1gmo

;CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR ;

Method: X-RAY DIFFRACTION Dmax: 124.2 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 1gmo

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1gmo
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1gmo
沉积日期 deposition_date2001-09-20
结构标题 title;CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR ;
关键词 keywordsHORMONE, GROWTH FACTOR; HORMONE
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier41.92
回转半径 Rg (电子) rg_electron41.04
零角强度 I(0) i0486351000.00
分子量 molecular_weight164130.0 kDa
排除体积 excluded_volume198070 ų
包络体积 envelope_volume295880 ų
水化壳体积 shell_volume58777 ų
包络直径 envelope_diameter127.6
壳层 Rg shell_rg48.66
包络 Rg envelope_rg39.14
形状 Rg shape_rg40.99
总 Rg total_rg41.56
总原子数 total_atoms11372
残基数 n_residues1377
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax124.2
Rg (实空间) rg_real41.63
Rg 误差 (实空间) rg_real_error0.69
I(0) (实空间) i0_real4.8640e+08
I(0) 误差 (实空间) i0_real_error7.6980e+06
Rg (倒空间) rg_reciprocal41.92
I(0) (倒空间) i0_reciprocal486500000.0000
解质量估计 total_estimate0.8927
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks1
主峰位置 r_peak_primary65.4
偏度 Skewness skewness-0.128
峰度 Kurtosis kurtosis-0.688
角度范围 angular_range— – 0.1900 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha40770000.0000
实空间数据点数 n_real_points39
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.897; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.985; Smooth: 0.927

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (9)

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd1gmoa1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmoa2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmob1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmob2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmoc1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmoc2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmod1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmod2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmoe1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmoe2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmof1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmof2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmog1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmog2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules
结构域编号 domain_idd1gmoh1
类 Class classg — Small proteins
折叠类型 Fold foldg.10 — Hairpin loop containing domain-like
超家族 Superfamily superfamilyg.10.1 — Hairpin loop containing domain-like
家族 Family familyg.10.1.1 — Hairpin loop containing domain
结构域编号 domain_idd1gmoh2
类 Class classg — Small proteins
折叠类型 Fold foldg.14 — Kringle-like
超家族 Superfamily superfamilyg.14.1 — Kringle-like
家族 Family familyg.14.1.1 — Kringle modules

CATH v4.4 (16 domains)

结构域编号 domain_id1gmoA01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoA02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoB01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoB02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoC01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoC02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoD01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoD02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoE01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoE02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoF01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoF02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoG01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoG02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4
结构域编号 domain_id1gmoH01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology4 — Hepatocyte Growth Factor
同源超家族 H-superfamily homologous superfamily10 — Hepatocyte Growth Factor
结构域编号 domain_id1gmoH02
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology20 — Plasminogen Kringle 4
同源超家族 H-superfamily homologous superfamily10 — Plasminogen Kringle 4

7. 引用文献 (1)

8. 文件与曲线 (10)