1vf7

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Multidrug resistance protein mexA

Pseudomonas aeruginosa

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 13	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MEXA_PSEAE
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 5–363； UniProt 25–383 Author chain B； PDBConstruct 5–363； UniProt 25–383 Author chain C； PDBConstruct 5–363； UniProt 25–383 Author chain D； PDBConstruct 5–363； UniProt 25–383 Author chain E； PDBConstruct 5–363； UniProt 25–383 Author chain F； PDBConstruct 5–363； UniProt 25–383 Author chain G； PDBConstruct 5–363； UniProt 25–383 Author chain H； PDBConstruct 5–363； UniProt 25–383 Author chain I； PDBConstruct 5–363； UniProt 25–383 Author chain J； PDBConstruct 5–363； UniProt 25–383 Author chain K； PDBConstruct 5–363； UniProt 25–383 Author chain L； PDBConstruct 5–363； UniProt 25–383 Author chain M； PDBConstruct 5–363； UniProt 25–383

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1vf7
Deposition date deposition_date	2004-04-09
Structure title title	Crystal structure of the membrane fusion protein, MexA of the multidrug transporter
Keywords keywords	alpha hairpin, beta barrel, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1vf7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1vf7__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1vf7__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	68.05 Å
Rg (electron density)	68.68 Å
Total Rg	68.47 Å
Atom count	23655
Residues	3085
Excluded volume	417960 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1vf7__assembly_1__model_1`	tridecameric （13）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

Domain ID domain_id	d1vf7a_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7b_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7c_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7d_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7e_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7f_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7g_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7h_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7i_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7j_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7k_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7l_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

Domain ID domain_id	d1vf7m_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.46 — HlyD-like secretion proteins
Superfamily Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
Family Family family	f.46.1.1 — HlyD-like secretion proteins

CATH v4.4 (39 domains)

Domain ID domain_id	1vf7A01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7A02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7A03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7B01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7B02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7B03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7C01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7C02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7C03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7D01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7D02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7D03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7E01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7E02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7E03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7F01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7F02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7F03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7G01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7G02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7G03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7H01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7H02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7H03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7I01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7I02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7I03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7J01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7J02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7J03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7K01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7K02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7K03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7L01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7L02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7L03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

Domain ID domain_id	1vf7M01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

Domain ID domain_id	1vf7M02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain ID domain_id	1vf7M03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	470 — Helix hairpin bin

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Unit-cell length a length_a	130.030 Å
Unit-cell length b length_b	180.350 Å
Unit-cell length c length_c	214.230 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	106.99 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	26

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.400 Å
Low-resolution limit resolution_low	40.000 Å
R factor r_factor	0.2590
R_work r_work	0.2580
R_free r_free	0.2822

Description description	Multidrug resistance protein mexA
Molecular weight formula_weight	39733.6 kDa
Source method src_method	man
Copy count entity_count	13

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M
Atom count atom_count	23655

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

1. Protein Identity and Related Structures Protein Identity & Related Structures

Multidrug resistance protein mexA

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1vf7__assembly_1__model_1

1vf7__assembly_1__model_1 | I(q)

1vf7__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

CATH v4.4 (39 domains)

7. Citations (1)

Source organism organism	Pseudomonas aeruginosa
NCBI taxonomy ID ncbi_taxonomy_id	287
Host organism host_organism	Pseudomonas aeruginosa

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

1. Protein Identity and Related Structures Protein Identity & Related Structures

Multidrug resistance protein mexA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1vf7__assembly_1__model_1

1vf7__assembly_1__model_1 | I(q)

1vf7__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

CATH v4.4 (39 domains)

7. Citations (1)