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2l5x

Solution structure of IL1A-S100A13 complex

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Interleukin-1 alpha

Homo sapiens

UniProt P01583

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Protein S100-A13 × 2 （Q99584） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2ila 2kki

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2l5x 5uc6

2 assemblies

View Construct and Data Evidence
UniProt name IL1A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–151； UniProt 121–271 Author chain D； PDBConstruct 1–151； UniProt 121–271

Protein S100-A13

Homo sapiens

UniProt Q99584

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Interleukin-1 alpha × 2 （P01583） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1yur 1yus 1yut 1yuu 2egd 2h2k 2kot

7 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2k8m 2ki4 2ki6 2l5x 2le9

5 assemblies

View Construct and Data Evidence
UniProt name S10AD_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–98； UniProt 1–98 Author chain C； PDBConstruct 1–98； UniProt 1–98

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2l5x
Deposition date deposition_date2010-11-09
Structure title titleSolution structure of IL1A-S100A13 complex
Keywords keywords;Protein-protein complex, key component in non-classical pathway of IL-1a, Interleukin-1alpha, S100A13, CYTOKINE-TRANSPORT PROTEIN complex ;; CYTOKINE/TRANSPORT PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2l5x__assembly_1__model_19

Assembly 1 · Model 19 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2l5x__assembly_1__model_19 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2l5x__assembly_1__model_19 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）30.40 Å
Rg (electron density)30.31 Å
Total Rg30.76 Å
Atom count8128
Residues498
Excluded volume72588 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2l5x__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2l5x__assembly_1__model_2 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2l5x__assembly_1__model_3 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2l5x__assembly_1__model_4 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2l5x__assembly_1__model_5 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2l5x__assembly_1__model_6 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2l5x__assembly_1__model_7 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2l5x__assembly_1__model_8 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2l5x__assembly_1__model_9 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2l5x__assembly_1__model_10 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2l5x__assembly_1__model_11 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2l5x__assembly_1__model_12 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2l5x__assembly_1__model_13 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2l5x__assembly_1__model_14 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2l5x__assembly_1__model_15 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2l5x__assembly_1__model_16 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2l5x__assembly_1__model_17 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2l5x__assembly_1__model_18 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2l5x__assembly_1__model_19 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2l5x__assembly_1__model_20 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd2l5xa_
Class classb — All beta proteins
Fold Fold foldb.42 — beta-Trefoil
Superfamily Superfamily superfamilyb.42.1 — Cytokine
Family Family familyb.42.1.2 — Interleukin-1 (IL-1)
Domain ID domain_idd2l5xb_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.0 — automated matches
Domain ID domain_idd2l5xc_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.0 — automated matches
Domain ID domain_idd2l5xd_
Class classb — All beta proteins
Fold Fold foldb.42 — beta-Trefoil
Superfamily Superfamily superfamilyb.42.1 — Cytokine
Family Family familyb.42.1.2 — Interleukin-1 (IL-1)

CATH v4.4 (4 domains)

Domain ID domain_id2l5xA00
Class class2 — Mainly Beta
Architecture architecture80 — Trefoil
Topology topology10 — Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homologous superfamily homologous superfamily50 —
Domain ID domain_id2l5xB00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2l5xC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2l5xD00
Class class2 — Mainly Beta
Architecture architecture80 — Trefoil
Topology topology10 — Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homologous superfamily homologous superfamily50 —
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7. Citations (1)