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1n6j

Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Myocyte-specific enhancer factor 2B

Homo sapiens

UniProt Q02080

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3' × 1 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3' × 1 Calcineurin-binding protein Cabin 1 × 1 （Q9Y6J0） water × 5 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
6c9l 6c9l 6c9l

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1n6j 1tqe 1tqe 6byy 6byy 6bz1 6bz1 6wc2 6wc2 6wc2 6wc5 6wc5

12 assemblies

View Construct and Data Evidence
UniProt name MEF2B_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–93； UniProt 2–94 Author chain B； PDBConstruct 1–93； UniProt 2–94

Calcineurin-binding protein Cabin 1

Homo sapiens

UniProt Q9Y6J0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3' × 1 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3' × 1 Myocyte-specific enhancer factor 2B × 2 （Q02080） water × 5 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1n6j

1 assemblies

View Construct and Data Evidence
UniProt name CABIN_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain G； PDBConstruct 1–35； UniProt 2156–2190

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1n6j
Deposition date deposition_date2002-11-11
Structure title titleStructural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2
Keywords keywordsMADS-box, Protein-DNA complex, histone deacetylases, TRANSCRIPTION-DNA COMPLEX; TRANSCRIPTION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1n6j__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1n6j__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1n6j__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.42 Å
Rg (electron density)19.09 Å
Total Rg19.98 Å
Atom count2273
Residues237
Excluded volume38896 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1n6j__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 1n6j__assembly_1__model_2 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1n6ja_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.88 — SRF-like
Superfamily Superfamily superfamilyd.88.1 — SRF-like
Family Family familyd.88.1.1 — SRF-like
Domain ID domain_idd1n6jb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.88 — SRF-like
Superfamily Superfamily superfamilyd.88.1 — SRF-like
Family Family familyd.88.1.1 — SRF-like

CATH v4.4 (2 domains)

Domain ID domain_id1n6jA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id1n6jB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
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7. Citations (1)