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2k05

Structure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7, 12 and 21

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Stromal cell-derived factor 1

Homo sapiens

UniProt P48061

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 C-X-C chemokine receptor type 4 × 2 （P61073） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1sdf 1vmc 2kec 2ked 2kee 2kol 2sdf 6shr

8 assemblies

Homodimer
1a15 1qg7 2j7z 2k01 4uai

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2k03 2k04 2k05 2n55 2nwg 4lmq 4lmq 7sk3 7sk4 7sk5 7sk6 7sk7

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SDF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–70； UniProt 22–89 Author chain C； PDBConstruct 3–70； UniProt 22–89

C-X-C chemokine receptor type 4

Homo sapiens

UniProt P61073

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Stromal cell-derived factor 1 × 2 （P48061） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer
8yu7 9mdu

2 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
22xc 2k03 2k04 2k05 2n55 3odu 3oe0 3oe6 3oe8 3oe8 3oe8 3oe9

33 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CXCR4_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 3–40； UniProt 1–38 Author chain D； PDBConstruct 3–40； UniProt 1–38

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2k05
Deposition date deposition_date2008-01-24
Structure title titleStructure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7, 12 and 21
Keywords keywords;stromal cell derived factor-1, SDF1-alpha, CXCL12, CXCR4, chemokine, sulfotyrosine, locked dimer, Alternative splicing, Chemotaxis, Cytokine, Growth factor, Secreted, G-protein coupled receptor, Glycoprotein, Host-virus interaction, Membrane, Receptor, Sulfation, Transducer, Transmembrane ;; CYTOKINE
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2k05__assembly_1__model_20

Assembly 1 · Model 20 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2k05__assembly_1__model_20 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2k05__assembly_1__model_20 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.42 Å
Rg (electron density)17.17 Å
Total Rg18.21 Å
Atom count3429
Residues206
Excluded volume30841 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2k05__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2k05__assembly_1__model_2 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2k05__assembly_1__model_3 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2k05__assembly_1__model_4 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2k05__assembly_1__model_5 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2k05__assembly_1__model_6 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2k05__assembly_1__model_7 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2k05__assembly_1__model_8 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2k05__assembly_1__model_9 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2k05__assembly_1__model_10 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2k05__assembly_1__model_11 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2k05__assembly_1__model_12 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2k05__assembly_1__model_13 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2k05__assembly_1__model_14 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2k05__assembly_1__model_15 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2k05__assembly_1__model_16 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2k05__assembly_1__model_17 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2k05__assembly_1__model_18 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2k05__assembly_1__model_19 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2k05__assembly_1__model_20 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2k05a_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.9 — IL8-like
Superfamily Superfamily superfamilyd.9.1 — Interleukin 8-like chemokines
Family Family familyd.9.1.1 — Interleukin 8-like chemokines
Domain ID domain_idd2k05c_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.9 — IL8-like
Superfamily Superfamily superfamilyd.9.1 — Interleukin 8-like chemokines
Family Family familyd.9.1.1 — Interleukin 8-like chemokines

CATH v4.4 (2 domains)

Domain ID domain_id2k05A00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2k05C00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily40 —
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7. Citations (1)