1rer

Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Structural polyprotein

物种未注明

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	其他组合	同源多聚体	蛋白 3 其他聚合物 3	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 BROMIDE ION × 3 HOLMIUM ATOM × 4 PHOSPHATE ION × 1 water × 3	与蛋白数一致
2	其他组合	同源多聚体	蛋白 6 其他聚合物 6	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 BROMIDE ION × 6 HOLMIUM ATOM × 8 PHOSPHATE ION × 2 water × 6	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	POLS_SFV
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–391； UniProt 816–1206 作者链 B； PDB构建体 1–391； UniProt 816–1206 作者链 C； PDB构建体 1–391； UniProt 816–1206

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1rer
沉积日期 deposition_date	2003-11-07
结构标题 title	Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.
关键词 keywords	Envelope glycoprotein, Membrane fusion, virus., Viral protein; VIRAL PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1rer__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1rer__assembly_2__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1rer__assembly_2__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	56.69 Å
Rg（电子密度）	57.08 Å
总 Rg	57.13 Å
原子数	18356
残基数	2346
排除体积	325940 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1rer__assembly_1__model_1`	trimeric （3）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`1rer__assembly_2__model_1`	hexameric （6）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (8)

实体 1 Entity 1 polymer

描述 description	Structural polyprotein
分子量 formula_weight	42690.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C
原子数 atom_count	9317

YEHSTVMPNVVGFPYKAHIERPGYSPLTLQMQVVETSLEPTLNLEYITCEYKTVVPSPYVKCCGASECSTKEKPDYQCKVYTGVYPFMWGGAYCFCDSENTQLSEAYVDRSDVCRHDHASAYKAHTASLKAKVRVMYGNVNQTVDVYVNGDHAVTIGGTQFIFGPLSSAWTPFDNKIVVYKDEVFNQDFPPYGSGQPGRFGDIQSRTVESNDLYANTALKLARPSPGMVHVPYTQTPSGFKYWLKEKGTALNTKAPFGCQIKTNPVRAMNCAVGNIPVSMNLPDSAFTRIVEAPTIIDLTCTVATCTHSSDFGGVLTLTYKTNKNGDCSVHSHSNVATLQEATAKVKTAGKVTLHFSTASASPSFVVSLCSARATCSASCEPPKDHIVPYA

实体 2 Entity 2 branched

描述 description	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1098.0 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 3 Entity 3 branched

描述 description	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1260.2 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 4 Entity 4 branched

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	424.4 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 5 Entity 5 non-polymer

描述 description	BROMIDE ION
分子量 formula_weight	79.9 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 6 Entity 6 non-polymer

描述 description	HOLMIUM ATOM
分子量 formula_weight	164.9 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 7 Entity 7 non-polymer

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 8 Entity 8 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	139

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6. 折叠分类 (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

结构域编号 domain_id	d1rera1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.18 — E set domains
家族 Family family	b.1.18.4 — Class II viral fusion proteins C-terminal domain

结构域编号 domain_id	d1rera2
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.10 — Viral glycoprotein, central and dimerisation domains
超家族 Superfamily superfamily	f.10.1 — Viral glycoprotein, central and dimerisation domains
家族 Family family	f.10.1.1 — Viral glycoprotein, central and dimerisation domains

结构域编号 domain_id	d1rerb1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.18 — E set domains
家族 Family family	b.1.18.4 — Class II viral fusion proteins C-terminal domain

结构域编号 domain_id	d1rerb2
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.10 — Viral glycoprotein, central and dimerisation domains
超家族 Superfamily superfamily	f.10.1 — Viral glycoprotein, central and dimerisation domains
家族 Family family	f.10.1.1 — Viral glycoprotein, central and dimerisation domains

结构域编号 domain_id	d1rerc1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.18 — E set domains
家族 Family family	b.1.18.4 — Class II viral fusion proteins C-terminal domain

结构域编号 domain_id	d1rerc2
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.10 — Viral glycoprotein, central and dimerisation domains
超家族 Superfamily superfamily	f.10.1 — Viral glycoprotein, central and dimerisation domains
家族 Family family	f.10.1.1 — Viral glycoprotein, central and dimerisation domains

CATH v4.4 (6 domains)

结构域编号 domain_id	1rerA01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
同源超家族 H-superfamily homologous superfamily	10 — Tick-borne Encephalitis virus Glycoprotein, domain 1

结构域编号 domain_id	1rerA03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	350 —

结构域编号 domain_id	1rerB01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
同源超家族 H-superfamily homologous superfamily	10 — Tick-borne Encephalitis virus Glycoprotein, domain 1

结构域编号 domain_id	1rerB03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	350 —

结构域编号 domain_id	1rerC01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
同源超家族 H-superfamily homologous superfamily	10 — Tick-borne Encephalitis virus Glycoprotein, domain 1

结构域编号 domain_id	1rerC03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	350 —

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晶胞边长 a length_a	198.197 Å
晶胞边长 b length_b	198.197 Å
晶胞边长 c length_c	116.250 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	18

空间群 space_group	P 31 2 1
空间群编号 int_tables_number	152
晶系 crystal_system	—

分辨率 resolution	3.200 Å
最低分辨率 resolution_low	20.000 Å
R 因子 r_factor	0.2660
R_work r_work	0.2650
R_free r_free	0.2850

Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Structural polyprotein

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1rer__assembly_2__model_1

1rer__assembly_2__model_1 | I(q)

1rer__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

5. 实体与聚合物信息 Entities & Polymers (8)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 water

6. 折叠分类 (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

CATH v4.4 (6 domains)

7. 引用文献 (4)

Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Structural polyprotein

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1rer__assembly_2__model_1

1rer__assembly_2__model_1 | I(q)

1rer__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

5. 实体与聚合物信息 Entities & Polymers (8)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 water

6. 折叠分类 (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

CATH v4.4 (6 domains)

7. 引用文献 (4)