1vf7

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Multidrug resistance protein mexA

Pseudomonas aeruginosa

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 13	无其他共同聚合物	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	MEXA_PSEAE
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 5–363； UniProt 25–383 作者链 B； PDB构建体 5–363； UniProt 25–383 作者链 C； PDB构建体 5–363； UniProt 25–383 作者链 D； PDB构建体 5–363； UniProt 25–383 作者链 E； PDB构建体 5–363； UniProt 25–383 作者链 F； PDB构建体 5–363； UniProt 25–383 作者链 G； PDB构建体 5–363； UniProt 25–383 作者链 H； PDB构建体 5–363； UniProt 25–383 作者链 I； PDB构建体 5–363； UniProt 25–383 作者链 J； PDB构建体 5–363； UniProt 25–383 作者链 K； PDB构建体 5–363； UniProt 25–383 作者链 L； PDB构建体 5–363； UniProt 25–383 作者链 M； PDB构建体 5–363； UniProt 25–383

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1vf7
沉积日期 deposition_date	2004-04-09
结构标题 title	Crystal structure of the membrane fusion protein, MexA of the multidrug transporter
关键词 keywords	alpha hairpin, beta barrel, MEMBRANE PROTEIN; MEMBRANE PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1vf7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1vf7__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1vf7__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	68.05 Å
Rg（电子密度）	68.68 Å
总 Rg	68.47 Å
原子数	23655
残基数	3085
排除体积	417960 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1vf7__assembly_1__model_1`	tridecameric （13）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (1)

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6. 折叠分类 (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

结构域编号 domain_id	d1vf7a_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7b_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7c_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7d_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7e_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7f_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7g_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7h_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7i_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7j_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7k_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7l_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

结构域编号 domain_id	d1vf7m_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.46 — HlyD-like secretion proteins
超家族 Superfamily superfamily	f.46.1 — HlyD-like secretion proteins
家族 Family family	f.46.1.1 — HlyD-like secretion proteins

CATH v4.4 (39 domains)

结构域编号 domain_id	1vf7A01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7A02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7A03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7B01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7B02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7B03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7C01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7C02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7C03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7D01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7D02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7D03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7E01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7E02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7E03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7F01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7F02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7F03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7G01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7G02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7G03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7H01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7H02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7H03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7I01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7I02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7I03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7J01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7J02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7J03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7K01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7K02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7K03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7L01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7L02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7L03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	1vf7M01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	1vf7M02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	1vf7M03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

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晶胞边长 a length_a	130.030 Å
晶胞边长 b length_b	180.350 Å
晶胞边长 c length_c	214.230 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	106.99 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	26

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.400 Å
最低分辨率 resolution_low	40.000 Å
R 因子 r_factor	0.2590
R_work r_work	0.2580
R_free r_free	0.2822

描述 description	Multidrug resistance protein mexA
分子量 formula_weight	39733.6 kDa
来源方法 src_method	man
拷贝数 entity_count	13

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M
原子数 atom_count	23655

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Multidrug resistance protein mexA

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1vf7__assembly_1__model_1

1vf7__assembly_1__model_1 | I(q)

1vf7__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (1)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

6. 折叠分类 (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

CATH v4.4 (39 domains)

7. 引用文献 (1)

来源生物 organism	Pseudomonas aeruginosa
NCBI 分类编号 ncbi_taxonomy_id	287
宿主生物 host_organism	Pseudomonas aeruginosa

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Multidrug resistance protein mexA

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1vf7__assembly_1__model_1

1vf7__assembly_1__model_1 | I(q)

1vf7__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (1)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

6. 折叠分类 (SCOP + CATH) 52 domains

SCOP 2.08 (13 domains)

CATH v4.4 (39 domains)

7. 引用文献 (1)