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1xr0

Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Basic fibroblast growth factor receptor 1

OrganismNot specified

UniProt P11362

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 FGFR signalling adaptor SNT-1 × 1 （Q8WU20） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1agw 1agw 1fgi 1fgi 2cr3 3c4f 3c4f 3gql 3gql 3gql 3kxx 3kxx

122 assemblies; showing the first 12

Homodimer
1fgk 2fgi 3c4f 3gql 3js2 3js2 3kxx 3kxx 4f63 4f64 4f65 4nk9

14 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1cvs 1cvs 1evt 1fq9 1xr0 3dpk 3gqi 3krj 3krl 3ojv 3ojv 5w21

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FGFR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–22； UniProt 409–430

FGFR signalling adaptor SNT-1

Homo sapiens

UniProt Q8WU20

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Basic fibroblast growth factor receptor 1 × 1 （P11362） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1xr0 2mfq

2 assemblies

View Construct and Data Evidence
UniProt name FRS2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 4–129； UniProt 11–136

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1xr0
Deposition date deposition_date2004-10-13
Structure title titleStructural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Keywords keywordsFGFR, SNT, phosphotyrosine binding domain, PTB, TRK, NPXpY motif, SIGNALING PROTEIN-GROWTH FACTOR RECEPTOR COMPLEX; SIGNALING PROTEIN/GROWTH FACTOR RECEPTOR
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1xr0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1xr0__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1xr0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.39 Å
Rg (electron density)19.80 Å
Total Rg20.59 Å
Atom count2436
Residues151
Excluded volume21526 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1xr0__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1xr0b1
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.2 — Phosphotyrosine-binding domain (PTB)
Domain ID domain_idd1xr0b2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (1 domains)

Domain ID domain_id1xr0B01
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
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7. Citations (1)