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2c35

Subunits Rpb4 and Rpb7 of human RNA polymerase II

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE

HOMO SAPIENS

UniProt O15514

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE × 1 （P62487） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE × 1 （P62487） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE × 1 （P62487） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE × 1 （P62487） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2c35 2c35 2c35 2c35 5iy6 5iy7 5iy8 5iy9 5iya 5iyb 5iyc 5iyd

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RPB4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 11–152； UniProt 1–142 Author chain C； PDBConstruct 11–152； UniProt 1–142 Author chain E； PDBConstruct 11–152； UniProt 1–142 Author chain G； PDBConstruct 11–152； UniProt 1–142

DNA-DIRECTED RNA POLYMERASE II 19 KDA POLYPEPTIDE

HOMO SAPIENS

UniProt P62487

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE × 1 （O15514） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE × 1 （O15514） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE × 1 （O15514） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE × 1 （O15514） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2c35 2c35 2c35 2c35 5iy6 5iy7 5iy8 5iy9 5iya 5iyb 5iyc 5iyd

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RPB7_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–172； UniProt 1–172 Author chain D； PDBConstruct 1–172； UniProt 1–172 Author chain F； PDBConstruct 1–172； UniProt 1–172 Author chain H； PDBConstruct 1–172； UniProt 1–172

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2c35
Deposition date deposition_date2005-10-04
Structure title titleSubunits Rpb4 and Rpb7 of human RNA polymerase II
Keywords keywordsTRANSCRIPTION, RNA POLYMERASE II, POLYMERASE, NUCLEOTIDYLTRANSFERASE, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2c35__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2c35__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2c35__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.16 Å
Rg (electron density)21.32 Å
Total Rg22.12 Å
Atom count2315
Residues297
Excluded volume41476 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2c35__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2c35__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2c35__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 2c35__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd2c35a1
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.8 — HRDC-like
Family Family familya.60.8.2 — RNA polymerase II subunit RBP4 (RpoF)
Domain ID domain_idd2c35b1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
Family Family familyb.40.4.5 — Cold shock DNA-binding domain-like
Domain ID domain_idd2c35b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.230 — Dodecin subunit-like
Superfamily Superfamily superfamilyd.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family familyd.230.1.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Domain ID domain_idd2c35c_
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.8 — HRDC-like
Family Family familya.60.8.2 — RNA polymerase II subunit RBP4 (RpoF)
Domain ID domain_idd2c35d1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
Family Family familyb.40.4.5 — Cold shock DNA-binding domain-like
Domain ID domain_idd2c35d2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.230 — Dodecin subunit-like
Superfamily Superfamily superfamilyd.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family familyd.230.1.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Domain ID domain_idd2c35e_
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.8 — HRDC-like
Family Family familya.60.8.2 — RNA polymerase II subunit RBP4 (RpoF)
Domain ID domain_idd2c35f1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
Family Family familyb.40.4.5 — Cold shock DNA-binding domain-like
Domain ID domain_idd2c35f2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.230 — Dodecin subunit-like
Superfamily Superfamily superfamilyd.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family familyd.230.1.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Domain ID domain_idd2c35g_
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.8 — HRDC-like
Family Family familya.60.8.2 — RNA polymerase II subunit RBP4 (RpoF)
Domain ID domain_idd2c35h1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
Family Family familyb.40.4.5 — Cold shock DNA-binding domain-like
Domain ID domain_idd2c35h2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.230 — Dodecin subunit-like
Superfamily Superfamily superfamilyd.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family familyd.230.1.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)

CATH v4.4 (12 domains)

Domain ID domain_id2c35A00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily40 — RNA Polymerase II, Rpb4 subunit
Domain ID domain_id2c35B01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily120 — RNA polymerase Rpb7-like, N-terminal domain
Domain ID domain_id2c35B02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
Domain ID domain_id2c35C00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily40 — RNA Polymerase II, Rpb4 subunit
Domain ID domain_id2c35D01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily120 — RNA polymerase Rpb7-like, N-terminal domain
Domain ID domain_id2c35D02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
Domain ID domain_id2c35E00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily40 — RNA Polymerase II, Rpb4 subunit
Domain ID domain_id2c35F01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily120 — RNA polymerase Rpb7-like, N-terminal domain
Domain ID domain_id2c35F02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
Domain ID domain_id2c35G00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily40 — RNA Polymerase II, Rpb4 subunit
Domain ID domain_id2c35H01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily120 — RNA polymerase Rpb7-like, N-terminal domain
Domain ID domain_id2c35H02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
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7. Citations (1)