2hpc

Crystal structure of fragment D from Human Fibrinogen Complexed with Gly-Pro-Arg-Pro-amide.

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Fibrinogen alpha chain

物种未注明

UniProt P02671

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen beta chain × 1 (P02675) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen beta chain × 1 (P02675) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen beta chain × 1 (P02675) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen beta chain × 1 (P02675) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FIBA_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–87; UniProt 130–216 作者链 D; PDB构建体 1–87; UniProt 130–216 作者链 G; PDB构建体 1–87; UniProt 130–216 作者链 J; PDB构建体 1–87; UniProt 130–216

Fibrinogen beta chain

物种未注明

UniProt P02675

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen, gamma polypeptide × 1 (Q53Y18) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FIBB_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–328; UniProt 164–491 作者链 E; PDB构建体 1–328; UniProt 164–491 作者链 H; PDB构建体 1–328; UniProt 164–491 作者链 K; PDB构建体 1–328; UniProt 164–491

Fibrinogen, gamma polypeptide

物种未注明

UniProt Q53Y18

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen beta chain × 1 (P02675) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen beta chain × 1 (P02675) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen beta chain × 1 (P02675) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 2 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 Fibrinogen alpha chain × 1 (P02671) Fibrinogen beta chain × 1 (P02675) Gly-Pro-Arg-Pro-amide peptide ligand × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CALCIUM ION × 3 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q53Y18_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–323; UniProt 115–437 作者链 F; PDB构建体 1–323; UniProt 115–437 作者链 I; PDB构建体 1–323; UniProt 115–437 作者链 L; PDB构建体 1–323; UniProt 115–437

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2hpc
沉积日期 deposition_date2006-07-17
结构标题 titleCrystal structure of fragment D from Human Fibrinogen Complexed with Gly-Pro-Arg-Pro-amide.
关键词 keywordsfibrin knob-hole interaction, BLOOD CLOTTING; BLOOD CLOTTING
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2hpc__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2hpc__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2hpc__assembly_3__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)34.01 Å
Rg(电子密度)34.83 Å
总 Rg35.03 Å
原子数5592
残基数694
排除体积98427 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2hpc__assembly_1__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2hpc__assembly_2__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2hpc__assembly_3__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 2hpc__assembly_4__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (6)

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6. 折叠分类 (SCOP + CATH) 28 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd2hpca1
类 Class classh — Coiled coil proteins
折叠类型 Fold foldh.1 — Parallel coiled-coil
超家族 Superfamily superfamilyh.1.8 — Fibrinogen coiled-coil and central regions
家族 Family familyh.1.8.1 — Fibrinogen coiled-coil and central regions
结构域编号 domain_idd2hpcd1
类 Class classh — Coiled coil proteins
折叠类型 Fold foldh.1 — Parallel coiled-coil
超家族 Superfamily superfamilyh.1.8 — Fibrinogen coiled-coil and central regions
家族 Family familyh.1.8.1 — Fibrinogen coiled-coil and central regions
结构域编号 domain_idd2hpcg1
类 Class classh — Coiled coil proteins
折叠类型 Fold foldh.1 — Parallel coiled-coil
超家族 Superfamily superfamilyh.1.8 — Fibrinogen coiled-coil and central regions
家族 Family familyh.1.8.1 — Fibrinogen coiled-coil and central regions
结构域编号 domain_idd2hpcj1
类 Class classh — Coiled coil proteins
折叠类型 Fold foldh.1 — Parallel coiled-coil
超家族 Superfamily superfamilyh.1.8 — Fibrinogen coiled-coil and central regions
家族 Family familyh.1.8.1 — Fibrinogen coiled-coil and central regions

CATH v4.4 (24 domains)

结构域编号 domain_id2hpcA00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcB01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcB02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcB03
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcC01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcC02
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcE01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcE02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcE03
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcF01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcF02
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcG00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcH01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcH02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcH03
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcI01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcI02
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcJ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcK01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily50 —
结构域编号 domain_id2hpcK02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcK03
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
结构域编号 domain_id2hpcL01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Gamma Fibrinogen, chain A, domain 1
结构域编号 domain_id2hpcL02
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
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