SAXSdb — 1f45

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1. Structure Basics

entry_id	1f45
deposition_date	2000-06-07
title	HUMAN INTERLEUKIN-12
keywords	interleukin, cytokine, CYTOKINE-CYTOKINE COMPLEX; CYTOKINE/CYTOKINE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.29 Å
rg_electron	28.13 Å
i0	37114900.00
molecular_weight	47457.0 kDa
excluded_volume	59439 Å³
envelope_volume	77401 Å³
shell_volume	24653 Å³
envelope_diameter	106.7 Å
shell_rg	32.75 Å
envelope_rg	28.38 Å
shape_rg	28.09 Å
total_rg	28.77 Å
total_atoms	3327
n_residues	415
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	102.1 Å
rg_real	30.02 Å
rg_real_error	0.41 Å
i0_real	3.7370e+07
i0_real_error	4.8120e+05
rg_reciprocal	28.46 Å
i0_reciprocal	37110000.0000
total_estimate	0.6205
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	27.4 Å
skewness	0.576
kurtosis	-0.207
angular_range	— – 0.2800 Å⁻¹
current_alpha	3.7750
highest_alpha	6002000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.775; Stabil: 0.863; Sysdev: 0.000; Positv: 1.000; Valcen: 0.657; Smooth: 0.548

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	INTERLEUKIN-12 BETA CHAIN
formula_weight	34739.9 kDa
mutation	A150F/A151N
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3348

IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Cricetulus griseus

Entity 2 polymer

description	INTERLEUKIN-12 ALPHA CHAIN
formula_weight	22568.2 kDa
mutation	T191M
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

RNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Cricetulus griseus

Entity 3 branched

description	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	586.5 kDa
src_method	man
entity_count	1

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	21

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6. Citations (1)

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length_a	112.900 Å
length_b	154.200 Å
length_c	101.700 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 2 2 21
int_tables_number	20
crystal_system	—

resolution	2.800 Å
resolution_low	12.000 Å
r_factor	0.2410
r_work	0.2410
r_free	0.2840

fit	/app/data/saxs_computation/f4/1f45/1f45.fit
pddf	/app/data/pr_computation/f4/1f45/1f45.pr.out
profile	/app/data/saxs_computation/f4/1f45/1f45.dat

HUMAN INTERLEUKIN-12

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 branched

Entity 4 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)