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21tv

Cryo-EM structure of the TNF-alpha-Ozoralizumab (OZR)-HSA complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tumor necrosis factor

Homo sapiens

UniProt P01375

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Ozoralizumab (OZR) × 1 Serum albumin × 1 （P02768） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7asy 7at7 7atb 7qlf

4 assemblies

Homodimer
5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8 5mu8

24 assemblies; showing the first 12

Homotetramer
2az5

1 assemblies

Other homooligomers
1a8m 1tnf 2e7a 2tun 2tun 2tun 2zjc 2zpx 4tsv 5m2j 5tsw 5tsw

36 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
21tv 21tw 3alq 3alq 3it8 3it8 3l9j 3wd5 4g3y 4g3y 4twt 4twt

34 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNFA_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 2–158； UniProt 77–233 Author chain C； PDBConstruct 2–158； UniProt 77–233 Author chain D； PDBConstruct 2–158； UniProt 77–233

Serum albumin

OrganismNot specified

UniProt P02768

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Ozoralizumab (OZR) × 1 Tumor necrosis factor × 3 （P01375） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ao6 1ao6 1bj5 1bke 1bm0 1bm0 1e78 1e78 1e7a 1e7a 1e7b 1e7b

230 assemblies; showing the first 12

Homodimer
3jqz 4g03 4g04

3 assemblies

Homotetramer

None

Other homooligomers
5z0b 9v61

2 assemblies

Heteromeric or nucleic-acid complex
1tf0 21tv 2vdb 4hgk 4hgk 4hgm 4k71 4k71 4k71 4n0f 4n0f 4n0f

37 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ALBU_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain E； PDBConstruct 1–585； UniProt 25–609

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id21tv
Deposition date deposition_date2025-12-26
Structure title titleCryo-EM structure of the TNF-alpha-Ozoralizumab (OZR)-HSA complex
Keywords keywordsNANOBODY, VHH, TNF-alpha, HSA, Ozoralizumab, OZR, CYTOKINE; CYTOKINE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

21tv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

21tv__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

21tv__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）46.68 Å
Rg (electron density)47.49 Å
Total Rg47.43 Å
Atom count6549
Residues1326
Excluded volume105700 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 21tv__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)