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9vlj

Crystal structure of FGFR1 in complex with covalent inhibitor 10a

Method: X-RAY DIFFRACTION D_max: 100.5 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9vlj
deposition_date	2025-06-25
last_revision	2026-05-06
title	Crystal structure of FGFR1 in complex with covalent inhibitor 10a
keywords	FGFR1, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	29.58 Å
rg_electron	29.13 Å
i0	148579000.00
molecular_weight	63783.0 kDa
excluded_volume	61258 Å³
envelope_volume	109810 Å³
shell_volume	31520 Å³
envelope_diameter	104.7 Å
shell_rg	36.11 Å
envelope_rg	28.98 Å
shape_rg	29.15 Å
total_rg	29.59 Å
total_atoms	4792
n_residues	597
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	100.5 Å
rg_real	29.59 Å
rg_real_error	1.07 Å
i0_real	1.4860e+08
i0_real_error	2.3840e+06
rg_reciprocal	29.59 Å
i0_reciprocal	148600000.0000
total_estimate	0.8023
solution_quality	GOOD a GOOD solution
n_peaks	3
r_peak_primary	27.9 Å
skewness	0.275
kurtosis	-0.612
angular_range	— – 0.2700 Å⁻¹
current_alpha	0.0000
highest_alpha	46630000.0000
n_real_points	55
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.833; Stabil: 0.994; Sysdev: 1.000; Positv: 1.000; Valcen: 0.947; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Fibroblast growth factor receptor 1
formula_weight	35264.5 kDa
ec_number	2.7.10.1
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	5215

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	~{N}-[3-[2-[[3-[2-(dimethylamino)ethylsulfamoylmethyl]phenyl]amino]pyrimidin-4-yl]-1-methyl-indol-6-yl]propanamide
formula_weight	535.7 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	10

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	423

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6. Citations (1)

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length_a	211.440 Å
length_b	49.710 Å
length_c	66.840 Å
angle_alpha	90.00 °
angle_beta	107.75 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 1 2 1
int_tables_number	5
crystal_system	—

resolution	1.810 Å
resolution_low	31.600 Å
r_factor	0.1781
r_work	0.1762
r_free	0.2146

fit	/app/data/saxs_computation/vl/9vlj/9vlj.fit
pddf	/app/data/pr_computation/vl/9vlj/9vlj.pr.out
profile	/app/data/saxs_computation/vl/9vlj/9vlj.dat

Crystal structure of FGFR1 in complex with covalent inhibitor 10a

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction