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1kat

Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Vascular Endothelial Growth Factor

Homo sapiens

UniProt P15692

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Phage-Derived Peptide Antagonist × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1kmx 1vgh 2vgh

3 assemblies

Homodimer
1mjv 1mkg 1mkg 1mkk 1vpf 1vpf 2vpf 2vpf 2vpf 2vpf 3bdy 3qtk

15 assemblies; showing the first 12

Homotetramer
1mkg

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bj1 1cz8 1flt 1flt 1kat 1qty 1qty 1qty 1tzh 1tzi 1vpp 2qr0

54 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name VEGFA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain V； PDBConstruct 1–99； UniProt 37–135 Author chain W； PDBConstruct 1–99； UniProt 37–135

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1kat
Deposition date deposition_date2001-11-02
Structure title titleSolution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
Keywords keywordsProtein-peptide complex, homodimer, cystine knot, CELL CYCLE, HORMONE-GROWTH FACTOR COMPLEX; CELL CYCLE, HORMONE/GROWTH FACTOR
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1kat__assembly_1__model_21

Assembly 1 · Model 21 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1kat__assembly_1__model_21 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1kat__assembly_1__model_21 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.63 Å
Rg (electron density)21.76 Å
Total Rg22.39 Å
Atom count3756
Residues236
Excluded volume34184 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1kat__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 1kat__assembly_1__model_2 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 1kat__assembly_1__model_3 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 1kat__assembly_1__model_4 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 1kat__assembly_1__model_5 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 1kat__assembly_1__model_6 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 1kat__assembly_1__model_7 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 1kat__assembly_1__model_8 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 1kat__assembly_1__model_9 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 1kat__assembly_1__model_10 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 1kat__assembly_1__model_11 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 1kat__assembly_1__model_12 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 1kat__assembly_1__model_13 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 1kat__assembly_1__model_14 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 1kat__assembly_1__model_15 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 1kat__assembly_1__model_16 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 1kat__assembly_1__model_17 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 1kat__assembly_1__model_18 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 1kat__assembly_1__model_19 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 1kat__assembly_1__model_20 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 1kat__assembly_1__model_21 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 1kat__assembly_1__model_22 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 1kat__assembly_1__model_23 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 1kat__assembly_1__model_24 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1katv_
Class classg — Small proteins
Fold Fold foldg.17 — Cystine-knot cytokines
Superfamily Superfamily superfamilyg.17.1 — Cystine-knot cytokines
Family Family familyg.17.1.1 — Platelet-derived growth factor-like
Domain ID domain_idd1katw_
Class classg — Small proteins
Fold Fold foldg.17 — Cystine-knot cytokines
Superfamily Superfamily superfamilyg.17.1 — Cystine-knot cytokines
Family Family familyg.17.1.1 — Platelet-derived growth factor-like

CATH v4.4 (2 domains)

Domain ID domain_id1katV00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology90 — Cystine Knot Cytokines, subunit B
Homologous superfamily homologous superfamily10 — Cystine-knot cytokines
Domain ID domain_id1katW00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology90 — Cystine Knot Cytokines, subunit B
Homologous superfamily homologous superfamily10 — Cystine-knot cytokines
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7. Citations (1)