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1k6o

Crystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ETS-domain protein ELK-4

Homo sapiens

UniProt P28324

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 5'-D(*CP*AP*CP*AP*GP*GP*AP*TP*GP*TP*CP*CP*AP*TP*AP*TP*TP*AP*GP*GP*AP*CP*A)-3' × 1 5'-D(*TP*GP*TP*CP*CP*TP*AP*AP*TP*AP*TP*GP*GP*AP*CP*AP*TP*CP*CP*TP*GP*TP*G)-3' × 1 Serum response factor × 2 （P11831） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bc7 1bc8 1hbx 1hbx 1k6o

5 assemblies

View Construct and Data Evidence
UniProt name ELK4_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–93； UniProt 1–93

Serum response factor

Homo sapiens

UniProt P11831

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 5'-D(*CP*AP*CP*AP*GP*GP*AP*TP*GP*TP*CP*CP*AP*TP*AP*TP*TP*AP*GP*GP*AP*CP*A)-3' × 1 5'-D(*TP*GP*TP*CP*CP*TP*AP*AP*TP*AP*TP*GP*GP*AP*CP*AP*TP*CP*CP*TP*GP*TP*G)-3' × 1 ETS-domain protein ELK-4 × 1 （P28324） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1hbx 1hbx 1k6o 1srs

4 assemblies

View Construct and Data Evidence
UniProt name SRF_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B； PDBConstruct 1–103； UniProt 133–235 Author chain C； PDBConstruct 1–103； UniProt 133–235

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1k6o
Deposition date deposition_date2001-10-16
Structure title titleCrystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex
Keywords keywords;PROTEIN-DNA COMPLEX, TRANSCRIPTION FACTOR, COMBINATORIAL GENE REGULATION, ETS PROTEINS, MADS-BOX PROTEINS, TRANSCRIPTION-DNA COMPLEX ;; TRANSCRIPTION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1k6o__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1k6o__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1k6o__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.55 Å
Rg (electron density)24.32 Å
Total Rg24.93 Å
Atom count2957
Residues304
Excluded volume50316 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1k6o__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

Domain ID domain_idd1k6oa_
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.5 — 'Winged helix' DNA-binding domain
Family Family familya.4.5.21 — ets domain
Domain ID domain_idd1k6ob_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.88 — SRF-like
Superfamily Superfamily superfamilyd.88.1 — SRF-like
Family Family familyd.88.1.1 — SRF-like
Domain ID domain_idd1k6oc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.88 — SRF-like
Superfamily Superfamily superfamilyd.88.1 — SRF-like
Family Family familyd.88.1.1 — SRF-like

CATH v4.4 (3 domains)

Domain ID domain_id1k6oA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Domain ID domain_id1k6oB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id1k6oC01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
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7. Citations (1)