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2hwn

Crystal Structure of RII alpha Dimerization/Docking domain of PKA bound to the D-AKAP2 peptide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

cAMP-dependent protein kinase type II-alpha regulatory subunit

Rattus norvegicus

UniProt P12368

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 A Kinase binding peptide × 1 GLYCEROL × 1 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 A Kinase binding peptide × 1 water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 6 A Kinase binding peptide × 2 GLYCEROL × 1 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2izy

1 assemblies

Heteromeric or nucleic-acid complex
2drn 2h9r 2hwn 2hwn 2hwn 3tmh

6 assemblies

View Construct and Data Evidence
UniProt name KAP2_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–45； UniProt 0–44 Author chain B； PDBConstruct 1–45； UniProt 0–44 Author chain C； PDBConstruct 1–45； UniProt 0–44 Author chain D； PDBConstruct 1–45； UniProt 0–44

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2hwn
Deposition date deposition_date2006-08-01
Structure title titleCrystal Structure of RII alpha Dimerization/Docking domain of PKA bound to the D-AKAP2 peptide
Keywords keywordsPKA, AKAP, Dimerization/Docking, D/D, Regulatory Subunit, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2hwn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2hwn__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2hwn__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.87 Å
Rg (electron density)13.26 Å
Total Rg14.63 Å
Atom count821
Residues103
Excluded volume14766 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2hwn__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2hwn__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2hwn__assembly_3__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 7 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd2hwna_
Class classa — All alpha proteins
Fold Fold folda.31 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Superfamily Superfamily superfamilya.31.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Family Family familya.31.1.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Domain ID domain_idd2hwnb_
Class classa — All alpha proteins
Fold Fold folda.31 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Superfamily Superfamily superfamilya.31.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Family Family familya.31.1.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Domain ID domain_idd2hwnc_
Class classa — All alpha proteins
Fold Fold folda.31 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Superfamily Superfamily superfamilya.31.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Family Family familya.31.1.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Domain ID domain_idd2hwnd_
Class classa — All alpha proteins
Fold Fold folda.31 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Superfamily Superfamily superfamilya.31.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit
Family Family familya.31.1.1 — Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit

CATH v4.4 (3 domains)

Domain ID domain_id2hwnB00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology890 — cAMP-dependent Protein Kinase, Chain A
Homologous superfamily homologous superfamily10 — cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Domain ID domain_id2hwnC00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology890 — cAMP-dependent Protein Kinase, Chain A
Homologous superfamily homologous superfamily10 — cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Domain ID domain_id2hwnD00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology890 — cAMP-dependent Protein Kinase, Chain A
Homologous superfamily homologous superfamily10 — cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
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7. Citations (1)