Fibronectin type III |
| Domain ID domain_id | d1eerc2 |
| Class class | b — All beta proteins |
| Fold Fold fold | b.1 — Immunoglobulin-like beta-sandwich |
| Superfamily Superfamily superfamily | b.1.2 — Fibronectin type III |
| Family Family family | b.1.2.1 — Fibronectin type III |
| Domain ID domain_id | 1eerA00 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 20 — Up-down Bundle |
| Topology topology | 1250 — Growth Hormone; Chain: A; |
| Homologous superfamily homologous superfamily | 10 — |
| Domain ID domain_id | 1eerB01 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 60 — Sandwich |
| Topology topology | 40 — Immunoglobulin-like |
| Homologous superfamily homologous superfamily | 10 — Immunoglobulins |
| Domain ID domain_id | 1eerB02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 60 — Sandwich |
| Topology topology | 40 — Immunoglobulin-like |
| Homologous superfamily homologous superfamily | 10 — Immunoglobulins |
| Domain ID domain_id | 1eerC01 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 60 — Sandwich |
| Topology topology | 40 — Immunoglobulin-like |
| Homologous superfamily homologous superfamily | 10 — Immunoglobulins |
| Domain ID domain_id | 1eerC02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 60 — Sandwich |
| Topology topology | 40 — Immunoglobulin-like |
| Homologous superfamily homologous superfamily | 10 — Immunoglobulins |