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3buo

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

13-meric peptide from Epidermal growth factor receptor

OrganismNot specified

UniProt P00533

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 E3 ubiquitin-protein ligase CBL × 1 （P22681） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 E3 ubiquitin-protein ligase CBL × 1 （P22681） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1m14 1m17 1xkk 1z9i 2itn 2ito 2itp 2itq 2itt 2itu 2itv 2itw

358 assemblies; showing the first 12

Homodimer
2eb2 2eb3 2gs2 2gs7 2m0b 2m20 3gop 3gt8 3ika 3ug1 3ug2 3vjn

91 assemblies; showing the first 12

Homotetramer
5gty 5gty

2 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ivo 1mox 1yy9 2ks1 2rf9 2rf9 2rfd 2rfd 2rfe 2rfe 3b2u 3b2u

115 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EGFR_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–13； UniProt 1063–1075 Author chain C； PDBConstruct 1–13； UniProt 1063–1075

E3 ubiquitin-protein ligase CBL

Homo sapiens

UniProt P22681

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 13-meric peptide from Epidermal growth factor receptor × 1 （P00533） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 13-meric peptide from Epidermal growth factor receptor × 1 （P00533） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2juj 2k4d 2y1m 2y1m 2y1m 2y1m 2y1m 2y1m 3bum 3bun 3buw 3buw

24 assemblies; showing the first 12

Homodimer
2oo9 2oo9

2 assemblies

Homotetramer

None

Other homooligomers
1b47

1 assemblies

Heteromeric or nucleic-acid complex
1fbv 1yvh 2cbl 2y1n 2y1n 3bum 3bun 3buo 3buo 3buw 3buw 3bux

34 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CBL_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–329； UniProt 23–351 Author chain D； PDBConstruct 1–329； UniProt 23–351

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3buo
Deposition date deposition_date2008-01-03
Structure title titleCrystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Keywords keywords;Cbl, TKB, ligase, signal transduction, proto-oncogene, complex, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Metal-binding, SH2 domain, Ubl conjugation pathway, Zinc-finger, LIGASE-SIGNALING PROTEIN COMPLEX ;; LIGASE/SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3buo__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3buo__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3buo__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.46 Å
Rg (electron density)20.35 Å
Total Rg21.23 Å
Atom count2585
Residues314
Excluded volume46371 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3buo__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3buo__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd3buob1
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.7 — EF-hand modules in multidomain proteins
Domain ID domain_idd3buob2
Class classa — All alpha proteins
Fold Fold folda.48 — N-cbl like
Superfamily Superfamily superfamilya.48.1 — N-terminal domain of cbl (N-cbl)
Family Family familya.48.1.1 — N-terminal domain of cbl (N-cbl)
Domain ID domain_idd3buob3
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.93 — SH2-like
Superfamily Superfamily superfamilyd.93.1 — SH2 domain
Family Family familyd.93.1.1 — SH2 domain
Domain ID domain_idd3buod1
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.7 — EF-hand modules in multidomain proteins
Domain ID domain_idd3buod2
Class classa — All alpha proteins
Fold Fold folda.48 — N-cbl like
Superfamily Superfamily superfamilya.48.1 — N-terminal domain of cbl (N-cbl)
Family Family familya.48.1.1 — N-terminal domain of cbl (N-cbl)
Domain ID domain_idd3buod3
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.93 — SH2-like
Superfamily Superfamily superfamilyd.93.1 — SH2 domain
Family Family familyd.93.1.1 — SH2 domain

CATH v4.4 (6 domains)

Domain ID domain_id3buoB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology930 — Transcription Elongation Factor S-II; Chain A
Homologous superfamily homologous superfamily20 — Adaptor protein Cbl, N-terminal domain
Domain ID domain_id3buoB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id3buoB03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology505 — SHC Adaptor Protein
Homologous superfamily homologous superfamily10 — SH2 domain
Domain ID domain_id3buoD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology930 — Transcription Elongation Factor S-II; Chain A
Homologous superfamily homologous superfamily20 — Adaptor protein Cbl, N-terminal domain
Domain ID domain_id3buoD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id3buoD03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology505 — SHC Adaptor Protein
Homologous superfamily homologous superfamily10 — SH2 domain
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7. Citations (1)