1n4q

Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide

Method: X-RAY DIFFRACTION Dmax: 237.5 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 1n4q

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1n4q
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1n4q
沉积日期 deposition_date2002-11-01
结构标题 titleProtein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide
关键词 keywordsprotein geranylgeranyltransferase type-I, GGTase, geranylgeranyl, protein prenylation, CaaX, lipid modification, rap2b, TRANSFERASE; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier65.26
回转半径 Rg (电子) rg_electron65.29
零角强度 I(0) i02992010000.00
分子量 molecular_weight460760.0 kDa
排除体积 excluded_volume575120 ų
包络体积 envelope_volume806980 ų
水化壳体积 shell_volume102930 ų
包络直径 envelope_diameter223.3
壳层 Rg shell_rg65.59
包络 Rg envelope_rg63.67
形状 Rg shape_rg65.29
总 Rg total_rg65.28
总原子数 total_atoms32429
残基数 n_residues3990
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax237.5
Rg (实空间) rg_real65.34
Rg 误差 (实空间) rg_real_error2.46
I(0) (实空间) i0_real2.9920e+09
I(0) 误差 (实空间) i0_real_error6.6310e+07
Rg (倒空间) rg_reciprocal65.16
I(0) (倒空间) i0_reciprocal2991000000.0000
解质量估计 total_estimate0.8530
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks2
主峰位置 r_peak_primary99.0
偏度 Skewness skewness0.230
峰度 Kurtosis kurtosis-0.498
角度范围 angular_range— – 0.1200 −1
当前正则化参数 α current_alpha0.0044
最高正则化参数 α highest_alpha134100000.0000
实空间数据点数 n_real_points25
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.743; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.973; Smooth: 0.883

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (8)

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

结构域编号 domain_idd1n4qa_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4qb_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases
结构域编号 domain_idd1n4qc_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4qd_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases
结构域编号 domain_idd1n4qe_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4qf_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases
结构域编号 domain_idd1n4qg_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4qh_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases
结构域编号 domain_idd1n4qi_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4qj_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases
结构域编号 domain_idd1n4qk_
类 Class classa — All alpha proteins
折叠类型 Fold folda.118 — alpha-alpha superhelix
超家族 Superfamily superfamilya.118.6 — Protein prenylyltransferase
家族 Family familya.118.6.1 — Protein prenylyltransferase
结构域编号 domain_idd1n4ql_
类 Class classa — All alpha proteins
折叠类型 Fold folda.102 — alpha/alpha toroid
超家族 Superfamily superfamilya.102.4 — Terpenoid cyclases/Protein prenyltransferases
家族 Family familya.102.4.3 — Protein prenyltransferases

CATH v4.4 (12 domains)

结构域编号 domain_id1n4qA00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qB00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20
结构域编号 domain_id1n4qC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20
结构域编号 domain_id1n4qE00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qF00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20
结构域编号 domain_id1n4qG00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20
结构域编号 domain_id1n4qI00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qJ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20
结构域编号 domain_id1n4qK00
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily120 — Protein prenylyltransferase
结构域编号 domain_id1n4qL00
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20

7. 引用文献 (1)

8. 文件与曲线 (10)