2k03
Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 2k03 |
| 沉积日期 deposition_date | 2008-01-24 |
| 结构标题 title | Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21 |
| 关键词 keywords | ;stromal cell derived factor-1, SDF1-alpha, CXCL12, CXCR4, chemokine, sulfotyrosine, locked dimer, Alternative splicing, Chemotaxis, Cytokine, Growth factor, Secreted, G-protein coupled receptor, Glycoprotein, Host-virus interaction, Membrane, Receptor, Sulfation, Transducer, Transmembrane ;; CYTOKINE |
| 实验方法 method | SOLUTION NMR |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 17.85 Å |
| 回转半径 Rg (电子) rg_electron | 17.35 Å |
| 零角强度 I(0) i0 | 3728350000.00 |
| 分子量 molecular_weight | 496630.0 kDa |
| 排除体积 excluded_volume | 612610 ų |
| 包络体积 envelope_volume | 81850 ų |
| 水化壳体积 shell_volume | 29081 ų |
| 包络直径 envelope_diameter | 89.3 Å |
| 壳层 Rg shell_rg | 31.07 Å |
| 包络 Rg envelope_rg | 23.84 Å |
| 形状 Rg shape_rg | 17.35 Å |
| 总 Rg total_rg | 17.56 Å |
| 总原子数 total_atoms | 68340 |
| 残基数 n_residues | 4200 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 70.4 Å |
| Rg (实空间) rg_real | 17.79 Å |
| Rg 误差 (实空间) rg_real_error | 0.69 Å |
| I(0) (实空间) i0_real | 3.7280e+09 |
| I(0) 误差 (实空间) i0_real_error | 4.6640e+07 |
| Rg (倒空间) rg_reciprocal | 17.79 Å |
| I(0) (倒空间) i0_reciprocal | 3728000000.0000 |
| 解质量估计 total_estimate | 0.5459 |
| 解质量评级 solution_quality | REASONABLE a REASONABLE solution |
| P(r) 峰数 n_peaks | 4 |
| 主峰位置 r_peak_primary | 23.8 Å |
| 偏度 Skewness skewness | 0.343 |
| 峰度 Kurtosis kurtosis | 0.155 |
| 角度范围 angular_range | — – 0.4450 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 4292000.0000 |
| 实空间数据点数 n_real_points | 75 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.382; Stabil: 0.998; Sysdev: 0.346; Positv: 1.000; Valcen: 0.913; Smooth: 0.000 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (2)
6. 折叠分类 (SCOP + CATH) 4 domains
SCOP 2.08 (2 domains)
| 结构域编号 domain_id | d2k03a_ |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.9 — IL8-like |
| 超家族 Superfamily superfamily | d.9.1 — Interleukin 8-like chemokines |
| 家族 Family family | d.9.1.1 — Interleukin 8-like chemokines |
| 结构域编号 domain_id | d2k03c_ |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.9 — IL8-like |
| 超家族 Superfamily superfamily | d.9.1 — Interleukin 8-like chemokines |
| 家族 Family family | d.9.1.1 — Interleukin 8-like chemokines |
CATH v4.4 (2 domains)
| 结构域编号 domain_id | 2k03A00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
| 同源超家族 H-superfamily homologous superfamily | 40 — |
| 结构域编号 domain_id | 2k03C00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
| 同源超家族 H-superfamily homologous superfamily | 40 — |