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9u7g

FGFR1 kinase domain with a macrocyclic compound 8g

Method: X-RAY DIFFRACTION D_max: 98.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9u7g
deposition_date	2025-03-24
last_revision	2026-04-01
title	FGFR1 kinase domain with a macrocyclic compound 8g
keywords	Fibroblast growth factor receptor 1, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	29.50 Å
rg_electron	29.00 Å
i0	131860000.00
molecular_weight	60290.0 kDa
excluded_volume	58097 Å³
envelope_volume	105030 Å³
shell_volume	30437 Å³
envelope_diameter	101.9 Å
shell_rg	35.81 Å
envelope_rg	28.82 Å
shape_rg	29.00 Å
total_rg	29.49 Å
total_atoms	4548
n_residues	580
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	98.9 Å
rg_real	29.50 Å
rg_real_error	0.72 Å
i0_real	1.3190e+08
i0_real_error	2.3350e+06
rg_reciprocal	29.50 Å
i0_reciprocal	131900000.0000
total_estimate	0.8907
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	29.3 Å
skewness	0.266
kurtosis	-0.619
angular_range	— – 0.2700 Å⁻¹
current_alpha	0.0000
highest_alpha	42010000.0000
n_real_points	55
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.878; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.950; Smooth: 0.990

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Fibroblast growth factor receptor 1
formula_weight	35264.5 kDa
ec_number	2.7.10.1
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	5080

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	(E)-4-methyl-17-(1-methyl-1H-pyrazol-4-yl)-7,10-dioxa-4-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridinacyclodecaphan-3-one
formula_weight	419.4 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	2

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	532

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6. Citations (1)

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length_a	211.760 Å
length_b	49.790 Å
length_c	66.587 Å
angle_alpha	90.00 °
angle_beta	107.67 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 1 2 1
int_tables_number	5
crystal_system	—

resolution	1.660 Å
resolution_low	34.690 Å
r_factor	0.1886
r_work	0.1872
r_free	0.2161

fit	/app/data/saxs_computation/u7/9u7g/9u7g.fit
pddf	/app/data/pr_computation/u7/9u7g/9u7g.pr.out
profile	/app/data/saxs_computation/u7/9u7g/9u7g.dat

FGFR1 kinase domain with a macrocyclic compound 8g

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction