1rqq

Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS

Method: X-RAY DIFFRACTION Dmax: 115.6 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 1rqq

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1rqq
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1rqq
沉积日期 deposition_date2003-12-06
结构标题 titleCrystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
关键词 keywordsProtein tyrosine kinase, adaptor protein, SH2 domain, TRANSFERASE-SIGNALING PROTEIN COMPLEX; TRANSFERASE/SIGNALING PROTEIN
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier34.09
回转半径 Rg (电子) rg_electron33.70
零角强度 I(0) i0130078000.00
分子量 molecular_weight88881.0 kDa
排除体积 excluded_volume110080 ų
包络体积 envelope_volume144920 ų
水化壳体积 shell_volume36790 ų
包络直径 envelope_diameter116.2
壳层 Rg shell_rg39.66
包络 Rg envelope_rg32.71
形状 Rg shape_rg33.70
总 Rg total_rg34.16
总原子数 total_atoms6221
残基数 n_residues781
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax115.6
Rg (实空间) rg_real34.20
Rg 误差 (实空间) rg_real_error1.28
I(0) (实空间) i0_real1.3010e+08
I(0) 误差 (实空间) i0_real_error2.3310e+06
Rg (倒空间) rg_reciprocal34.14
I(0) (倒空间) i0_reciprocal130100000.0000
解质量估计 total_estimate0.8022
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks2
主峰位置 r_peak_primary30.1
偏度 Skewness skewness0.364
峰度 Kurtosis kurtosis-0.555
角度范围 angular_range— – 0.2300 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha38770000.0000
实空间数据点数 n_real_points47
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.840; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.905; Smooth: 0.000

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (6)

6. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd1rqqa_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.144 — Protein kinase-like (PK-like)
超家族 Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
家族 Family familyd.144.1.7 — Protein kinases, catalytic subunit
结构域编号 domain_idd1rqqb_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.144 — Protein kinase-like (PK-like)
超家族 Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
家族 Family familyd.144.1.7 — Protein kinases, catalytic subunit
结构域编号 domain_idd1rqqc_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.93 — SH2-like
超家族 Superfamily superfamilyd.93.1 — SH2 domain
家族 Family familyd.93.1.1 — SH2 domain
结构域编号 domain_idd1rqqd_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.93 — SH2-like
超家族 Superfamily superfamilyd.93.1 — SH2 domain
家族 Family familyd.93.1.1 — SH2 domain

CATH v4.4 (6 domains)

结构域编号 domain_id1rqqA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology200 — Phosphorylase Kinase; domain 1
同源超家族 H-superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
结构域编号 domain_id1rqqA02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology510 — Transferase(Phosphotransferase); domain 1
同源超家族 H-superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
结构域编号 domain_id1rqqB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology200 — Phosphorylase Kinase; domain 1
同源超家族 H-superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
结构域编号 domain_id1rqqB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology510 — Transferase(Phosphotransferase); domain 1
同源超家族 H-superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
结构域编号 domain_id1rqqC00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology505 — SHC Adaptor Protein
同源超家族 H-superfamily homologous superfamily10 — SH2 domain
结构域编号 domain_id1rqqD00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology505 — SHC Adaptor Protein
同源超家族 H-superfamily homologous superfamily10 — SH2 domain

7. 引用文献 (1)

8. 文件与曲线 (10)