1htl

;MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS ;

Method: X-RAY DIFFRACTION Dmax: 86.5 Å Quality: EXCELLENT

SAXS 散射曲线 SAXS Profile

SAXS profile for 1htl

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1htl
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1htl
沉积日期 deposition_date1995-02-15
结构标题 title;MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS ;
关键词 keywordsENTEROTOXIN; ENTEROTOXIN
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier28.29
回转半径 Rg (电子) rg_electron26.95
零角强度 I(0) i0120368000.00
分子量 molecular_weight85242.0 kDa
排除体积 excluded_volume106270 ų
包络体积 envelope_volume127250 ų
水化壳体积 shell_volume38290 ų
包络直径 envelope_diameter91.6
壳层 Rg shell_rg35.20
包络 Rg envelope_rg26.97
形状 Rg shape_rg26.98
总 Rg total_rg27.64
总原子数 total_atoms5980
残基数 n_residues741
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax86.5
Rg (实空间) rg_real28.10
Rg 误差 (实空间) rg_real_error0.44
I(0) (实空间) i0_real1.2040e+08
I(0) 误差 (实空间) i0_real_error1.5820e+06
Rg (倒空间) rg_reciprocal28.16
I(0) (倒空间) i0_reciprocal120400000.0000
解质量估计 total_estimate0.9066
解质量评级 solution_quality EXCELLENT a EXCELLENT solution
P(r) 峰数 n_peaks2
主峰位置 r_peak_primary37.1
偏度 Skewness skewness0.133
峰度 Kurtosis kurtosis-0.545
角度范围 angular_range— – 0.2800 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha61080000.0000
实空间数据点数 n_real_points57
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.946; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.950

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (4)

6. 折叠分类 (SCOP + CATH) 13 domains

SCOP 2.08 (6 domains)

结构域编号 domain_idd1htl.1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.166 — ADP-ribosylation
超家族 Superfamily superfamilyd.166.1 — ADP-ribosylation
家族 Family familyd.166.1.1 — ADP-ribosylating toxins
结构域编号 domain_idd1htld_
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.2 — Bacterial enterotoxins
家族 Family familyb.40.2.1 — Bacterial AB5 toxins, B-subunits
结构域编号 domain_idd1htle_
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.2 — Bacterial enterotoxins
家族 Family familyb.40.2.1 — Bacterial AB5 toxins, B-subunits
结构域编号 domain_idd1htlf_
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.2 — Bacterial enterotoxins
家族 Family familyb.40.2.1 — Bacterial AB5 toxins, B-subunits
结构域编号 domain_idd1htlg_
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.2 — Bacterial enterotoxins
家族 Family familyb.40.2.1 — Bacterial AB5 toxins, B-subunits
结构域编号 domain_idd1htlh_
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.2 — Bacterial enterotoxins
家族 Family familyb.40.2.1 — Bacterial AB5 toxins, B-subunits

CATH v4.4 (7 domains)

结构域编号 domain_id1htlA00
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology210 — Heat-Labile Enterotoxin; Chain A
同源超家族 H-superfamily homologous superfamily10 — Heat-Labile Enterotoxin, subunit A
结构域编号 domain_id1htlC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily240
结构域编号 domain_id1htlD00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily110
结构域编号 domain_id1htlE00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily110
结构域编号 domain_id1htlF00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily110
结构域编号 domain_id1htlG00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily110
结构域编号 domain_id1htlH00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily110

7. 引用文献 (4)

8. 文件与曲线 (10)