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2cax

STRUCTURAL BASIS FOR COOPERATIVE BINDING OF RIBBON-HELIX-HELIX REPRESSOR OMEGA TO MUTATED DIRECT DNA HEPTAD REPEATS

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ORF OMEGA

STREPTOCOCCUS PYOGENES

UniProt Q57468

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Homooligomer Protein 4 DNA 4 ;5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*AP *TP*CP*AP*CP*AP*AP*G)-3' ; × 1 ;5'-D(*TP*TP*GP*TP*GP*AP*TP*TP*TP*GP *TP*GP*AP*TP*TP*CP*G)-3' ; × 1 ;5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*GP *TP*CP*AP*CP*AP*AP*GP*C)-3' ; × 1 ;5'-D(*CP*TP*TP*GP*TP*GP*AP*CP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3' ; × 1 water × 7 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1irq

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2bnw 2bnz 2cax

3 assemblies

View Construct and Data Evidence
UniProt name Q57468_STRPY
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–53； UniProt 20–71 Author chain B； PDBConstruct 2–53； UniProt 20–71 Author chain C； PDBConstruct 2–53； UniProt 20–71 Author chain D； PDBConstruct 2–53； UniProt 20–71

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2cax
Deposition date deposition_date2005-12-23
Structure title titleSTRUCTURAL BASIS FOR COOPERATIVE BINDING OF RIBBON-HELIX-HELIX REPRESSOR OMEGA TO MUTATED DIRECT DNA HEPTAD REPEATS
Keywords keywords;TRANSCRIPTIONAL REPRESSOR, INC18 FAMILY OF PLASMIDS, RHH, METJ/ARC SUPERFAMILY, COOPERATIVE DNA BINDING, DNA HEPTAD 5'- A/T ATCAC A/T -3', PLASMID MAINTENANCE, DNA- BINDING, REGULATORY PROTEIN ;; TRANSCRIPTIONAL REPRESSOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2cax__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2cax__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2cax__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.50 Å
Rg (electron density)31.13 Å
Total Rg31.41 Å
Atom count3083
Residues273
Excluded volume50624 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2cax__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd2caxa2
Class classa — All alpha proteins
Fold Fold folda.43 — Ribbon-helix-helix
Superfamily Superfamily superfamilya.43.1 — Ribbon-helix-helix
Family Family familya.43.1.4 — Omega transcriptional repressor
Domain ID domain_idd2caxa3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2caxb_
Class classa — All alpha proteins
Fold Fold folda.43 — Ribbon-helix-helix
Superfamily Superfamily superfamilya.43.1 — Ribbon-helix-helix
Family Family familya.43.1.4 — Omega transcriptional repressor
Domain ID domain_idd2caxc2
Class classa — All alpha proteins
Fold Fold folda.43 — Ribbon-helix-helix
Superfamily Superfamily superfamilya.43.1 — Ribbon-helix-helix
Family Family familya.43.1.4 — Omega transcriptional repressor
Domain ID domain_idd2caxc3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2caxd_
Class classa — All alpha proteins
Fold Fold folda.43 — Ribbon-helix-helix
Superfamily Superfamily superfamilya.43.1 — Ribbon-helix-helix
Family Family familya.43.1.4 — Omega transcriptional repressor

CATH v4.4 (4 domains)

Domain ID domain_id2caxA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1220 — Arc Repressor Mutant
Homologous superfamily homologous superfamily10 — Met repressor-like
Domain ID domain_id2caxB00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1220 — Arc Repressor Mutant
Homologous superfamily homologous superfamily10 — Met repressor-like
Domain ID domain_id2caxC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1220 — Arc Repressor Mutant
Homologous superfamily homologous superfamily10 — Met repressor-like
Domain ID domain_id2caxD00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1220 — Arc Repressor Mutant
Homologous superfamily homologous superfamily10 — Met repressor-like
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7. Citations (1)