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1agw

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR

Method: X-RAY DIFFRACTION D_max: 107.7 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1agw
deposition_date	1997-03-25
title	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
keywords	PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, INHIBITOR; PROTEIN KINASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	30.52 Å
rg_electron	30.54 Å
i0	59784400.00
molecular_weight	62220.0 kDa
excluded_volume	78576 Å³
envelope_volume	100530 Å³
shell_volume	29613 Å³
envelope_diameter	112.8 Å
shell_rg	34.53 Å
envelope_rg	30.83 Å
shape_rg	30.51 Å
total_rg	31.01 Å
total_atoms	4368
n_residues	550
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	107.7 Å
rg_real	30.90 Å
rg_real_error	1.12 Å
i0_real	5.9780e+07
i0_real_error	9.9890e+05
rg_reciprocal	30.74 Å
i0_reciprocal	59780000.0000
total_estimate	0.7946
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	26.9 Å
skewness	0.646
kurtosis	-0.067
angular_range	— – 0.2600 Å⁻¹
current_alpha	0.0000
highest_alpha	25790000.0000
n_real_points	53
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.640; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.620; Smooth: 0.786

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	FGF RECEPTOR 1
formula_weight	35308.6 kDa
ec_number	2.7.1.112
mutation	L457V, C488A, C584S
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	4607

MVAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 non-polymer

description	3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
formula_weight	335.4 kDa
src_method	syn
entity_count	2

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	234

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6. Citations (2)

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length_a	208.360 Å
length_b	57.080 Å
length_c	65.530 Å
angle_alpha	90.00 °
angle_beta	107.54 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 1 2 1
int_tables_number	5
crystal_system	—

resolution	2.400 Å
resolution_low	6.000 Å
r_factor	0.1940
r_work	0.1940
r_free	0.2800

fit	/app/data/saxs_computation/ag/1agw/1agw.fit
pddf	/app/data/pr_computation/ag/1agw/1agw.pr.out
profile	/app/data/saxs_computation/ag/1agw/1agw.dat

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction