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1fbv

STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

SIGNAL TRANSDUCTION PROTEIN CBL

Homo sapiens

UniProt P22681

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 ZAP-70 PEPTIDE × 1 UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7 × 1 （P68036） ZINC ION × 2 SULFATE ION × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2juj 2k4d 2y1m 2y1m 2y1m 2y1m 2y1m 2y1m 3bum 3bun 3buw 3buw

24 assemblies; showing the first 12

Homodimer
2oo9 2oo9

2 assemblies

Homotetramer

None

Other homooligomers
1b47

1 assemblies

Heteromeric or nucleic-acid complex
1fbv 1yvh 2cbl 2y1n 2y1n 3bum 3bun 3buo 3buo 3buw 3buw 3bux

34 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CBL_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–388； UniProt 47–434

UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7

Homo sapiens

UniProt P68036

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 SIGNAL TRANSDUCTION PROTEIN CBL × 1 （P22681） ZAP-70 PEPTIDE × 1 ZINC ION × 2 SULFATE ION × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6xxu

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1c4z 1fbv 3sqv 3sqv 3sqv 3sy2 3sy2 4q5e 4q5h 5hpt 5hpt 5tte

26 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name UB2L3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–154； UniProt 1–154

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1fbv
Deposition date deposition_date2000-07-17
Structure title titleSTRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Keywords keywordscbl, ubch7, ZAP-70, E2, ubiquitin, E3, phosphorylation, tyrosine kinase, ubiquitination, protein degradation, LIGASE; LIGASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1fbv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1fbv__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1fbv__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.62 Å
Rg (electron density)27.03 Å
Total Rg27.53 Å
Atom count4393
Residues540
Excluded volume78562 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1fbv__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd1fbva1
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.7 — EF-hand modules in multidomain proteins
Domain ID domain_idd1fbva2
Class classa — All alpha proteins
Fold Fold folda.48 — N-cbl like
Superfamily Superfamily superfamilya.48.1 — N-terminal domain of cbl (N-cbl)
Family Family familya.48.1.1 — N-terminal domain of cbl (N-cbl)
Domain ID domain_idd1fbva3
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.93 — SH2-like
Superfamily Superfamily superfamilyd.93.1 — SH2 domain
Family Family familyd.93.1.1 — SH2 domain
Domain ID domain_idd1fbva4
Class classg — Small proteins
Fold Fold foldg.44 — RING/U-box
Superfamily Superfamily superfamilyg.44.1 — RING/U-box
Family Family familyg.44.1.1 — RING finger domain, C3HC4
Domain ID domain_idd1fbvc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.20 — UBC-like
Superfamily Superfamily superfamilyd.20.1 — UBC-like
Family Family familyd.20.1.1 — UBC-related

CATH v4.4 (5 domains)

Domain ID domain_id1fbvA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id1fbvA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology40 — Herpes Virus-1
Homologous superfamily homologous superfamily10 — Zinc/RING finger domain, C3HC4 (zinc finger)
Domain ID domain_id1fbvA03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology505 — SHC Adaptor Protein
Homologous superfamily homologous superfamily10 — SH2 domain
Domain ID domain_id1fbvA04
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology930 — Transcription Elongation Factor S-II; Chain A
Homologous superfamily homologous superfamily20 — Adaptor protein Cbl, N-terminal domain
Domain ID domain_id1fbvC00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology110 — Ubiquitin Conjugating Enzyme
Homologous superfamily homologous superfamily10 — Ubiquitin Conjugating Enzyme
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7. Citations (1)