物种未注明
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白异源复合物 | 异源复合物 | 蛋白 2 | E3 ubiquitin-protein ligase CBL × 1 （P22681） water × 2 | 与蛋白数一致 |
| 2 | 蛋白异源复合物 | 异源复合物 | 蛋白 2 | E3 ubiquitin-protein ligase CBL × 1 （P22681） water × 2 | 与蛋白数一致 |
| UniProt名称 | EGFR_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–13； UniProt 1063–1075 作者链 C； PDB构建体 1–13； UniProt 1063–1075 |
Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白异源复合物 | 异源复合物 | 蛋白 2 | 13-meric peptide from Epidermal growth factor receptor × 1 （P00533） water × 2 | 与蛋白数一致 |
| 2 | 蛋白异源复合物 | 异源复合物 | 蛋白 2 | 13-meric peptide from Epidermal growth factor receptor × 1 （P00533） water × 2 | 与蛋白数一致 |
| UniProt名称 | CBL_HUMAN |
| Isoform | — |
| PDB实体 | 2 |
| 链与序列区间 | 作者链 B； PDB构建体 1–329； UniProt 23–351 作者链 D； PDB构建体 1–329； UniProt 23–351 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 3buo |
| 沉积日期 deposition_date | 2008-01-03 |
| 结构标题 title | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' |
| 关键词 keywords | ;Cbl, TKB, ligase, signal transduction, proto-oncogene, complex, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Metal-binding, SH2 domain, Ubl conjugation pathway, Zinc-finger, LIGASE-SIGNALING PROTEIN COMPLEX ;; LIGASE/SIGNALING PROTEIN |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 21.46 Å |
| Rg（电子密度） | 20.35 Å |
| 总 Rg | 21.23 Å |
| 原子数 | 2585 |
| 残基数 | 314 |
| 排除体积 | 46371 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d3buob1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.39 — EF Hand-like |
| 超家族 Superfamily superfamily | a.39.1 — EF-hand |
| 家族 Family family | a.39.1.7 — EF-hand modules in multidomain proteins |
| 结构域编号 domain_id | d3buob2 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.48 — N-cbl like |
| 超家族 Superfamily superfamily | a.48.1 — N-terminal domain of cbl (N-cbl) |
| 家族 Family family | a.48.1.1 — N-terminal domain of cbl (N-cbl) |
| 结构域编号 domain_id | d3buob3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.93 — SH2-like |
| 超家族 Superfamily superfamily | d.93.1 — SH2 domain |
| 家族 Family family | d.93.1.1 — SH2 domain |
| 结构域编号 domain_id | d3buod1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.39 — EF Hand-like |
| 超家族 Superfamily superfamily | a.39.1 — EF-hand |
| 家族 Family family | a.39.1.7 — EF-hand modules in multidomain proteins |
| 结构域编号 domain_id | d3buod2 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.48 — N-cbl like |
| 超家族 Superfamily superfamily | a.48.1 — N-terminal domain of cbl (N-cbl) |
| 家族 Family family | a.48.1.1 — N-terminal domain of cbl (N-cbl) |
| 结构域编号 domain_id | d3buod3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.93 — SH2-like |
| 超家族 Superfamily superfamily | d.93.1 — SH2 domain |
| 家族 Family family | d.93.1.1 — SH2 domain |
| 结构域编号 domain_id | 3buoB01 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 20 — Up-down Bundle |
| 拓扑 Topology topology | 930 — Transcription Elongation Factor S-II; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 20 — Adaptor protein Cbl, N-terminal domain |
| 结构域编号 domain_id | 3buoB02 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 238 — Recoverin; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — EF-hand |
| 结构域编号 domain_id | 3buoB03 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 505 — SHC Adaptor Protein |
| 同源超家族 H-superfamily homologous superfamily | 10 — SH2 domain |
| 结构域编号 domain_id | 3buoD01 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 20 — Up-down Bundle |
| 拓扑 Topology topology | 930 — Transcription Elongation Factor S-II; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 20 — Adaptor protein Cbl, N-terminal domain |
| 结构域编号 domain_id | 3buoD02 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 238 — Recoverin; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — EF-hand |
| 结构域编号 domain_id | 3buoD03 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 505 — SHC Adaptor Protein |
| 同源超家族 H-superfamily homologous superfamily | 10 — SH2 domain |